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Vitamin D interactions with poor gut (Celiac, IBD, and Bariatric surgery) – Feb 2023

Vitamin D and malabsorptive gastrointestinal conditions: A bidirectional relationship?

Reviews in Endocrine and Metabolic Disorders https://doi.org/10.1007/s11154-023-09792-7
Andrea Giustina1,2 • Luigi di Filippo1 • Agnese Allora1 • Daniel D. Bikle3 • Giulia Martina Cavestro4 •
David Feldman5 • Giovanni Latella6 • Salvatore Minisola7 • Nicola Napoli8 • Silvia Trasciatti9 • Melin Uygur1,10 •

PDF Table of Contents



This paper is one of the outcomes of the 5 th International Conference "Controversies in Vitamin D" held in Stresa, Italy from 15 to 18 September 2021 as part of a series of annual meetings which was started in 2017. The scope of these meetings is to discuss controversial issues about vitamin D. Publication of the outcomes of the meeting in international journals allows a wide sharing of the most recent data with the medical and academic community. Vitamin D and malabsorptive gastrointestinal conditions was one of the topics discussed at the meeting and focus of this paper. Participants to the meeting were invited to review available literature on selected issues related to vitamin D and gastrointestinal system and to present their topic to all participants with the aim to initiate a discussion on the main outcomes of which are reported in this document. The presentations were focused on the possible bidirectional relationship between vitamin D and gastrointestinal malabsorptive conditions such as celiac disease, inflammatory bowel diseases (IBDs) and bariatric surgery. In fact, on one hand the impact of these conditions on vitamin D status was examined and on the other hand the possible role of hypovitaminosis D on pathophysiology and clinical course of these conditions was also evaluated. All examined malabsorptive conditions severely impair vitamin D status. Since vitamin D has known positive effects on bone this in turn may contribute to negative skeletal outcomes including reduced bone mineral density, and increased risk of fracture which may be mitigated by vitamin D supplementation. Due to the immune and metabolic extra-skeletal effects there is the possibility that low levels of vitamin D may negatively impact on the underlying gastrointestinal conditions worsening its clinical course or counteracting the effect of treatment. Therefore, vitamin D status assessment and supplementation should be routinely considered in all patients affected by these conditions. This concept is strengthened by the existence of a possible bidirectional relationship through which poor vitamin D status may negatively impact on clinical course of underlying disease. Sufficient elements are available to estimate the desired threshold vitamin D level above which a favourable impact on the skeleton in these conditions may be obtained. On the other hand, ad hoc controlled clinical trials are needed to better define this threshold for obtaining a positive effect of vitamin D supplementation on occurrence and clinical course of malabsorptive gastrointestinal diseases.
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8+ VitaminDWiki pages with CELIAC in title

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Items found: 9

28+ VitaminDWiki pages with IBD in title

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Items found: 29
Title Modified
Vitamin D interactions with poor gut (Celiac, IBD, and Bariatric surgery) – Feb 2023 23 Feb, 2023
IBD treated in children by Vitamin D, especially if use more than 2,000 IU daily for 12 weeks – meta-analysis – Sept 2022 14 Sep, 2022
Vitamin D fights IBD, no consensus yet on dose size and type – Aug 2022 26 Aug, 2022
IBD is treated by Vitamin D and other Nutraceuticals – June 2022 23 Jun, 2022
IBD (Colitis, Crohn’s) was active 6X more often if low vitamin D – June 2015 30 May, 2022
IBD in children might be associated with low sun exposure 28 Feb, 2022
IBD strongly associated with low Vitamin D – Jan 2022 09 Jan, 2022
IBD and Crohn's patients need Vitamin D, even to increase drug efficacy (Vedolizumab) June 2021 29 Jun, 2021
IBD and UV dissertation - 2019 10 Sep, 2019
Vitamin D appears to fight Diabetes, MS, RA, Lupus, IBD, Hepatitis, Cancer, Psoriasis, Food allergy, etc – June 2019 17 Jul, 2019
IBD in Finland – 3X increase in 15 years, more prevalent further from equator – Nov 2012 14 May, 2019
Common cold incidence reduced by two thirds (500 IU for IBD with low vitamin D) – RCT Jan 2019 04 Jan, 2019
Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor – Aug 2018 09 Dec, 2018
IBD relapse rate reduced by low Vitamin D - meta-analysis Nov 2018 27 Nov, 2018
Higher Vitamin D increased the benefit of anti-TNF- α drug used for IBD by 2.6 times – Jan 2017 31 Jan, 2017
IBD in Canadian children increasing 7% per year - Nov 2016 22 Nov, 2016
IBD UC and CD at risk of being vitamin D deficient – May 2011 04 Nov, 2016
IBD deficiencies of Iron and Vitamin D (and new Iron types) – June 2016 20 Jun, 2016
IBD helped by vitamin D but reluctant to state who helped, in what form, and how much – review Nov 2014 08 Jan, 2016
IBD more likely in areas with low UV ( and thus low vitamin D) – June 2014 05 Dec, 2015
Gut problems more likely if low vitamin D (IBD: 1.6, UC: 2.3) – meta-analysis Aug 2015 31 Oct, 2015
IBD (Collitis, Chron’s) was active 6X more often if low vitamin D – June 2015 03 Oct, 2015
Crohn’s disease deficient in vitamin K – IBD deficient in vitamins K and D – April 2011 17 Feb, 2015
Appears that IBD lowers vitamin D, which increases risk of cancer by 80 percent – Oct 2013 09 Jul, 2014
IBD surgery 5X more likely for non-caucasians with low vitamin D – Oct 2012 03 Nov, 2012
IBD and Crohn but not Colitis associated with low vitamin D – May 2011 05 Jun, 2012
IBD colorectal Cancer and vitamin D – Jan 2011 14 Mar, 2012
Dogs – like humans – with IBD were low on vitamin D – July 2011 14 Mar, 2012
IBD less costly when treated with vitamin D3 compared to D2 – Jan 2012 12 Jan, 2012

12+ VitaminDWiki pages with BARIATRIC in title

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Items found: 14

VitaminDWiki – Overview Gut and vitamin D has

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 191 items

VitaminDWiki – Overview Gut and vitamin D contains gut-friendly information__

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart

Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into bloodstream
   you can make your own sublinqual by dissovling Vitamin D in water or using nanoemulsion form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into bloodstream. Prescription only?
Bio-Tech might be usefulit is also water soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection ($$$)
or Calcidiol or Calcitriol
D - Slow
C -Fast
10 Sun/UVBSlowLong
(skin patch/cream, vagina)
Fast nano
9Nanoemulsion -mucosal
perhaps activates VDR
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
(some goes into gut)
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

VitaminDWiki –Gut category contains

191 items in GUT category - see also Overview Gut and vitamin D, See also Microbiome category listing has 32 items along with related searches.

Attached files

ID Name Comment Uploaded Size Downloads
19271 Relationships.jpg admin 23 Feb, 2023 12:45 100.84 Kb 138
19270 Occurance and Incidence.jpg admin 23 Feb, 2023 12:45 42.22 Kb 133
19269 Bidirectional Chart.jpg admin 23 Feb, 2023 12:45 94.16 Kb 145
19268 ToC bidirectional.jpg admin 23 Feb, 2023 12:44 67.43 Kb 143
19267 Vitamin D and malabsorptive gastrointestinal conditions - bidirectional_CompressPdf.pdf PDF 2023 admin 23 Feb, 2023 12:44 411.02 Kb 62