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Preterm birth 7 X more likely if both low vitamin D and high PTH 1 month before birth – May 2023


Post-hoc Analysis of NICHD Vitamin D Pregnancy Cohort and The Role of Functional Vitamin D Deficiency in Pregnancy

Am J Perinatol. 2023 May 22. doi: 10.1055/a-2097-2098 PDF is behind paywall
Shellie Davis 1, Elliott Lyles 2, Judy Shary 3, Myla Ebeling 4, Susan G Reed 1, John E Baatz 1, Bruce W Hollis 3, Carol L Wagner 1

Objective: Conduct a secondary, post-hoc analysis of NICHD vitamin D (vitD) pregnancy study by Hollis et al. (Hollis, 2011), which reported on the effect of vitD supplementation in pregnant women; and determine the potential interaction between intact parathyroid hormone (iPTH) concentrations, vitD status, and various comorbidities associated with pregnancy.

Hypothesis: Women with low 25(OH)D concentrations and high iPTH concentrations during pregnancy, known as functional vitD deficiency (FVDD), were more likely to acquire complications also affecting their neonates.

Study design: This post-hoc analysis of data collected from a diverse group of pregnant women participating in the NICHD vitD pregnancy study, was applied to investigate the applicability of the concept of FVDD in pregnancy (Hemmingway, 2018) in identifying potential risks for certain comorbidities of pregnancy. This analysis defines FVDD as maternal serum 25(OH)D concentrations below 20 ng/mL and iPTH concentrations above 65 pg/mL creating a definitive ratio number, 0.308, to classify mothers as having FVDD prior to delivery (PTD). Statistical analyses were performed using SAS 9.4 (Cary, NC).

Results: 281 women (85 African American, 115 Hispanic, 81 Caucasian) with 25(OH)D and iPTH concentrations measured at monthly visits were included in this analysis. No statistically significant association was found between mothers classified as having FVDD at baseline or one-month PTD and hypertensive disorders of pregnancy, infection, or admittance to the NICU. When combining all comorbidities of pregnancy in this cohort, results showed those with FVDD at baseline, 24 weeks' gestation, and one-month PTD were more likely to experience a comorbidity (p=0.001; p=0.001; p=0.004, respectively).
Those with FVDD one-month PTD were 7.1 times (CI 1.71-29.81) more likely to have preterm birth (<37 weeks) than women without FVDD.

Conclusions: Participants were more likely to have experienced preterm birth if they met the criteria for FVDD. This study supports the importance of FVDD during pregnancy.


VitaminDWiki pages with PRE-TERM etc in title (116 as of May 2023)

