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Bone Mineral Density and Vitamin D - many studies

29+ VitaminDWiki pages with BONE MINERAL DENSITY or BMD in the title

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Items found: 29
Title Modified
Vitamin D during pregnancy increased child’s bone mineral density – meta-analysis April 2023 27 Apr, 2023
Bone Mineral Density and Vitamin D - many studies 13 Apr, 2023
Transgender associated with autism, low vitamin D, low BMD, etc. - many studies 05 Apr, 2023
Bone mineral density improvement by Vitamin D plus fluoride is augmented by laser acupuncture – RCT March 2023 22 Mar, 2023
Perhaps higher risk of fracture if low BMD plus low vitamin D – July 2022 08 Jul, 2022
Exercise improves bone strength (good), but not bone mineral density (can be measured) – RCT Oct 2021 08 Oct, 2021
Bone Mineral Density increased by Resveratrol (which activates the Vitamin D Receptor) – RCT Nov 2020 17 Feb, 2021
Low bone mineral density is inversely associated with both Vitamin D and Resistin (resistance to insulin) 15 Jan, 2021
Breast Cancer chemo reduces Bone Mineral Density, injecting Vitamin D increases it – Sept 2019 07 Sep, 2019
Bone mineral density somewhat better with 3750 IU vs 600 IU Vitamin D (1 year, with Calcium) – RCT March 2017 10 Mar, 2017
Low bone mineral density of male children is associated with low BMD of parents – Oct 2016 18 Oct, 2016
Osteoporosis vitamin D workshop - but still test BMD first - Oct 2010 19 Jan, 2016
Bone strength (more accurate than BMD) is inversely associated with vitamin D level – May 2015 30 May, 2015
Long bone fracture – prediction by low vitamin D is better than low BMD – Sept 2014 16 May, 2015
Hypothesis: increased bone mineral density needs protein, Ca, Mg, Vitamin D and K 28 Oct, 2014
Increasing bone mineral density increases breast cancer by at least 2X – Aug 2012 26 Oct, 2014
600,000 IU intramuscular D3 helped BMD after pancreatic surgery – June 2010 24 Jan, 2014
BMD associated with free and bioavailable vitamin D – March 2011 06 Jan, 2014
Low vitamin D, not low BMD, associated with both breaking hip and upper body bone in a fall – Oct 2013 05 Nov, 2013
Acute Multiple Sclerosis relapse associated with low bone mineral density (low vitamin D) – Oct 2013 12 Oct, 2013
Vitamin K2 from natto improved bone mineral density – March 2011 11 Oct, 2013
Working other than dayshift reduces vitamin D levels and Bone Mineral Density and increases bone pain – Aug 2013 22 Aug, 2013
Low vitamin D associated with 5.5X increased risk of low bone mineral density – March 2013 22 Aug, 2013
Hypothesis: Not vitamin D deficient if have normal PTH and BMD – May 2013 01 Jun, 2013
Vitamin D did not increase BMD among some ballet dancers – March 2012 28 Mar, 2012
9 minutes a day of sun improved BMD Parkinsons disease patients – Jan 2011 01 Jun, 2011
Reduced vitamin D and BMD and Neurological Conditions – April 2011 05 May, 2011
BMD improved with 800 mg Calcium, 400 IU of vitamin D, and 100 ug of vitamin K – April 2011 04 Apr, 2011
Low BMD among teaching doctors in India - July 2010 09 Jul, 2010

Meta-analysis of Vitamin D and Bone Mineral Density - April 2023

Effect of supplemental vitamin D3 on bone mineral density: a systematic review and meta-analysis
Nutr Rev . 2023 Apr 11;81(5):511-530. doi: 10.1093/nutrit/nuac068 behind publisher paywall
Elham Kazemian 1, Ali Pourali 2, Fatemeh Sedaghat 3, Mehrdad Karimi 4, Vahid Basirat 5, Zohreh Sajadi Hezaveh 6 7, Sayed Hossein Davoodi 7, Michael F Holick 8

Context: There is still controversy over the effect of vitamin D3 supplementation on bone health.

Objective: The effects of vitamin D3 supplementation on bone mineral density (BMD) and markers of bone turnover, as well as the dose-response relationship between vitamin D3 and bone health in adults, were evaluated.

Data sources: The PubMed, Scopus, Cochrane, Web of Science, and AGRIS databases were searched for articles published through April 30, 2022. Thirty-nine of the 6409 records identified met the inclusion criteria.

Data extraction: Data were extracted from articles by 2 authors, and data extraction was cross-checked independently. A random-effects model was used to estimate the pooled effect size and the associated 95%CI for the effect of vitamin D3 for each outcome. A one-stage random-effects dose-response model was used to estimate the dose-response relationship between vitamin D3 supplementation and BMD.

Data analysis: Results of meta-analysis showed a beneficial effect of vitamin D3 at the

  • lumbar spine (standardized mean difference [SMD] = 0.06; 95%CI, 0.01-0.12) and
  • femoral neck (SMD = 0.25; 95%CI, 0.09-0.41).

Dose-response analysis revealed a linear relationship between vitamin D3 supplementation doses and

  • BMD at the femoral neck,
  • lumbar spine, and
  • total hip sites.

No significant effect of vitamin D3 supplementation on whole-body or total hip BMD was observed (P > 0.05). Vitamin D3 supplementation significantly decreased BMD at both proximal and distal forearm (SMD = -0.16; 95%CI, -0.26 to -0.06). The variables of ethnicity, age, baseline 25-hydroxyvitamin D (25[OH]D), menopause status, vitamin D3 dosing frequency, and bone health status (P interaction = 0.02) altered the effect of vitamin D3 supplementation on BMD. Additionally, a nonlinear relationship between vitamin D3 supplement doses and markers of bone turnover was found.

Conclusion: A protective effect of vitamin D3 supplementation on BMD of the lumbar spine, femoral neck, and total hip is implicated.

VitaminDWiki – Bone - Health category contains

300 items in Bone - Health category
See also

VitaminDWiki – Overview Osteoporosis and vitamin D contains

  • FACT: Bones need Calcium (this has been known for a very long time)
  • FACT: Vitamin D improves Calcium bioavailability (3X ?)
  • FACT: Should not take > 750 mg of Calcium if taking lots of vitamin D (Calcium becomes too bio-available)
  • FACT: Adding vitamin D via Sun, UV, or supplements increased vitamin D in the blood
  • FACT: Vitamin D supplements are very low cost
  • FACT: Many trials, studies. reviews, and meta-analysis agree: adding vitamin D reduces osteoporosis
  • FACT: Toxic level of vitamin D is about 4X higher than the amount needed to reduce osteoporosis
  • FACT: Co-factors help build bones.
  • FACT: Vitamin D Receptor can restrict Vitamin D from getting to many tissues, such as bones
  • It appears that to TREAT Osteoporosis:
  •        Calcium OR vitamin D is ok
  •        Calcium + vitamin D is good
  •        Calcium + vitamin D + other co-factors is great
  •        Low-cost Vitamin D Receptor activators sometimes may be helpful
  • CONCLUSION: To PREVENT many diseases, including Osteoporosis, as well as TREAT Osteoporosis
  • Category Osteoporosis has 209 items
  • Category Bone Health has 300 items

Note: Osteoporosis causes bones to become fragile and prone to fracture
  Osteoarthritis is a disease where damage occurs to the joints at the end of the bones

VitaminDWiki - 31 studies in both categories Bone AND Osteoporosis

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19778 BMD vit D.jpg admin 09 Jul, 2023 23:31 18.80 Kb 127