Toggle Health Problems and D

Epigenetics and Vitamin D – many studies

18+ VitaminDWiki pages with EPIGENETICS in the title

This list is automatically updated

Items found: 18

Evidence in support of the Strong Epigenetic Theory of Aging - Oct 2020

Mice have 800,000 sites, of which just over 20% change significantly with age.

  • "...there are 10x (!) more gene pathways where methylation increases with age, which usually correlates with a decrease in gene expression, than pathways where the opposite happens"

Vitamin D, COPD, and Epigenetics – Aug 2011

Vitamin D and Susceptibility of Chronic Lung Diseases: Role of Epigenetics.
Front Pharmacol. 2011;2:50
Sundar IK, Rahman I.
Lung Biology and Disease Program, Department of Environmental Medicine, University of Rochester Medical Center Rochester, NY, USA.

Vitamin D deficiency is linked to accelerated decline in lung function, increased inflammation, and reduced immunity in chronic lung diseases. Epidemiological studies have suggested that vitamin D insufficiency is associated with low lung function in susceptible subjects who are exposed to higher levels of environmental agents (airborne particulates). Recent studies have highlighted the role of vitamin D and vitamin D receptor (VDR) in regulation of several genes that are involved in inflammation, immunity, cellular proliferation, differentiation, and apoptosis.

Vitamin D has also been implicated in reversal of steroid resistance and airway remodeling, which are the hallmarks of chronic obstructive pulmonary disease (COPD) and severe asthma. VDR protein level is decreased in lungs of patients with COPD. VDR deficient mice develop an abnormal lung phenotype with characteristics of COPD, such as airspace enlargement and decline in lung function associated with increased lung inflammatory cellular influx, and immune-lymphoid aggregates formation.

Dietary vitamin D may regulate epigenetic events, in particular on genes which are responsible for COPD susceptibility. Active metabolite of vitamin D, 1,25-dihydroxyvitamin D(3) plays an essential role in cellular metabolism and differentiation via its nuclear receptor (VDR) that cooperates with several other chromatin modification enzymes (histone acetyltransferases and histone deacetylases), thereby mediating complex epigenetic events in vitamin D signaling and metabolism.

This review provides an update on the current knowledge and understanding on vitamin D, and susceptibility of chronic lung diseases in relation to the possible role of epigenetics in its molecular action. Understanding the molecular epigenetic mechanism of vitamin D/VDR would provide rationale for dietary vitamin D-mediated intervention in prevention and management of chronic lung diseases linked with vitamin D deficiency.
see wikipage http://www.vitamindwiki.com/tiki-index.php?page_id=2047
 Download the PDF from VitaminDWiki.

See also VitaminDWiki

There have been 15391 visits to this page

Attached files

ID Name Comment Uploaded Size Downloads
781 Vitamin D, COPD, and Epigenetics - Aug 2011.pdf admin 28 Sep, 2011 1.51 Mb 1462