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Depression Overview

254 items in Depression category
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    • (More Depression info below)

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If you have a disease associated with low Vit D take Vit D
Raising your Vit D levels will substantially prevent other low-Vit D health problems
Proof that Vitamin D Works   Getting Vitamin D into your body

Is 50ng enough?   How to restore levels quickly  VitaminDWiki interview and transcript - Jan 2022
Books and Videos 241   Diseases that may be related via low vitamin D
Reasons for low response to vitamin D   Why are doctors reluctant
Cancer studies include:   Breast 248   Colon 138   Lung 54   Prostate 97   Pancreatic 55   Skin 119
Colds and flu   Dark Skin 458   Diabetes 529   Obesity 409   Pregnancy 860   Seniors 406
COVID-19 treated by Vitamin D - studies, reports, videos

See also in VitaminDWiki

Analysis of 33 meta-analyses found Omega-3 to be the best way to improve mental health - 2018

The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta-review of meta-analyses of randomized controlled trials
FREE PDF Described at GrassrootsHealth
VitaminDWiki Mental disorders fought by Omega-3 etc. - meta-meta-analysis Oct 2019

12+ Anxiety studies in VitaminDWiki

8 VitaminDWiki pages with ANXIETY in title
This list is automatically updated

Items found: 12

Screening proposed for Anxiety Disorders in all US Adults - June 2023

Screening for Anxiety Disorders in Adults - US Preventive Services Task Force Recommendation Statement
J. American Medical Association doi:10.1001/jama.2023.9301  Download the PDF from VitaminDWiki

  • For all adults aged 19 - 65
  • Lifetime prevalence of anxiety disorders in (US) adults was 26 % for men and 40 % for women (as of 2002)
  • Anxiety and depressive disorders often overlap. One cohort study found that 67% of individuals with a depressive disorder also had a current anxiety disorder, and 75% had a lifetime comorbid anxiety disorder


Why not just improve health and reduce anxiety in everyone with vitamin D and/or Omega-3

37% of Americans take drugs that list depression as a possible side effect - July 2023

Common medications raise depression risk, NEW study warns

  • Depression With Drugs - Are Your Medications Making You Depressed? May 2023

Vitamin D reduces depression (4,000+ IU daily for 8+ weeks) - meta-analysis May 2020

The effect of vitamin D supplement on negative emotions: A systematic review and meta-analysis
Depression and Anxiety May 2020 https://doi.org/10.1002/da.23025 PDF is behind $15 pawall
Ying-Chih Cheng, Yu-Chen Huang, Wei-Lieh Huang

The several meta-analyses of the effect of vitamin D on depression have produced inconsistent results and studies dealing with anxiety were not incorporated. There has been no comprehensive analysis of how results are affected by the nature of the sample or the dosage and duration of supplementation. The study is aimed to investigate whether vitamin D supplementation reduces negative emotions and to analyze the possible influence of sample and regimen.

We conducted a systematic review and meta-analysis of randomized controlled trials comparing the effect of vitamin D and placebo on negative emotion. Databases were searched for relevant articles published before February 2019.

The analysis covered 25 trials with a total of 7,534 participants and revealed an effect of vitamin D on negative emotion (Hedges' g = −0.4990, 95% CI [−0.8453, −0.1528], p = .0047, I2 = 97.7%). Subgroup analysis showed that vitamin D had an effect on patients with major depressive disorder and on subjects with serum 25(OH)D levels ≤50 nmol/L. The pooled data from trials of vitamin D supplementation lasting ≥8 weeks and dosage ≤4,000 IU/day indicated that vitamin D had an effect.

Our results support the hypothesis that vitamin D supplementation can reduce negative emotions. Patients with major depressive disorder and individuals with vitamin D deficiency are most likely to benefit from supplementation. But to interpret the results with high heterogeneity should still be cautious.

