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5,000 IU Vitamin D daily resulted in many benefits after 3 months (US soldiers) – RCT March 2019

A Prospective Cohort Study of Vitamin D Supplementation in AD Soldiers: Preliminary Findings.

Mil Med. 2019 Mar 1;184(Suppl 1):498-505. doi: 10.1093/milmed/usy393.
McCarthy MS1, Elshaw EB2, Szekely BM2, Raju D3.


Responses to constant dosing do not plateau in many people until >3 months
Study did manage to document trends at just 3 months
Probably would have had statistical significance (not just trends) if either:
- Had started with a loading dose
- Had the trial last 6 months

Average Vitamin D 23 ng ==> 35 ng
Note that 42% of the active duty soldiers were non-white,
Non-whites would likely have had low levels to start
Would have needed more than 5,000 IUs

Report of the study to the military - Aug 2019
 Download the PDF from VitaminDWiki


Many months for Vitamin D level response, and even more for the body to get the benefits

 Download the PDF from VitaminDWiki


PURPOSE: To explore response to vitamin D supplementation in active duty (AD) warfighters and translate findings into evidence-based health policy.

BACKGROUND: Soldiers are at risk for musculoskeletal injuries and metabolic dysfunction that impact physical performance and military readiness; the link with low vitamin D status is unclear.

This prospective trial enrolled 152 soldiers; baseline 25 hydroxyvitamin (OH) D level determined assignment to a no-treatment control (CG) or treatment group (TG) receiving a vitamin D3 supplement for 90 days. Symptoms, diet, sun exposure, and blood biomarkers obtained at baseline (T1) and 3 months (T2).

Cohort was predominantly white (58%) with a significant difference in racial distribution for vitamin D status. Mean (SD) 25(OH)D levels were 37.8 (5.6) ng/mL, 22.2 (5.0) ng/mL, and 22.9 (4.7) ng/mL for the CG, low dose TG, and high-dose TG at T1, respectively. Following three months of treatment, one-way ANOVA indicated a statistically significant difference between groups (F5,246 = 44.37; p < 0.0001). Vitamin D intake was 44% of Recommended Dietary Allowance throughout the first phase of the trial. Patient-Reported Outcomes Measurement Information System scores improved in TG for fatigue and sleep, p < 0.01.

CONCLUSIONS: Vitamin D deficiency is widespread in AD soldiers. Clinicians must intervene early in preventable health conditions impacting warfighter performance and readiness and recommend appropriate self-care strategies.

Created by admin. Last Modification: Sunday September 1, 2019 10:53:05 GMT-0000 by admin. (Version 13)

Attached files

ID Name Comment Uploaded Size Downloads
12566 Millitary 5000 IU.pdf admin 01 Sep, 2019 744.03 Kb 635
12565 3 month military.jpg admin 01 Sep, 2019 54.65 Kb 546
12338 RCT improvement.jpg admin 16 Jul, 2019 34.61 Kb 550
12336 Soldier RCT 5,000 IU.pdf admin 16 Jul, 2019 143.70 Kb 651