Vitamin D and Breast Cancer - Chemoprevention or Therapy?
Vitam Miner,Volume 8 • Issue 3 • 1000184
Gruber-Bzura BM
Department of Biochemistry and Biopharmaceuticals, National Medicines Institute, Chelmska, Poland
Overview Breast Cancer and Vitamin D contains the following summary and sections
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24 Meta-analyses of Vitamin D and Breast Cancer
example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.- Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
wonder just how much more proof is needed- Breast Cancer 4X more likely if have poor genes
- Cancer - Breast category listing has
252 items along with related searches - Breast Cancer treatment – Vitamin D was the most-popular supplement – Jan 2023
- Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020
- Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019
- Vitamin D both prevents and treats Breast Cancer – 2019
- Breast Cancer 3X more likely if low vitamin D (Principal Component Analysis) – Sept 2019
- Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019
Pages listed in BOTH Breast Cancer AND Genetics
- Breast Cancer chemotherapy improved if able to suppress a vitamin D gene (CYP24A1) – May 2023
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Many Ashkenazi Jewish diseases associated with low vitamin D or poor Vit D genes
- Breast Cancer far more likely in the sister having poor Vitamin D binding protein or poor CYP2R1 gene – March 2018
- Breast Cancer rate reduced 72 percent by vitamin D gene polymorphism CYP24A1 – Nov 2014
- Genes may account for some of AA Breast Cancer – April 2012
- Breast cancer and Vitamin D receptors, CP27B1, and CYP24A1 – Sept 2010
- Genes breast cancer and vitamin D receptor - Sept 2010
Pages listed in BOTH Breast Cancer AND Vitamin D Receptor- An activated Vitamin D Receptor fights Autoimmune Diseases, Infections, Cancers, etc. – Dec 2023
- Breast Cancer risk reduced if consume butyrate - Dec 2023
- Breast cancer spreads to bone if poor vitamin D Receptor (no surprise) – Oct 2022
- Some breast cancers may be treated RNA changes caused by Vitamin D – March 2022
- Breast Cancer, Vitamin D, and genes – Welsh Nov 2021
- After lactation Vitamin D levels are low, increased risk of Breast Cancer, vitamin D should decrease risk – Aug 2021
- Breasts process Vitamin D and change gene activation, might prevent breast cancer if given more Vit. D – July 2021
- Breast cancer associated with Vitamin D Receptor (14th study) – Oct 2019
- After breast cancer treatment 4,000 IU of Vitamin D was not enough to help if have poor Vitamin D receptor – June 2019
- Breast Cancer death 1.8 X more likely if poor Vitamin D Receptor – April 2019
- Breast Cancer and Vitamin D review – March 2018
- Women with Breast Cancer were 16.9 times more likely to have a poor Vitamin D Receptor – Jan 2019
- Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018
- Two chemicals increase the Vitamin D receptor and decrease the growth of breast cancer cells in the lab - March 2018
- Breast Cancer reduces receptor and thus blocks Vitamin D to the cells – several studies
- Vitamin D receptor as a target for breast cancer therapy (abstract only) – Feb 2017
- Breast Cancer was 4.6 times more likely if have a poor Vitamin D Receptor – Dec 2016
- Increased Breast Cancer metastasis if low vitamin D or poor VDR – Feb 2016
- Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015
- Vitamin D receptor in breasts and breast cancer vary with race – March 2013
- Breast Cancer incidence change by 40 percent with vitamin D receptor genes – Oct 2012
- Genes breast cancer and vitamin D receptor - Sept 2010
Cofactors also prevent Breast Cancer- Low Magnesium results in poor health (Breast Cancer in this case) – Nov 2019
- Breast Cancer reduced 20 percent by fish (Omega-3) – meta-analysis Feb 2019
- Breast Cancer rate reduced by 40 percent with Omega-3 – meta-analysis June 2013
Chemotherapy and Breast Cancer
- Chemotherapy drugs often reduce Vitamin D levels, restoring levels helps– Aug 2018
- Breast Cancer chemotherapy 2.7 X more likely to be successful if not vitamin D deficient – Dec 2017
- Breast Cancer Chemotherapy dropped Vitamin D levels by 6 nanograms – Nov 2015
- Chemotherapy might be augmented with Vitamin D – Jan 2017
- Vitamin D levels dropped 3 ng during cancer chemotherapy – May 2012
- Chemotherapy might be amplified by vitamin D has the following chart and lots of details
Download the PDF from VitaminDWiki
Most evidence studies have concluded that there is an inverse association between blood levels of calcidiol and cancer incidence and survival. These findings especially apply in colorectal and breast cancer (BC). The phenomenon of the multidirectional activity of vitamin D is possibly due to the presence of the vitamin D receptor (VDR) in most non-skeletal human cells including cancer cells. The crucial is that a wide range of the genes regulated by VDR are related with cell proliferation, differentiation, angiogenesis and metastasis. The aim of this paper was to present recent data on the possible role of vitamin D as an chemopreventive or therapeutic agent against BC through considering the anticancer mechanisms induced by this vitamin as well as presenting the results of clinical studies on the impact of vitamin D status on BC incidence, survival and response to therapy. This review is based on an electronic search of articles in the PubMed database, including papers published mostly within last five years in that field and selected according to the following criteria: well commented studies concerning the association between vitamin D status and BC risk, response to therapy or survival, with the vitamin D supplementation outline and statistical data.
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