Depression decreased by 300,000 IU injection of Vitamin D - RCT Oct 2020

Effect of adjunctive single dose parenteral Vitamin D supplementation in major depressive disorder with concurrent vitamin D deficiency: A double-blind randomized placebo-controlled trial
J. of Psychiatric Research Vol 129, Oct 2020, Pages 250-256 https://doi.org/10.1016/j.jpsychires.2020.07.037 PDF is behind a paywall
Favaz Vellekkatt a, Vikas Menon a, Medha Rajappa b, Jayaprakash Sahoo c

Adjunctive vitamin D replacement is a theoretically promising strategy to improve outcomes in major depression. Our objective was to assess the efficacy of a single parenteral dose of vitamin D supplementation at baseline as an adjunct to treatment as usual on change in depression symptom ratings (primary outcome), quality of life and clinical severity of illness (secondary outcomes) at the end of 12 weeks when compared to treatment as usual in patients with major depression and concurrent Vitamin D deficiency. Eligible participants were randomized to receive either treatment as usual (TAU; n = 23) or TAU plus single parenteral dose of 3,00,000 IU of vitamin D (n = 23) at baseline. Rater-blinded assessments of depression (primary outcome), quality of life (QoL) and clinical severity of illness were obtained at baseline, and end of follow-up (12 weeks). Intent-to-treat analyses were performed on the entire randomized sample. The intervention significantly improved depression symptom ratings, quality of life and clinical severity of illness at the end of the treatment phase. These findings indicate that a single parenteral dose (3,00,000 IU) of adjunctive vitamin D replacement at baseline is an effective and well tolerated intervention in major depressive disorder with concurrent Vitamin D deficiency. Additionally, it points to a possible role for vitamin D in the pathophysiology of depression and supports personalized approaches for treatment of major depressive disorder.

6X increase in Vitamin D and Depression studies in a decade

PubMed indicates that Depression & "Vitamin D" is becoming very popular:
Image 146 studies in 2020

Depression Vitamin D trials are being cancelled - too many were taking Vitamin D

Vitamin D depression RCT canceled: too many were taking Vitamin D supplements, etc. Feb 2018

A decade of use of antidepressive drugs doubles CVD - Oct 2022

Long-term antidepressant use tied to an increase in CVD, mortality risk MDEdge

  • " 10-year data from the UK Biobank on over 220,000 adults "
  • "The main culprits were mirtazapine, venlafaxine, duloxetine, and trazodone, although SSRIs were also tied to increased risk"

SSRIs cause long term sexual dysfunction (prescription warnings in Europe and Canada)

  • Antidepressants (SSRI) can cause 'chemical castration' June 2023
    • "In a study from 2001 involving >1000 patients with no previous history of sexual problems, 59% reported sexual dysfunction after commencing an antidepressant. For the five most commonly used drugs, 46% experienced no orgasm or ejaculation."
    • No change by the FDA, but "In June 2019, the European Medicines Agency updated the ‘Special Warnings and Precautions’ section on the label of SSRIs to warn that sexual dysfunction can persist even after treatment stops."
    • Canada also changed

Post-SSRI Sexual Dysfunction

  • "Close to 100% of people who take antidepressants experience some form of sexual side effects."
  • "Commonly used SSRIs include paroxetine (Paxil, Seroxat), fluoxetine (Prozac), sertraline (Zoloft), citalopram (Celexa), escitalopram (Lexapro), and vortioxetine (Trintellix)."
  • "The RxISK Prize of $100,000 USD is offered to anyone who can provide a cure for persistent sexual side effects after stopping antidepressants, finasteride, or isotretinoin."

Depression and Vitamin D on the web

Antidepressant drugs often not effective and hard to stop using - Oct 2022

How to make better use of antidepressants - The Economist


  • Antidepressant "drugs had a substantial effect on depression beyond that of a placebo for only 15% of patients."
  • "A study published in 2010, which examined research on two common ssris, estimated that for people with less severe depression the odds of improving by taking the drugs were just 6% higher than they were for taking a placebo. "
  • "A review of the research published on that topic, carried out in 2019, found that between 27% and 86% of people attempting to come off antidepressants experienced withdrawal symptoms, and that nearly half of them described those symptoms as severe."