This list is automatically updated

Items found: 117
Title Modified
Preemies with pneumonia have especially low vitamin D levels (12 ng) – May 2023 23 May, 2023
Preterm birth 7 X more likely if both low vitamin D and high PTH 1 month before birth – May 2023 23 May, 2023
Omega-3 supplementation reduced preterm birth rate by 4X – RCT July 2020 21 Oct, 2022
Preterm birth decreased by Omege-3, etc. - many studies 21 Oct, 2022
4.4 X more likely to have a preterm birth if low vitamin D while pregnant - May 2022 23 May, 2022
Arab preterm infants often have less than 10 ng of vitamin D - 2010 15 May, 2022
Preterm birth interventions – 4 studies found possible vitamin D benefit – Cochrane – Nov 2018 15 May, 2022
Preterm birth might be prevented by Vitamin D, Omega-3, etc. (International survey) – Jan 2019 15 May, 2022
Preterm Births - promising preventions – anti-oxidants, Vitamin D, Omega-3, Zinc, etc. – Jan 2019 15 May, 2022
Preterm birth chance reduced – with 17P or Vitamin D – June 2015 15 May, 2022
Preterm birth reduction by nutrients - Vitamin D is the best, Omega-3 is next best – May 2022 15 May, 2022
Preterm birth rate of pregnant smokers cut in half if take Omega-3 – RCT May 2017 20 Feb, 2022
Preterm birth varies with season: 25 percent more likely if conception in autumn – Feb 2022 04 Feb, 2022
Supplement preterm infants with vitamin D if less than 80 ng – RCT Sept 2021 28 Sep, 2021
Preterm infants need Vitamin D 04 Aug, 2021
Pre-term birth rate cut in half with 1000 milligrams of Omega-3 (if initially low) – RCT May 2021 04 Jun, 2021
Preemies should have vitamin D supplements – reaching an agreement – April 2021 01 May, 2021
Preemies 2.5 X more likely to get hip replacement etc. (low vitamin D) – Nov 2014 30 Apr, 2021
Preemie Respiratory Distress Syndrome is 5X more likely if low vitamin D – Dec 2020 18 Dec, 2020
Preterm birth risk increased 16 pcnt if heat wave (perhaps outside less) - Nov 2020 16 Nov, 2020
Preterm birth associated with many genes, including the Vitamin D Receptor again – Jan 2020 30 Jan, 2020
Preterm birth 8X more likely if poor Vitamin D Receptor – Dec 2019 31 Dec, 2019
8 percent fewer preterm births if adequate Selenium from food – Aug 2019 24 Dec, 2019
Pregnant women in Australia to take Omega-3 when told of reduction in preterm births – Dec 2019 19 Nov, 2019
Preterm birth 9 X more likely if fetus had a poor Vitamin D Receptor and previous miscarriage – Aug 2017 12 Nov, 2019
Preemies still have low vitamin D at age 6 – Oct 2019 30 Oct, 2019
Preterm births reduced by Vitamin D, Omega-3, Zinc – Oct 2019 26 Oct, 2019
Preterm birth rate not vary with vitamin D level (when all are less than 30 ng) – Oct 2019 17 Oct, 2019
Extreme preterm infants helped somewhat by 800 IU of vitamin D – RCT Jan 2018 01 Oct, 2019
Preterm Births reduced by Omega-3, Zinc, and Vitamin D – Aug 2019 09 Aug, 2019
Preterm birth increases risk of heart disease by 1.5 X by age 40 – June 2019 06 Aug, 2019
No preemie had even 30 ng of vitamin D, lower D associated with more Respiratory Distress – Aug 2013 24 Jul, 2019
Preemie immunity (Treg) vastly improved by 800 IU of Vitamin D daily – RCT July 2019 24 Jul, 2019
Rickets in Sweden recently increased by 6X (mainly preemies) – May 2019 06 May, 2019
Preterm Births decreased by Omega-3 (analysis of 184 countries) – April 2019 27 Apr, 2019
Vaginal microbiome varies with race, vitamin D level, preterm birth, etc. - March 2019 27 Mar, 2019
Premature births predicted in office by 2024 - Bill Gates (vs. reduce preemies by half now with Vitamin D) - Feb 2019 28 Feb, 2019
Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019 15 Feb, 2019
Preterm birth 3X more likely if low vitamin D – Oct 2018 07 Feb, 2019
Omega-3 index of 5 greatly decreases the risk of an early preterm birth – Dec 2018 04 Jan, 2019
Preterm babies have low vitamin D, but recover in 6 weeks with 800 IU supplementation – Jan 2019 01 Jan, 2019
Preterm birth cost for employers approximately 50,000 dollars – Oct 2017 28 Sep, 2018
