Changes in CYP3A4 gene affects Vitamin D, health, reactions to some drugs, etc - June 2022

Interplay of Vitamin D and CYP3A4 Polymorphisms in Endocrine Disorders and Cancer

Endocrinol Metab (Seoul). 2022 Jun 3. doi: 10.3803/EnM.2021.1349
Siva Swapna Kasarla 1, Vannuruswamy Garikapati 2, Yashwant Kumar 1, Sujatha Dodoala 3

Chart of Vitamin D interactions

CYP3A4 at VDW13631

Chart of CYP3A4 and Vitamin D

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Chart of Vitamin D and Calcium

Vit D And Calcium @ VDW13631

Chart of Vitamin D and Cancer

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Chart of Vitamin D and Immune System

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Table of CYP3A4 interactions

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Vitamin D has received considerable optimistic attention as a potentially important factor in many pathological states over the past few decades. However, the proportion of the active form of vitamin D metabolites responsible for biological activity is highly questionable in disease states due to flexible alterations in the enzymes responsible for their metabolism. For instance, CYP3A4 plays a crucial role in the biotransformation of vitamin D and other drug substances. Food-drug and/or drug-drug interactions, the disease state, genetic polymorphism, age, sex, diet, and environmental factors all influence CYP3A4 activity. Genetic polymorphisms in CYP450-encoding genes have received considerable attention in the past few decades due to their extensive impact on the pharmacokinetic and dynamic properties of drugs and endogenous substances. In this review, we focused on CYP3A4 polymorphisms and their interplay with vitamin D metabolism and summarized the role of vitamin D in

  • calcium homeostasis,
  • bone diseases,
  • diabetes,
  • cancer,
  • other diseases, and
  • drug substances.

We also reviewed clinical observations pertaining to CYP3A4 polymorphisms among the aforementioned disease conditions. In addition, we highlighted the future perspectives of studying the pharmacogenetics of CYP3A4, which may have potential clinical significance for developing novel diagnostic genetic markers that will ascertain disease risk and progression.

PDF Table of Contents

Vitamin D overview
Vitamin D bioconversion
Skin
Liver
Kidney
Role of CYP3A4 in the inactivation of vitamin D
Clinical relevance of CYP3A4 enzymatic studies
VITAMIN D AND ITS PHYSIOLOGICAL ROLE
Calcium homeostasis
Skeletal homeostasis
Immunomodulation
Cancer
Other disease conditions and drugs
CONCLUSIONS
 Download the PDF from VitaminDWiki

VitaminDWiki - Genetics chart shows the vitamin D genes, including CYP3A4

in Visio for 2023

3+ VitaminDWiki pages have CYP3A4 in the title

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Items found: 3

VitaminDWiki - 6 studies in both categories Genetics and Immune System

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29+ VitaminDWiki Genetics pages have CANCER in the title

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Items found: 32
Title Modified
Cervical Cancer is prevented by Vitamin D, and treated if caught early (genes are important) – May 2023 27 May, 2023
Breast Cancer chemotherapy improved if able to suppress a vitamin D gene (CYP24A1) – May 2023 18 Mar, 2023
Colon Cancer protects itself by changing the VDR and CYP3A4 genes – Dec 2022 06 Dec, 2022
Lung Cancer is up to 7 X more deadly if poor vitamin D genes – Oct 2021 25 Oct, 2021
Fight Cancer with more than cut, burn, and poison – Nobel prize for T-Cell – Oct 2018 12 Aug, 2021
3X higher risk of oral cancer if CYP27B1 and CYP24A1 genes were different – May 2012 22 Jan, 2021
Oral Cancers - increased risk if low vitamin D or poor vitamin D genes 22 Jan, 2021
Epigenetics identified Cervical Cancer 100 percent of time – 2019 23 Dec, 2019
Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019 15 Nov, 2019
Lung Cancer (NSLC) more lethal if poor Vitamin D gene ( CYP2R1) – Oct 2019 17 Oct, 2019
Colorectal Cancer risk increases when genes reduce the vitamin D levels – Aug 2019 23 Aug, 2019
Thyroid Cancer 1.9 X more likely if poor gene to generate Vitamin D from the sun (DHCR7) – July 2019 31 Jul, 2019
CYP24A1 gene in cancer cells may actually remove vitamin D from the blood – Oct 2012 16 May, 2019
Cancer treatment by Vitamin D sometimes is restricted by genes – Oct 2018 01 Nov, 2018
The Anti-cancer Actions of Vitamin D – Jan 2013 29 Jun, 2018
Live longer with lung cancer if have good vitamin D genes (or perhaps lots of vitamin D) – Dec 2017 17 Jun, 2018
Breast Cancer far more likely in the sister having poor Vitamin D binding protein or poor CYP2R1 gene – March 2018 18 Mar, 2018
Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014 25 Jul, 2017
How Vitamin D prevents many cancers (c-MYC) – Nov 2012 27 Jan, 2017
Breast Cancer rate reduced 72 percent by vitamin D gene polymorphism CYP24A1 – Nov 2014 30 Mar, 2016
Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1 – Nov 2015 16 Nov, 2015
Prostate Cancer – Vitamin D – CYP27B1 – CYP24 – June 2011 16 Nov, 2015
Breast cancer and Vitamin D receptors, CP27B1, and CYP24A1 – Sept 2010 26 Nov, 2014
Colorectal cancer – need more vitamin D if you have certain genes – Aug 2013 22 May, 2014
Colon cancer more likely in blacks due to differences in Vitamin D genes (wonder if more Vitamin D would help) – May 2014 21 May, 2014
Pancreatic Cancer association with PRKCA gene and the active form of vitamin D – Nov 2012 10 Aug, 2013
Epigenetics of prostate cancer and vitamin D – June 2010 09 Jul, 2013
Genes breast cancer and vitamin D receptor - Sept 2010 08 Jul, 2013
Genes may account for some of AA Breast Cancer – April 2012 08 Jul, 2013
600 mg of Calcium and a gene increases probability of Prostate Cancer by 50 pcnt – Nov 2012 07 Jul, 2013
Unsure of association of vitamin D and prostate Cancer - 2011 21 Jan, 2013
Gene variations were not associated with risk of colorectal cancer in Czech – June 2010 02 Jul, 2010
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