 Download the PDF from VitaminDWiki

Depression on the web other than Vitamin D

Mercola and depression

  • 27% of adults are depressed or anxious] Mercola 2022 PDF
  • The Chemical Imbalance Myth and Antidepressant Harm Mercola Sept 2019
    • Peter C. Gøtzsche, a Danish physician-researcher, Gøtzsche helped found the Cochrane Collaboration in 1993
    • Wrote: "Deadly Medicines and Organized Crime: How Big Pharma Has Corrupted Healthcare - 2013
    • Wrote "Survival in an Overmedicated World: Look Up the Evidence Yourself" 2019
    • all of the 22 (depression) papers came to the conclusion that "the drugs were not beneficial in the long term."
  • Mercola 2018 Intro to Depression, with links to details has some on Vitamin D
  • Mercola June 2019
    "7% of the (US) adult population, experienced at least one major depressive episode in 2017."
    "...World Health Organization, depression is the leading cause of ill health and disability worldwide, and increased 18% between 2005 and 2015"
    "...Among seniors over the age of 65, only 14.3% met the criteria (major depressive episode)
    "Studies comparing the drugs to placebo found 20 to 40 out of 100 found relief from placebo alone, while 40 to 60 out of 100 reported improvement on an antidepressant after six to eight weeks"

VitaminDWiki - 21 studies in both categories Depression and Pregnancy

This list is automatically updated

VitaminDWiki - 29 studies in both categories Depression and Omega-3

This list is automatically updated

11+ VitaminDWiki pages with ANXIETY in title

This list is automatically updated

Items found: 12

All items in Depression category

Items associated with Depression

Omega-3 29; Top news 22; Cognitive 21; Pregnancy 20; Intervention 17; Meta-analysis 15; Magnesium 14; Diabetes 10; Seniors 10; Stroke. 9; Intervention - non daily. 8; Youth 8; etc.

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Attached files

ID Name Comment Uploaded Size Downloads
19684 Anxiety table.jpg admin 23 Jun, 2023 00:34 236.57 Kb 434
19683 Anxiety JAMA.pdf PDF 2023 admin 23 Jun, 2023 00:33 493.34 Kb 80
19012 antidepressants UK.jpg admin 22 Dec, 2022 15:16 33.38 Kb 1004
19011 How to make better use of antidepressants _ The Economist_CompressPdf.pdf PDF 2022 admin 22 Dec, 2022 03:13 3.47 Mb 172
17970 Efficacy_of_vitamin_D_in_the_treatment_of_depressi_CompressPdf.pdf admin 25 Jun, 2022 13:30 348.95 Kb 244
17969 How Vitamin D treats depression and anxiety_CompressPdf.pdf PDF 2022 admin 25 Jun, 2022 13:28 273.79 Kb 303
17494 Depression and Vitamin D - April 2022.pdf PDF 2022 admin 26 Apr, 2022 01:15 144.40 Kb 303
17464 mental-health-crisis-Mercola April 2022.pdf PDF 2022 admin 21 Apr, 2022 11:12 129.93 Kb 256
17388 Atl;antic sad teens_CompressPdf.pdf PDF 2022 admin 11 Apr, 2022 12:03 229.34 Kb 288
11023 Depression PubMed 2018.jpg admin 09 Dec, 2018 18:50 1.76 Kb 7409
9936 Depression NYT.jpg admin 09 Jun, 2018 01:27 19.66 Kb 8755
7992 Depression and Vit D studies.jpg admin 15 May, 2017 17:50 2.65 Kb 4169
5359 Depression vs other costs.jpg admin 20 Apr, 2015 02:24 36.26 Kb 4358
5107 Depression drug placebo.pdf PDF admin 01 Mar, 2015 11:15 222.32 Kb 1662
5106 Depression placebo.jpg admin 01 Mar, 2015 11:14 29.64 Kb 4955