Preterm births 12 X more likely if poor Vitamin D Receptor (white infants in Italy) – meta-analysis Aug 2018 27 Aug, 2018
Autism and ADHD type disorders were 14X more likely in survey of extreme preterm vaccinated infants - April 2017 04 Jul, 2018
FDA petitioned to acknowledge that vitamin D cuts preterm birth rate in half – May 2018 13 May, 2018
Preterm birth 4X more likely if Vitamin D deficient – Feb 2018 04 Apr, 2018
Third trimester Vitamin D levels were lower if pre-term labor was expected – March 2018 24 Mar, 2018
Preterm birth 4X more likely if very low Vitamin D (Chinese) - Feb 2018 28 Feb, 2018
60 percent of preemies have brain damage from lack of brain Oxygen, which is associated with low vitamin D – Feb 2018 22 Feb, 2018
Pregnancies with more than 40 ng of vitamin D are great - miscarriage, LBW, SGA, preterm – Feb 2018 14 Feb, 2018
Pregnancies with more than 40 ng of vitamin D are great - miscarriage, LBW, SGA, preterm – Feb 2018 14 Feb, 2018
Preterm birth rates increased in 15 European countries – Oct 2013 23 Dec, 2017
Increasing Omega-3 reduces heart problems, autism, depression, preterm birth, breast cancer, etc. 15 Dec, 2017
Vitamin D intervention reduces preterm births and low birth weight by 60 percent – Cochrane Reviews – Nov 2017 07 Dec, 2017
Preterm birth rate increased 60 percent in 50 years (US) 26 Nov, 2017
Preterm cost for employers, increased 65 percent in 2 years – Oct 2017 26 Nov, 2017
Preterm births are VERY costly – Feb 2017 26 Nov, 2017
Preterm birth far more likely if previous miscarriage and poor Vitamin D receptor – Aug 2017 20 Nov, 2017
Preemies with poor lungs (Respiratory distress syndrome) have low levels of vitamin D – Nov 2017 14 Nov, 2017
Preterm birth is related to Vitamin D Receptor problems – many studies agree 13 Nov, 2017
Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc 13 Nov, 2017
Preterm birth and Vitamin D Receptor – Dec 2016 13 Nov, 2017
Vitamin D Receptor is associated with preeclampsia, gestational diabetes and preterm birth – Nov 2017 10 Nov, 2017
Preemies getting 800 IU of vitamin D were 3X less likely to have low bone density 4 weeks later – RCT Oct 2017 22 Oct, 2017
APS (associated with miscarriage, stillbirth. preterm delivery and stroke) is 3X more likely if low vitamin D – meta-analysis Oct 2017 13 Oct, 2017
Preterm birth trend toward 2.5 X more likely if less than 10 ng of Vitamin D – Aug 2017 26 Aug, 2017
Preemies need 1,000 IU of vitamin D – RCT Sept 2017 03 Aug, 2017
Preterm birth rate reduced by vitamin D – 78 percent if non-white, 39 percent if white – July 2017 27 Jul, 2017
Preterm birth more likely if dark skinned and low vitamin D (not white-skinned) – April 2017 06 Jul, 2017
Dark skinned Canadian women with low vitamin D are 4 X more likely to have preterm births – April 2017 06 Jul, 2017
Preterm birth 2X more likely if poor Vitamin D Receptor, 9 X if also had previous miscarriage – June 2017 15 Jun, 2017
Sepsis in first year of life is much more likely if preterm (low Vitamin D) – May 2017 10 May, 2017
Iodine added during pregnancy reduces preterm births, increases IQ. Etc. 27 Apr, 2017
Risk of preterm birth twice as likely when less than 10 ng of vitamin D – Nov 2016 13 Apr, 2017
Preemies with low Vitamin D are 14 percent more like to have expensive gut problems (necrotizing enterocolitis) – March 2017 24 Mar, 2017
Preterm labor 20 times more likely if low vitamin D, etc. (India) – Feb 2017 08 Mar, 2017
Preterm birth rate reduced by 43 percent with adequate Vitamin D supplementation – meta-analysis Feb 2017 02 Mar, 2017
Preterm birth rate reduced by 0.57 with adequate Vitamin D supplementation – meta-analysis Feb 2017 28 Feb, 2017
Pre-term birth - many of risk factors are associated with low vitamin D 27 Feb, 2017
Preterm birth rate reduced 57 percent by Vitamin D – Nov 2015 23 Jan, 2017
Vitamin D Webinar - cost of pre-term birth etc- Baggerly Nov 2013 11 Dec, 2016
Preterm birth extended by 2 weeks with Omega-3 – Meta-analysis Nov 2015 10 Dec, 2016
