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Gestational Diabetes and Vitamin D - many studies

Gestational Diabetes: 30% increase in US since 2016 (reported July 2023)

Gestational diabetes impacts nearly 75,000 pregnant individuals and their unborn babies each year in the United States, and according to the Centers for Disease Control cases have risen 30% since 2016.
Which is probably similar to the increase of Diabetes in the same time period

Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients - April 2023

Endocrine . 2023 Apr;80(1):191-200. doi: 10.1007/s12020-022-03272-9
Shweta Varshney # 1, Ramu Adela # 1 2, Garima Kachhawa 3, Reema Dada 4, Vidushi Kulshreshtha 3, Rajesh Kumari 3, Ramesh Agarwal 5, Rajesh Khadgawat 6





Introduction: Gestational diabetes (GDM) and pre-eclampsia (PE) represents the unrecognized risk factors for reduced bone content in neonates. The present study is planned to explore the components of vitamin D metabolism and calcium transport in placenta of GDM and PE cases and its effect on the neonatal bone mass determination using bone densitometry system.

Methods: We have collected serum and placenta tissues from GDM (n = 20), PE (n = 20), and healthy pregnancies (n = 20). In the present study, we found mRNA expression of oxidative stress markers, vitamin D metabolic components and calcium channels, calcium channel binding proteins, plasma membrane calcium ATPase, ATP synthase and Ca2+ release genes; Ryanodine receptors genes were assessed by quantitative real-time PCR (qRT-PCR) in placental tissue of GDM, PE, and healthy pregnancies.

Results: We observed high level of oxidative stress in both GDM and PE placenta compared to normal pregnancies.

  • CYP2R1 and VDR mRNA expression was significantly downregulated and
  • upregulation of CYP27B1 and CYP24A1 in GDM and PE compared with healthy cases.

Similarly, calcium transporters were downregulated in GDM and PE placental tissues. In addition, CYP24A1, VDR, CaBP28K, TRPV5 and PMCA3 mRNA expression were correlated with BMC of neonates.

Discussion: Oxidative stress is probably relevant to disrupted vitamin D homeostasis and calcium transport in the placenta of GDM and PE cases. The altered regulatory mechanism of CYP24A1 and VDR could indicates more pronounced serum 25(OH)D reduction. Additionally, reduced BMC in the neonates of these cases might be as consequences of modified CYP24A1, VDR, CaBP28K, TRPV5 and PMCA3 mRNA expression.
Other Genes
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>30 ng of Vitamin D in 2nd tri. associated with 39% less risk of Gestational Diabetes - April 2024

Maternal vitamin D status and risk of gestational diabetes mellitus in twin pregnancies: a longitudinal twin pregnancies birth cohort study
Nutr J. 2024 Apr 10;23(1):41. doi: 10.1186/s12937-024-00944-2.
Da-Yan Li # 1 2 3, Lan Wang # 3 4, Li Li 3 4, Shuwei Zhou 3 4, Jiangyun Tan 3 4, Chunyan Tang 3 4, Qianqian Liao 3 4, Ting Liu 3 4, Li Wen 5 6, Hong-Bo Qi 7 8

Background: Gestational diabetes mellitus (GDM) is a common complication of pregnancy, with significant short-term and long-term implications for both mothers and their offspring. Previous studies have indicated the potential benefits of vitamin D in reducing the risk of GDM, yet little is known about this association in twin pregnancies. This study aimed to investigate maternal vitamin D status in the second trimester and examine its association with the risk of GDM in twin pregnancies.

Methods: We conducted a prospective cohort study based on data from the Chongqing Longitudinal Twin Study (LoTiS). Peripheral blood serum was collected from the mothers in the second trimester to measure 25(OH)D concentrations. GDM was diagnosed at 23-26 weeks of gestation using a 75-g 2-h oral glucose tolerance test. We used multivariable logistic regression analyses to examine the correlations between vitamin D status and the risk of GDM.

Results: Of the total participants, 93 (29.9%) women were diagnosed with GDM. The mean serum 25(OH)D concentration in the second trimester was 31.1 ± 11.2 ng/mL, and the rate of vitamin D insufficiency and deficiency were 23.5% and 18.7%, respectively. Compared to women with a 25(OH)D concentration < 30 ng/mL, those with a 25(OH)D concentration ≥ 30 ng/mL had a significantly lower risk of GDM (RR 0.61; 95% CI: 0.43, 0.86), especially those who were overweight before pregnancy (RR 0.32; 95% CI: 0.16, 0.64). The restricted cubic splines model showed an inverted J-shaped relationship between vitamin D concentrations and GDM risk.

Conclusions: The risk of GDM was significantly reduced in twin pregnant women with vitamin D concentrations ≥ 30 ng/mL in the second trimester.

