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Multiple Vitamin D doses reduced COVID ICU by 2.5 X , Mech. Ventilation by 5.5 X – meta-analysis May 2024

Therapeutic effects of vitamin D supplementation on COVID-19 aggravation: a systematic review and meta-analysis of randomized controlled trials

Front. Pharmacol., 26 May 2024 Volume 15 - 2024 | https://doi.org/10.3389/fphar.2024.1367686
Yiyuan YangYiyuan YangWanli SunWanli SunFan YangFan YangGuoxia ZhangGuoxia ZhangXinye LiXinye LiShipeng Sun
Shipeng Sun*Yanwei Xing
Yanwei Xing* Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China

Background: The therapeutic effects of vitamin D supplementation on Coronavirus disease 2019 (COVID-19) aggravation remain controversial and inconclusive. To probe into this contentious issue, we performed the present meta-analysis of randomized controlled trials (RCTs).

Methods: Literature published up to June 2023 was retrieved from Cochrane Library, PubMed, Web of Science and Embase. RCTs assessing mortality,

  • intensive care unit (ICU) admission,
  • mechanical ventilation (MV),
  • length of hospitalization (LOH), and
  • inflammatory markers containing
    • C-reactive protein (CRP),
    • D-dimer,
    • interleukin-6 (IL-6),
    • lactate dehydrogenase (LDH) were included.

19 RCTs were involved in the analysis and were conducted subgroup analyses on the baseline COVID-19 severity and vitamin D administration.

Results: In the severity subgroup, statistically significant effects in moderate to severe group were observed in

  • ICU admission (OR 0.43, 95% CI 0.23, 0.80; p = 0.008),
  • MV (OR 0.44, 95% CI 0.27, 0.72; p = 0.001) and
  • LOH (SMD –0.49, 95% CI –0.92, −0.06; p = 0.027).

In the administration subgroup,

  • effects of ICU admission (OR 0.39, 95% CI 0.16, 0.97; p = 0.044),
  • MV (OR 0.18, 95% CI 0.07, 0.46; p = 0.000) and
  • LOH (SMD –0.50, 95% CI –0.96, −0.04; p = 0.034)

were more pronounced in patients supplied with multiple-dose vitamin D than single-dose. Although the result of mortality showed no statistically significant effect, it indicated a reduced trend (OR 0.87, 95% CI 0.63, 1.12; p > 0.05). The results of inflammatory markers reached no statistical differences.

Conclusion: This meta-analysis revealed that moderate to severe COVID-19 patients supplied with multiple doses of vitamin D were less apt to need ICU admission, mechanical ventilation and have shorter hospital stays.
 Download the PDF from VitaminDWiki
study was reviewed in Trial Site News

42 Virus Meta-analyses

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21289 COVID multi-dose.webp admin 09 Jun, 2024 8.27 Kb 33
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