Preterm birth 3.3 times more likely if Vitamin D Receptor gene problem – Aug 2016 15 Oct, 2016
Omega-3 supplementation during pregnancy reduce early preterm births (save 1500 USD per child) – Aug 2016 12 Oct, 2016
Zinc helps pregnancies – 14 percent fewer preterm births, etc. – Cochrane RCT Feb 2015 14 Jun, 2016
Preterm birth has become the leading cause of infant mortality (vitamin D not mentioned) – JAMA June 2016 07 Jun, 2016
Preterm birth 30 percent more likely if low vitamin D – meta-analysis May 2016 20 May, 2016
Extreme preterm infants need a total of 1,000 IU of vitamin D daily – RCT April 2016 13 Apr, 2016
Preemies have increased need for vitamin D and Calcium (Rickets)– May 2013 15 Mar, 2016
Asthmatic pregnant women had 30 percent more preterm births if air pollution (vitamin D not mentioned) – March 2016 09 Mar, 2016
Omega-3 helps pregnancy in many ways: preterm 26 percent less likely etc – review July 2012 08 Sep, 2015
Extreme preterm survival 30 percent less likely if little sunshine 23-28 weeks – June 2015 05 Sep, 2015
Magnesium (Sulfate) reduces risk of cerebral palsy for those at risk of pre-term births – Dec 2013 18 Aug, 2015
Respiratory distress after preterm birth is more likely if low vitamin D – review April 2015 05 Aug, 2015
All preemies with Chronic Lung Disease had low vitamin D levels– July 2015 01 Aug, 2015
Many preemies need at least 800 IU of vitamin D – RCT May 2013 16 Mar, 2015
Pre-term births reduced in half if 40 ng of vitamin D in 3rd trimester – Nov 2014 15 Mar, 2015
Preterm births are associated most strongly with low vitamin D in third trimester – Nov 2014 13 Mar, 2015
Chance of preterm birth is strongly associated with low vitamin D – Feb 2015 05 Feb, 2015
The more preterm the birth, the lower the vitamin D level (both mothers and infants) – Feb 2014 05 Feb, 2015
Preterm infants more likely to have vitamin D levels below 20 ng – Feb 2014 05 Feb, 2015
Decreased risk of preterm birth if have more than 36 ng of vitamin D – Jan 2015 09 Jan, 2015
Autism associated with preterm and low birth weight (both associated with low vitamin D) – Nov 2014 31 Dec, 2014
Preterm infants, kidney, rickets and vitamin D intake: is it time for rewriting the history – Aug 2014 26 Aug, 2014
Preemies have low vitamin D levels yet only get 400 IU – July 2013 15 Aug, 2014
Fewer pre-term births after pollution reduction (vitamin D not mentioned) April 2014 16 Jun, 2014
300 IU is not enough vitamin D for preterm infants – March 2014 22 Apr, 2014
Pre-term birth 3X more likely and C-section 4X if less than 20 ng of vitamin D – May 2012 13 Feb, 2014
Morbid obesity increases chance of extreme preemie by 3X (low vitamin D not mentioned) – June 2013 21 Sep, 2013
Study found little proof that preemies need more vitamin D – Sept 2013 15 Sep, 2013
Some preemies needed more than 400 IU of vitamin D – July 2013 12 Aug, 2013
400 IU not enough to raise preemies vitamin D level to 30 ng – Dissertation 2010 01 Jun, 2013
Recurrent pre term birth and low vitamin D – Dec 2012 23 Jan, 2013
Osteopenia in preterm infants – May 2012 27 Dec, 2012
Blacks have more pre-term births due to low nutrients such as vitamin D – Sept 2011 14 Sep, 2011
Pre-term birth not associated with first tri-mester vitamin D – April 2011 21 Apr, 2011
Dark-skin plus low vitamin D in first trimester made preterm birth 2.9 X more likely – Dec 2019 No value for &#039;modification_date_major&#039;

VitaminDWiki - Pregnancy category contains

859 items in Pregnancy category

 - see also


VitaminDWiki - Healthy pregnancies need lots of vitamin D contains

Problem
ReducesEvidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial


Rick of Preterm Birth increases about 1% for each excess degree increase in temperature - Aug 2023

Extreme Heat Threatens the Health of Unborn Babies Wired Magazine

  • Previously noticed in livestock studies
  • Stillbirth increase by 40% if moderate heat stress (32 degrees Celsius) in the last two weeks of pregnancy.