Trial registration: ChiCTR-OOC-16,008,203. Retrospectively registered on 1 April 2016.
Some of the References

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39+ VitaminDWiki pages have GESTATIONAL DIABETES in the title

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Items found: 40
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Gestational Diabetes and Vitamin D - many studies 10 Apr, 2024
Gestational Diabetes and Vitamin D - many studies 10 Apr, 2024
Gestational Diabetes best fought by Vitamin D plus probiotics – RCT review Dec 2023 11 Jan, 2024
Gestational Diabetes reduced with 50,000 IU of vitamin D every 3 weeks and daily Calcium – RCT June 2014 17 Jul, 2023
50,000 IU of Vitamin D every 2 weeks reduced gestational diabetes – RCT Feb 2015 12 Jul, 2023
Gestational Diabetes Mellitus 10X more-likely if low vitamin D in first trimester – July 2022 07 Aug, 2022
Gestational Diabetes 2.1 X more likely if less than 30 ng of Vitamin D - July 2022 14 Jul, 2022
Gestational diabetes risk reduced 1.5X by Vitamin D – meta-analysis March 2021 14 Jul, 2022
Vitamin D reduces preeclampsia, gestational diabetes and hypertension - 38th meta-analysis Dec 2021 31 May, 2022
Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021 14 Dec, 2021
300,000 IU injection loading dose of vitamin D3 stopped gestational diabetes in RCT – Oct 2011 25 Jul, 2020
Vitamin D cuts pregnancy risks in half – low birth weight, preeclampsia, gestational diabetes – Cochrane July 2019 12 Sep, 2019
Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019 24 Jun, 2019
Vitamin D food fortification during pregnancy reduced gestational diabetes in daughters by 13 percent – Nov 2018 14 Jun, 2019
Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019 18 May, 2019
Gestational diabetes 60 percent more likely below 20 ng of vitamin D – meta-analysis Feb 2012 23 Mar, 2019
Vitamin D treats Gestational Diabetes, decreases hospitalization and newborn complications – meta-analysis March 2019 23 Mar, 2019
Gestational Diabetes 39 percent more likely if insufficient Vitamin D – Meta-analysis March 2018 17 Mar, 2018
Gestational Diabetes Mellitus 1.5X more likely if low vitamin D – meta-analysis Oct 2015 07 Feb, 2018
Gestational diabetes treated by Vitamin D plus Omega-3 – RCT Feb 2017 02 Jan, 2018
Gestational Diabetes increasing, especially in dark skinned women (low vitamin D) - 2007 30 Dec, 2017
Gestational Diabetes 1.9 X more likely if low vitamin D – review Dec 2017 15 Dec, 2017
Congenital Heart Disease is associated with gestational diabetes in first trimester (need Vitamin D and Omega-3 early) Dec 2017 15 Dec, 2017
Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017 10 Nov, 2017
Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015 09 Nov, 2017
Gestational diabetes 30 percent less likely if consumed more than 400 IU of vitamin D daily – Oct 2017 04 Oct, 2017
Low vitamin D plus gestational diabetes resulted in increased ICU use, SGA – Oct 2016 07 Jun, 2017
Gestational Diabetes 3.7 X more likely if smoke and have low vitamin D (no surprise) – Feb 2016 04 Jan, 2017
Gestational Diabetes reduce 3 times by 5,000 IU of Vitamin D – RCT Jan 2016 10 Dec, 2016
Gestational Diabetes treated with 50,000 IU every two weeks – RCT Sept 2016 03 Sep, 2016
Infant much healthier if Gestational Diabetic mother got 2 doses of vitamin D – RCT Nov 2014 09 Apr, 2016
Gestational Diabetes helped by Vitamin D and Calcium (also less C-section and LGA) – RCT Jan 2016 16 Jan, 2016
Gestational diabetes – Vitamin D and Calcium provided huge benefits – RCT March 2015 13 Jan, 2016
Gestational diabetes reduced by just two 50,000 IU doses of vitamin D – RCT Nov 2014 02 Oct, 2015
Increased Gestational Diabetes and poorer infant health associated with low vitamin D – June 2015 01 Jul, 2015
Gestational Diabetes in 10 percent of pregnancies, vitamin D probably helps – Jan 2014 14 Apr, 2015
Gestational Diabetes reduced 40 percent by 5,000 IU of vitamin D – RCT April 2014 02 Mar, 2015
Gestational Diabetes mostly treated with just 2 doses of 50,000 IU of vitamin D – RCT Dec 2013 26 Jun, 2014
Will 1600 IU vitamin D prevent gestational diabetes – no, not enough, July 2013 31 Aug, 2013
Gestational diabetes 2.2X more likely below 10 ng of vitamin D – June 2012 15 Nov, 2012

VitaminDWiki – Genetics category contains

334 articles in the Genetics category

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Vitamin D blood test misses a lot
in Visio for 2023

  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)   Commercially available 2019
    • However, test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
        especially if it is one of 51+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
    3) DNA and VDR tests - 120 to 200 dollars $100 to $250
    4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
       Genes are good, have enough Magnesium, etc.
    5) Back Pain
       probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
      • The founder of VitaminDWiki took action with clues #3&5

VitaminDWiki - Pregnancy category contains

895 items in Pregnancy category

 - see also

VitaminDWiki - 24 studies in both categories Pregnancy and VDR

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21077 Chongging.png admin 10 Apr, 2024 868.52 Kb 38
19414 other genes.jpg admin 02 Apr, 2023 118.21 Kb 241
19413 CYP24A1, VDR.jpg admin 02 Apr, 2023 40.24 Kb 244
19412 CYP2R1, CYP27B1.jpg admin 02 Apr, 2023 41.78 Kb 250
19411 Neonate.jpg admin 02 Apr, 2023 96.11 Kb 262
19410 preg and gene table.jpg admin 02 Apr, 2023 96.36 Kb 278
19409 Genes Vitamin D, GF, pre-ec_CompressPdf.pdf admin 02 Apr, 2023 334.02 Kb 206