Personalized treatment of Vitamin D

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23+ Personalization factors for Vitamin D treatment:

1. Body size: less for youths, more for obese
2. Have genes that reduce Vitamin D blood level (which can be measured)
3. Have genes that restrict the amount getting to cells
   Measurement of PTH may be a proxy for Vitamin D level in cells
   One of the genes, that deactivates the Vitamin D Receptor, can be activated 16+ ways
4. Have a disease associated with Low Vitamin D
5. Have a disease that consumes a lot of Vitamin D
6. Have a disease that is associated with poor Vitamin D response ( Asthma, etc.)
7. Have a disease that can only be fought by |high levels of Vitamin D (such as MS, psoriasis)
8. Have a disease that deactivates the Vitamin D Receptor (COVID, Breast Cancer, etc)
9. Have a poor gut – which decreases bio-absorption of Vitamin D (May need a gut-friendly form)
10. Have had gallbladder removed – which decreases absorption of fat-soluble Vitamins
11. Smoking
12. Taking drugs that reduce Vitamin D
13. Having a medical procedure that decreases Vitamin D level (Dialysis, surgery, etc.)
14. Have a disease that is associated with low Vitamin D (Diabetes, etc.)
15. Have a disease that is associated with a poor Vitamin D response (Asthma, etc.)
16. Unable to or dislikes swallowing pills (powder, liquid, spray, and topical forms are available)
17. Was born preterm or mother had low vitamin D while pregnant
    increases the risk of many Vitamin D diseases up to 50 years later
18. Have diseases that run in the family that are associated with low Vitamin D
19. Have little ability to get Vitamin D from the noonday sun
    Concealing clothes, far from the equator, dark skin, avoiding the very hot sun, shift worker, nursing home, wheelchair
20. Are in a very stressful situation
21. Have poor liver or kidney (needed to metabolize vitamin D in the bloodstream)
22. Have a poor lymph system (required to get Vitamin D in the intestine into the blood)
23. Loading dose if signs of improvement are needed in a month instead of within a fraction of a year

The above are all documented in VitaminDWiki - Solutions include:
different dose size, different form, UV lamp, cofactors, non-daily dose

Hope to have an interactive service on VitaminDWiki before the end of 2024 which will allow visitors to quickly and easily get personalized Vitamin D recommendations

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VitaminDWiki – Vitamin D: not one size, type, form, route for all - Jan 2022

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VitaminDWiki – Increased Vitamin D response if take cofactors, etc

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VitaminDWiki – Reasons for low response to vitamin D

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VitaminDWiki – PTH and Vitamin D - many studies

PTH bottoming out shows that Vitamin D got to cells: not restricted by 5 genes nor Magnesium

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VitaminDWiki – How you might double your response to vitamin D

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Personalized dosing: 70 to 1 differences in doses for vitamin D treatment of Breast Cancer

Lots of Vitamin D needed weekly during Breast Cancer Treatment (mean 20,000 IU up to 140,000 IU) – March 2024

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VitaminDWiki – Forms of Vitamin D category has 108 items

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The Power of Vitamin D: Is the Future in Precision Nutrition through Personalized Supplementation Plans? - April 2024

Nutrients 2024, 16(8), 1176; https://doi.org/10.3390/nu16081176
by Mladen Mavar 1,Tamara Sorić 1,*,Ena Bagarić 2,Ana Sarić 3 andMarijana Matek Sarić 4ORCID
1 Psychiatric Hospital Ugljan, Otočkih Dragovoljaca 42, 23275 Ugljan, Croatia
2 Almagea Ltd., Ulica Julija Knifera 4, 10020 Zagreb, Croatia
3 School of Medicine, Catholic University of Croatia, Ilica 242, 10000 Zagreb, Croatia
4 Department of Health Studies, University of Zadar, Splitska 1, 23000 Zadar, Croatia

In the last few decades, vitamin D has undeniably been one of the most studied nutrients. Despite our ability to produce vitamin D through sunlight exposure, its presence in several natural food sources and fortified foods, and its widespread availability as a dietary supplement, vitamin D deficiency is a serious public health problem, affecting nearly 50% of the global population. Low serum levels of vitamin D are being associated with increased susceptibility to numerous health conditions, including respiratory infections, mental health, autoimmune diseases, and different cancer types. Although the association between vitamin D status and health is well-established, the exact beneficial effects of vitamin D are still inconclusive and indefinite, especially when considering the prevention and treatment of different health conditions and the determination of an appropriate dosage to exert those beneficial effects in various population groups. Therefore, further research is needed. With constant improvements in our understanding of individual variations in vitamin D metabolism and requirements, in the future, precision nutrition and personalized supplementation plans could prove beneficial.

