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How Vitamin D treats Traumatic Brain Injury – July 2022

Vitamin D Protects against Traumatic Brain Injury via Modulating TLR4/MyD88/NF- κ B Pathway-Mediated Microglial Polarization and Neuroinflammation

Biomed Res Int. 2022 Jul 15;2022:3363036. doi: 10.1155/2022/3363036. eCollection 2022.
Hongsheng Jiang 1, Xinyu Yang 2, Yanzhou Wang 1, Caifeng Zhou 1



Vitamin D (VD) deficiency is associated with neuroinflammation and neurocognitive deficits in patients with traumatic brain injury (TBI). The present study was aimed at investigating the therapeutic effects of VD and the molecular mechanisms after TBI. After the intraperitoneal injection of VD (1 µg/kg), sensorimotor and cognitive function was assessed via a series of behavioral tests in TBI rats. Traumatic outcomes were investigated by brain edema, blood-brain barrier (BBB) disruption, and morphologic staining. In vitro, cellular viability and cytotoxicity in primary hippocampal neurons were detected via the MTT method and LDH release. Hippocampal oxidative stress-related enzymes and proinflammatory mediators and the serum concentration of VD were analyzed by ELISA. The expression of VDR, TLR4, MyD88, and NF-κ B p65 was measured by Western blot. Furthermore, the levels of M1/M2 microglial markers were quantified using real-time PCR and Western blot. VD treatment significantly increased the serum level of VD and the hippocampal expression of VDR.

VD not only effectively alleviated neurocognitive deficits, brain edema, and BBB disruption but also promoted hippocampal neuronal survival in vivo and in vitro. Moreover, VD therapy prevented excessive neuroinflammation and oxidative stress caused by TBI. Mechanically, the hippocampal expression of TLR4, MyD88, and nuclear NF-κ B p65 was elevated in the TBI group but robustly restrained by VD treatment. Taken together, VD provides an important neuroprotection through modulating hippocampal microglial M2 polarization and neuroinflammation via the TLR4/MyD88/NF-κ B pathway.
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VitaminDWiki pages with "Traumatic Brain Injury OR TBI" in title (21 as of July 2022)

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Items found: 21
Title Modified
How Vitamin D treats Traumatic Brain Injury – July 2022 26 Jan, 2023
40% less likely to recover from TBI with Intracranial Injury if low vitamin D – June 2022 09 Jun, 2022
Traumatic Brain Injury recovered faster if high vitamin D (review of 58 studies) – April 2021 09 Jun, 2022
Vitamin D3 Attenuates Blood-Brain Barrier Disruption due to TBI (in rats) – Feb 2021 23 Feb, 2021
Traumatic Brain Injury – 120,000 IU of Vitamin D resulted in 3 fewer days on ventilators – RCT March 2020 17 Mar, 2020
Traumatic Brain Injuries treated by Vitamin D etc (US patent) – interview Dec 2019 24 Dec, 2019
Preventing and treating TBI with Vitamin D, Magnesium Omega-3, Zinc, etc – book 2011 21 May, 2019
Vitamin B12 treats Traumatic Brain Injury in mice – April 2019 21 May, 2019
Traumatic Brain Injuries routinely treated by Vitamin D, Omega-3, Progesterone and Gluatmine 14 May, 2019
Traumatic Brain Injury recovery helped by injection of 100,000 IU of Vitamin D – March 2019 13 May, 2019
Spinal cord problems more likely if TBI if little Omega-3 in diet – June 2013 07 Oct, 2018
Dementia risk increased 2.4 X following TBI, even if had not lost consciousness – May 2018 12 May, 2018
5 Traumatic brain injuries resulted in 2.8 X increased risk of dementia – April 2018 10 Apr, 2018
Mild Traumatic Brain Injury prevented with Omega-3, Resveratrol, etc (in rats) – Oct 2017 10 Oct, 2017
Concussions (traumatic brain injury) getting big press coverage, vitamin D might be both a cause and a solution 21 Sep, 2017
Mild Traumatic Brain Injury reduced by Vitamin D – May 2014 07 Aug, 2017
Cognitive decline after traumatic brain injury reduced by Omega-3 (mice) – Nov 2016 06 Dec, 2016
Traumatic brain injury treated by Vitamin D Progesterone Omega-3 and glutamine – May 2013 10 Sep, 2016
High-fructose diet slows recovery from brain injury - TBI, rats - Oct 2015 30 Apr, 2016
Traumatic Brain Injury in military - vitamin D - 2014 08 Feb, 2016
Vitamin D aided progesterone in reducing traumatic brain injury – RCT Dec 2012 03 Jan, 2015

VitaminDWiki founder has kept emergency vitamin D in all vehicles since 2017

Head injury is associated with doubled mortality rate long-term - Jan 2023

2.2 X regular TBI, 2.8X if severe TBI
Medical Express - Jan 2023

Created by admin. Last Modification: Thursday January 26, 2023 20:35:13 GMT-0000 by admin. (Version 6)
How Vitamin D treats Traumatic Brain Injury – July 2022        
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18182 how treat TBI_CompressPdf.pdf PDF 2022 admin 25 Jul, 2022 17:40 509.39 Kb 108
18181 VDR TBI.jpg admin 25 Jul, 2022 17:40 32.92 Kb 240
18180 D drops aft TBI.jpg admin 25 Jul, 2022 17:39 38.84 Kb 290