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Some ICU patients got 540,000 IU of Vitamin D: good responders lived longer than controls or poor responders – RCT June 2024

Efficacy and safety of enteral supplementation with high-dose vitamin D in critically ill patients with vitamin D deficiency

Journal of the Formosan Medical Association https://doi.org/10.1016/j.jfma.2024.05.005
An-Yi Wang a b, Yu-Chang Yeh c, Kuang-Hua Cheng d e, Yin-Yi Han f, Ching-Tang Chiu c, Chai-Chi Chang c, I-Ting Wang d 1, Anne Chao c 1

Vitamin D deficiency is associated with mortality and morbidity in critically ill patients. This study investigated the safety and effectiveness of enteral high-dose vitamin D supplementation in intensive care unit (ICU) patients in Asia.

This was a multicenter, prospective, randomized-controlled study. Eligible participants with vitamin D deficiency were randomly assigned to the control or vitamin D supplementation group. In the vitamin D supplementation group, the patients received 569,600 IU vitamin D. The primary outcome was the serum 25(OH)D level on day 7.

41 and 20 patients were included in the vitamin D supplementation and control groups, respectively. On day 7, the serum 25(OH)D level was significantly higher in the vitamin D supplementation group compared to the control group (28.5 IQR: 20.2–52.6 ng/mL and 13.9 IQR: 11.6–18.8 ng/mL, p < 0.001). Only 41.5% of the patients achieved serum 25(OH)D levels higher than 30 ng/mL in the supplementation group. This increased level was sustained in the supplementation group on both day 14 and day 28. There were no significant adverse effects noted in the supplementation group. Patients who reached a serum 25(OH)D level of >30 ng/mL on day 7 had a significantly lower 30-day mortality rate than did those who did not (5.9% vs 37.5%, p < 0.05).

In our study, less than half of the patients reached adequate vitamin D levels after the enteral administration of high-dose vitamin D. A reduction in 30-day mortality was noted in the patients who achieved adequate vitamin D levels.
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VitaminDWiki – Trauma and surgery category contains:

Trauma and Surgery category has 335 articles

Large dose Vitamin D before surgery was found to help by 35 studies
Vitamin D is needed before most surgeries – many studies and RCTs
4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
Sepsis is both prevented and treated by Vitamin D - many studies
Thyroidectomy and Vitamin D - many studies
Orthopaedic surgeries need Vitamin D – many studies
Cancer - After diagnosis   chemotherapy
TBI OR "Traumatic Brain Injury - 21 in title as of Sept 2022
Superbug (Clostridium difficile) Infections strongly associated with low vitamin D - many studies
Glutamine and Omega-3 have also been proven to help several traumas/surgeries
   Note: Vitamin D also prevents the need for various surgeries and Omega-3 prevents many concussions/TBI
Trauma and Surgery is associated with 22 other VitaminDWiki categories
  Such as loading dose 33, Mortality 23, Infant-Child 21 Intervention 19 Cardiovascular 13, Injection 13 in Sept 2022

Did you know?

  • You can easily improve outcomes of many planned surgeries by increasing vitamin D ahead of time
    • Cancer surgery is the only known exception - extra Vitamin D is OK only if doctor reduces the chemo doses
  • A loading dose of Vitamin D also improves unplanned hospital admissions
  • Improvements include
    • Shorter recovery time
    • Shorter ICU time
    • Reduced deaths – in hospital, next month, next year
    • Reduced Sepsis = blood poisoning = infection

18+ VitaminDWiki Loading Dose pages have ICU in the title

This list is automatically updated

Items found: 18
Title Modified
Some ICU patients got 540,000 IU of Vitamin D: good responders lived longer than controls or poor responders – RCT June 2024 07 Jun, 2024
Single 600,000 IU dose of nanoemulsion Vitamin D is safe and effective to fight COVID, even if delay until enter ICU – RCT May 2024 01 Jun, 2024
ICU Vitamin D injection (300,000 IU) helped - RCT Feb 2021 21 Aug, 2021
600,000 IU of Vitamin D helped 26 out of 28 COVID-19 patients in ICU (Brazil and Bolivia) June 2021 22 Jun, 2021
ICU mortality reduced by non-oral vitamin D – meta-analysis May 2021 23 May, 2021
Those getting an injection of 300,000 IU Vitamin D got out of the ICU a week sooner – RCT Dec 2020 07 Jan, 2021
Vitamin D has eliminated ICU COVID-19 in hospital in Dubai since June - Sept 26, 2020 04 Dec, 2020
ICU patients greatly helped by Vitamin D loading doses – if gut-friendly – Oct 2020 18 Oct, 2020
Fewer days in ICU after 300,000 IU of vitamin D, but not 540,000 – meta-analysis Aug 2020 02 Sep, 2020
ICU survival increased with vitamin D single 540K IU loading dose - JAMA Sept 2014 25 Jul, 2020
10 fewer days of ICU Mechanical Ventilation 300,000 IU injection of vitamin D – RCT March 2019 18 Jul, 2020
Rapidly restore Vitamin D levels with 10,000 IU per kg for children in ICU – RCT 2024 11 Feb, 2020
Intensive Care (ICU) helped by Vitamin D – review of past and on-going studies – Dec 2018 14 Jun, 2019
ICU adults getting 540,000 IU of Vitamin D were 2X more likely to be alive 30 days later – RCT June 2019 06 Jun, 2019
Vitamin D loading doses reduce ICU mortality by 30 percent – meta-analysis April 2017 20 May, 2017
Hospital ICU added high dose vitamin D - malpractice lawsuit costs dropped from 26 million dollars to ZERO - Oct 2016 20 Nov, 2016
VITdAL-ICU - AMA RCT Sept 2014 21 Jan, 2015
540000 IU before ICU raised vitamin D by 25 ng in 2 days – March 2011 02 May, 2014

Attached files

ID Name Comment Uploaded Size Downloads
21282 response to 500K.webp admin 07 Jun, 2024 16.89 Kb 48
21281 ICU shorter stay with 540K.pdf admin 07 Jun, 2024 294.62 Kb 23