Clipped from PDF
Dose considering age and BMI = ‘Dose in IU = [(8.52—desired change in 25(OH)D) + (0.07 × age) – (0.20 × body mass index) + (1.74 × serum albumin) – (0.62 × starting 25[[OH]D concentration)]/(−0.002)’
 Download the PDF from VitaminDWiki

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Study appears to deal with only 3 of the above 20+ concerns

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78. Li, G.; Mbuagbaw, L.; Samaan, Z.; Falavigna, M.; Zhang, S.; Adachi, J.D.; Cheng, J.; Papaioannou, A.; Thabane, L. Efficacy of Vitamin D Supplementation in Depression in Adults: A Systematic Review. J. Clin. Endocrinol. Metab. 2014, 99, 757-767. https://doi.org/10.1210/jc.2013-3450.
79. Shaffer, J.A.; Edmondson, D.; Wasson, L.T.; Falzon, L.; Homma, K.; Ezeokoli, N.; Li, P.; Davidson, K.W. Vitamin D supplemen­tation for depressive symptoms: A systematic review and meta-analysis of randomized controlled trials. Psychosom. Med. 2014, 76, 190-196. https://doi.org/10.1097/psy.0000000000000044.
80. Spedding, S. Vitamin D and depression: A systematic review and meta-analysis comparing studies with and without biological flaws. Nutrients 2014, 6, 1501-1518. https://doi.org/10.3390/nu6041501.
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Factors to take into account when interpreting 25-hydroxy-vitamin D serum levels – March 2024

Acta Clin Belg. 2024 Mar 7:1-6. doi: 10.1080/17843286.2024.2327218 – PDF behind paywall
Joris R Delanghe 1, Marijn M Speeckaert 2 3, Thomas Maenhout 1

Background: Assessing vitamin D status, typically evaluated using serum or plasma 25-hydroxy vitamin D [25(OH)D] concentration, is complex because of various influencing factors.

Methods: Seasonality significantly affects intra-individual variability in 25(OH)D levels. This variation can be addressed by employing cosinor functions that are tailored to the geographical location of the patient to correct for seasonal effects. In addition to seasonality, genetic factors, such as DBP polymorphism and body composition, particularly adiposity, play crucial roles. Dialysis patients with DBP 2-2 phenotype exhibit higher vitamin D requirements. Genotyping/phenotyping of DBP allows for better tailored vitamin D supplementation. The lipid-soluble nature of vitamin D also interacts with plasma components such as serum triglycerides, which can influence vitamin D measurements. Adiposity, which is negatively correlated with vitamin D concentration, necessitates body mass-based mathematical adjustments for accurate vitamin D assessment in subjects with extreme BMI values.

Conclusions: Accordingly, vitamin D replacement therapy must be personalized, taking into account factors such as body size and seasonal variations, to effectively reach the target serum 25(OH)D concentrations.

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Perhaps 100X difference in BLOOD-Level responses to identical Vitamin D dosing

Worst response
Worst form of vitamin D (oil-based and the person does not digest oils well)
Poor genes
Poor gut
Smoker
Asthmatic, COPD
Not taken with the largest meal of the day (thus less time in gut for absorption
Best Response
Water-based vitamin D
Also have adequate co-factors: Magnesium, Omega-3, and Boron etc
Have good genes or use a form that by-passes a poor gene

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Perhaps a 500X difference in CELL-Level responses to identical Vitamin D dosing

the following genes have been proven to restrict Vitamin D in blood from getting to cells
CYP3A4, CYP27B1, CYP24A1, Vitamin D Receptor, Vitamin D Binding Protein
There are many ways to bypass each of those restrictions
See Genetics for details

• At the suggestion of VitaminDWiki, it is now possible to measure Vitamin D at the cell-level
  But at $200 and with no data on the results
  , virtually no one buys the test