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Preemies getting 800 IU of vitamin D were 3X less likely to have low bone density 4 weeks later – RCT Oct 2017


Randomized trial of two doses of vitamin D3 in preterm infants <32 weeks: Dose impact on achieving desired serum 25(OH)D3 in a NICU population.

PLoS One. 2017 Oct 10;12(10):e0185950. doi: 10.1371/journal.pone.0185950. eCollection 2017.
Anderson-Berry A1, Thoene M2, Wagner J3, Lyden E4, Jones G5, Kaufmann M5, Van Ormer M1, Hanson C6.

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BACKGROUND:
Recommendations for vitamin D supplementation for preterm infants span a wide range of doses. Response to vitamin D supplementation and impact on outcomes in preterm infants is not well understood.

OBJECTIVE:
Evaluate serum 25(OH)D3 concentration changes after 4 weeks in response to two different doses of vitamin D3 supplementation in a population of premature infants and quantify the impact on NICU outcomes.

DESIGN:
32 infants born at 24-32 weeks gestation were prospectively randomized to receive 400 or 800 IU/day vitamin D3 supplementation. Serum 25(OH)D3 levels were measured every 4 weeks. The Wilcoxon signed rank test was used to compare serum levels of 25(OH)D3 at 4 weeks and each subsequent time point. A p-value of <0.05 was considered statistically significant.

RESULTS:
Serum 25(OH)D3 levels at birth were 41.9 and 42.9 nmol/l for infants in the 400 IU group and 800 IU group, respectively (p = 0.86). Cord 25(OH)D3 concentrations significantly correlated with gestational age (r = 0.40, p = 0.04). After 4 weeks of D3 supplementation, median 25(OH)D3 levels increased in both groups (84.6 vs. 105.3 nmol/l for 400 vs. 800 IU/day respectively, with significantly more improvement in the higher dose (p = 0.048). Infants in the 400 IU group were significantly more likely to have dual energy x-ray absorptiometry (DEXA) bone density measurements <10 percentile (56% vs 16%, p = 0.04).

CONCLUSIONS:
Improvement in 25(OH)D3 levels at 4 weeks, bone density, and trends towards improvement in linear growth support consideration of a daily dose of 800 IU of vitamin D for infants <32 weeks cared for in the NICU.


Note: 400 IU and 800 IU had virtually same Vitamin D levels after 4 weeks, but 800 IU preemies had much better bone density


22+ VitaminDWiki Infant/Child pages with PREEMIE OR PREMATURE in the title

This list is automatically updated

Items found: 22
Title Modified
Preemies with pneumonia infection have especially low vitamin D levels (12 ng) – May 2023 08 Oct, 2023
Preemies should have vitamin D supplements – reaching an agreement – April 2021 01 May, 2021
Preemie Respiratory Distress Syndrome is 5X more likely if low vitamin D – Dec 2020 18 Dec, 2020
Preemies still have low vitamin D at age 6 – Oct 2019 30 Oct, 2019
No preemie had even 30 ng of vitamin D, lower D associated with more Respiratory Distress – Aug 2013 24 Jul, 2019
Preemie immunity (Treg) vastly improved by 800 IU of Vitamin D daily – RCT July 2019 24 Jul, 2019
Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019 15 Feb, 2019
60 percent of preemies have brain damage from lack of brain Oxygen, which is associated with low vitamin D – Feb 2018 22 Feb, 2018
Born too soon – premature births report by W.H.O. – 2010 26 Nov, 2017
Preemies with poor lungs (Respiratory distress syndrome) have low levels of vitamin D – Nov 2017 14 Nov, 2017
Preemies getting 800 IU of vitamin D were 3X less likely to have low bone density 4 weeks later – RCT Oct 2017 22 Oct, 2017
Preemies need 1,000 IU of vitamin D – RCT Sept 2017 03 Aug, 2017
Premature infants (30 weeks) who got 800-1000 IU of vitamin D were much healthier – March 2017 03 Aug, 2017
Preemies with low Vitamin D are 14 percent more like to have expensive gut problems (necrotizing enterocolitis) – March 2017 24 Mar, 2017
Premature infants need 400 to 800 IU of vitamin D 13 Apr, 2016
Preemies have increased need for vitamin D and Calcium (Rickets)– May 2013 15 Mar, 2016
All preemies with Chronic Lung Disease had low vitamin D levels– July 2015 01 Aug, 2015
Many preemies need at least 800 IU of vitamin D – RCT May 2013 16 Mar, 2015
Preemies have low vitamin D levels yet only get 400 IU – July 2013 15 Aug, 2014
Study found little proof that preemies need more vitamin D – Sept 2013 15 Sep, 2013
Some preemies needed more than 400 IU of vitamin D – July 2013 12 Aug, 2013
400 IU not enough to raise preemies vitamin D level to 30 ng – Dissertation 2010 01 Jun, 2013

Created by admin. Last Modification: Sunday October 8, 2023 21:42:44 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
8575 Premie bone density.pdf admin 22 Oct, 2017 1.27 Mb 1675