- Gestational Diabetes: 30% increase since 2016 (July 2023)
- Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients
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- VitaminDWiki - Pregnancy category contains
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Gestational Diabetes: 30% increase since 2016 (July 2023)
Gestational diabetes impacts nearly 75,000 pregnant individuals and their unborn babies each year in the United States, and according to the Centers for Disease Control cases have risen 30% since 2016.
Which is probably similar to the increase of Diabetes in the same time period
Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients
Endocrine . 2023 Apr;80(1):191-200. doi: 10.1007/s12020-022-03272-9
Shweta Varshney # 1, Ramu Adela # 1 2, Garima Kachhawa 3, Reema Dada 4, Vidushi Kulshreshtha 3, Rajesh Kumari 3, Ramesh Agarwal 5, Rajesh Khadgawat 6Introduction: Gestational diabetes (GDM) and pre-eclampsia (PE) represents the unrecognized risk factors for reduced bone content in neonates. The present study is planned to explore the components of vitamin D metabolism and calcium transport in placenta of GDM and PE cases and its effect on the neonatal bone mass determination using bone densitometry system.
Methods: We have collected serum and placenta tissues from GDM (n = 20), PE (n = 20), and healthy pregnancies (n = 20). In the present study, we found mRNA expression of oxidative stress markers, vitamin D metabolic components and calcium channels, calcium channel binding proteins, plasma membrane calcium ATPase, ATP synthase and Ca2+ release genes; Ryanodine receptors genes were assessed by quantitative real-time PCR (qRT-PCR) in placental tissue of GDM, PE, and healthy pregnancies.
Results: We observed high level of oxidative stress in both GDM and PE placenta compared to normal pregnancies.
- CYP2R1 and VDR mRNA expression was significantly downregulated and
- upregulation of CYP27B1 and CYP24A1 in GDM and PE compared with healthy cases.
Similarly, calcium transporters were downregulated in GDM and PE placental tissues. In addition, CYP24A1, VDR, CaBP28K, TRPV5 and PMCA3 mRNA expression were correlated with BMC of neonates.
Discussion: Oxidative stress is probably relevant to disrupted vitamin D homeostasis and calcium transport in the placenta of GDM and PE cases. The altered regulatory mechanism of CYP24A1 and VDR could indicates more pronounced serum 25(OH)D reduction. Additionally, reduced BMC in the neonates of these cases might be as consequences of modified CYP24A1, VDR, CaBP28K, TRPV5 and PMCA3 mRNA expression.
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VitaminDWiki – Genetics category contains
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- Nanoemulsion Vitamin D may be a substantially better form
- 1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
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- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
- Commercially available 2019
- However, test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family- especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016- easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
4) Back Pain- probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of VitaminDWiki took action with clues #3&4
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791 items - Pregnancy needs at least 40 ng of vitamin D, achieved by at least 4,000 IU – Hollis Aug 2017
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VitaminDWiki -
24 studies in both categories Pregnancy and VDR This list is automatically updated
- Poor placental Vitamin D genes associated with gestational diabetes and preeclampsia - April 2023
- Hypertension during pregnancy: low Vitamin D, poor Vit. D genes – June 2022
- Preeclampsia reduced by Vitamin D - many studies
- After lactation Vitamin D levels are low, increased risk of Breast Cancer, vitamin D should decrease risk – Aug 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Higher risk of Recurrent Pregnancy Loss if poor Vitamin D Receptor – Feb 2021
- Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020
- Preterm birth associated with many genes, including the Vitamin D Receptor again – Jan 2020
- Preterm birth 8X more likely if poor Vitamin D Receptor – Dec 2019
- Preterm birth 9 X more likely if fetus had a poor Vitamin D Receptor and previous miscarriage – Aug 2017
- Recurrent miscarriage occurs 2.2 more often if poor Vitamin D Receptor – Aug 2019
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Preeclampsia 2X more likely if poor Vitamin D Receptor – April 2019
- Preterm births 12 X more likely if poor Vitamin D Receptor (white infants in Italy) – meta-analysis Aug 2018
- UV at time of conception associated with Vitamin D Receptor activation 65 years later – Sept 2017
- A good Vitamin D Receptor (or perhaps more vitamin D) protects against lead during pregnancy
- Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Frequent miscarriage associated with both lower vitamin D and poor Vitamin D receptor – Sept 2017
- Vitamin D genes and pregnancy – 7th study - Sept 2017
- Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc
- Recurrent miscarriage associated with half as much vitamin D getting to fetus – Sept 2016
- Progesterone activates vitamin D receptor - many studies
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5652 visits to this page Poor placental Vitamin D genes associated with gestational diabetes and preeclampsia - April 20233406 visitors, last modified 20 Jul, 2023, This page is in the following categories (# of items in each category)Attached files
ID Name Comment Uploaded Size Downloads 19414 other genes.jpg admin 02 Apr, 2023 13:20 118.21 Kb 121 19413 CYP24A1, VDR.jpg admin 02 Apr, 2023 13:20 40.24 Kb 126 19412 CYP2R1, CYP27B1.jpg admin 02 Apr, 2023 13:19 41.78 Kb 125 19411 Neonate.jpg admin 02 Apr, 2023 13:19 96.11 Kb 128 19410 preg and gene table.jpg admin 02 Apr, 2023 13:19 96.36 Kb 141 19409 Genes Vitamin D, GF, pre-ec_CompressPdf.pdf PDF 2023 admin 02 Apr, 2023 13:19 334.02 Kb 104 - All items in category Infant/Child
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