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Overview Fibromyalgia or Chronic Fatigue and vitamin D

Did you know?
  • Large doses of vitamin D reduced CFS/Fibromyalgia in > 10 studies
  • Many books and online forums recommend vitamin D for CFS/Fibromyalgia
  • Vitamin D also reduces a wide variety of pains
          (More Fibromyalgia/CFS info below)

Learn how Vitamin D is essential for good health
  Watch a 5 minute video "Does Less Sun Mean more Disease?"
  Browse for other Health Problems and D in left column or here
  see also Supplementing and More in the menu at the top of every page
If you have a disease associated with low Vit D take Vit D
Raising your Vit D levels will substantially prevent other low-Vit D health problems
Proof that Vitamin D Works   Getting Vitamin D into your body

Is 50ng enough?   How to restore levels quickly  VitaminDWiki interview and transcript - Jan 2022
Books and Videos 231   Diseases that are related via low vitamin D
Reasons for low response to vitamin D   Why are doctors reluctant
Cancer studies include:   Breast 241   Colon 134   Lung 53   Prostate 97   Pancreatic 54   Skin 116
Colds and flu   Dark Skin 455   Diabetes 517   Obesity 398   Pregnancy 838   Seniors 389
COVID-19 treated by Vitamin D - studies, reports, videos
  • Vitamin D Levels can be restored quickly within a week with a loading dose.
    • With a loading dose you will probably feel the benefits in a week.
  • A Vitamin D test is generally NOT required before having a loading dose.
  • If you don't feel better within 2 weeks you do not need to continue taking vitamin D for CFS/ME/Fibromyalgia.
       When stopped, your body will naturally reduce eliminate any excess vitamin D within 2 months.

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Source of above chart = Medscape
FibroGuide - easy introduction to Fibromyalgia featured on MedScape
Fibromyalgia is the second most common condition affecting your bones and muscles. WebMd 2017
huge resource, nothing about Vitamin D

Chronic Fatigue Syndrome and long-haul COVID-19


See also VitaminDWiki - Fatigue


See also VitaminDWiki - Fibromyalgia


54+ VitaminDWiki pages with FIBROMYALGIA OR FATIGUE in the title

This list is automatically updated

Items found: 54
Title Modified
Long-COVID fatigue reduced by Vitamin C and l-Arginine in one month– RCT Nov 2022 24 Nov, 2022
Fatigue and other long-haul problems appear to be associated with low Magnesium - Chambers Oct 2022 30 Oct, 2022
Coronary Artery Disease Chest Pain, Anxiety, and Fatigue associated with low vitamin D – Oct 2022 07 Oct, 2022
Chronic Fatigue Syndrome and long-haul COVID-19 26 Sep, 2022
Fibromyalgia Syndrome correlated with poor Vitamin D Receptor (less D to cells) in a small study – July 2022 24 Aug, 2022
Fibromyalgia and Musculoskeletal Pain treated by raised Vitamin D levels – July 2022 23 Jul, 2022
Overview Fibromyalgia or Chronic Fatigue and vitamin D 22 May, 2022
Epstein Barr Virus and Chronic Fatigue Syndrome 13 Dec, 2021
Post-stroke fatigue cut in half by Vitamin D (just 600 IU daily in 3 months) – Nov 2021 22 Nov, 2021
Severe fatigue and headache in 4 pct of vaccinated, age 16-25 - Oct 2021 27 Oct, 2021
Adverse reactions to 100 Pfizer booster vaccinations: 83 pain, 63 fatigue, 48 headache, etc. - Sept 2021 13 Oct, 2021
PMS fatigue 2.5X more likely if poor vitamin D Receptor – Sept 2021 23 Sep, 2021
Long-haul fatigue, etc. common after viral infections (SARS1,2, MERS, Swine, 1918,...) 21 Feb, 2021
Fatigued seniors have lower levels of Vitamin D – Oct 2019 20 Oct, 2019
Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019 19 Oct, 2019
8 Signs of Low Vitamin D - sweating, bones ache, muscle pain, poor immune, fatigue, slow healing etc. – YouTube Dec 2018 05 Aug, 2019
Fibromyalgia severity associated with serotonin but not Vitamin D (almost all were insufficient) – May 2019 27 May, 2019
Fibromyalgia associated with low vitamin D, more studies needed – review Dec 2018 15 Oct, 2018
PMS: 1.5X more likely to have cramps, feel fatigued and anxious if low vitamin D – Sept 2018 03 Sep, 2018
Muscle fatigue 4X less likely in rugby players getting Omega-3 and protein – July 2018 14 Jul, 2018
Fibromyalgia pain substantially reduced by weekly Vitamin D (50,000 IU) – June 2018 23 Jun, 2018
Chronic Fatigue Syndrome reduced by D-Ribose – 2012 07 May, 2018
Fibromyalgia associated with lower Vitamin D – meta-analysis Oct 2017 10 Feb, 2018
Fibromyalgia benefits from transdermal magnesium chloride – Sept 2015 09 Aug, 2017
Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – Nov 2016 27 Jun, 2017
Fatigue reduced by a single dose of vitamin D (100,000 IU) – RCT Dec 2016 27 Feb, 2017
Fibromyalgia helped by Vitamin D – still not sure how much, and why - June 2016 31 Dec, 2016
Juvenile Lupus fatigue reduced by vitamin D ( 50,000 IU weekly for 6 months) – RCT May 2015 24 Nov, 2016
Hypothesis – Fatigue the day after sex is due to deficiency of Vitamin D, Magnesium, and Zinc 10 Oct, 2016
Sleep, Vitamin D, Vitamin B-12, IBS, Fibromyalgia - Gominak March 2015 27 Jul, 2016
Hypothesis – Fatigue the day after sex is due to deficiency of vitamin D or Magnesium 25 Jan, 2016
Fibromyalgia development 1.9 X more likely if low vitamin D – Jan 2016 20 Jan, 2016
Fibromyalgia pain reduced with vitamin D intervention that achieved 30-48 ng – RCT Feb 2014 05 Nov, 2015
2000 IU of vitamin D reduced fatigue of advanced cancer – RCT May 2012 03 Sep, 2015
Less fatigue if more vitamin D (90 percent of palliative cancer were deficient) – Aug 2015 03 Sep, 2015
Chicago Sun Times on vitamin D: Depression, chest pain, fibromyalgia, Holick, 3000 IU without test - May 2010 15 Jul, 2015
Chicago Times on vitamin D: Depression, chest pain, fibromyalgia, Holick, 3000 IU without test - May 2010 15 Jul, 2015
High dose vitamin reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis - July 2015 11 Jul, 2015
Overlap between Fibromyalgia and other Chronic Pains – 2012 11 Jan, 2015
Fatigue substantially reduced by 450,000 IU Vitamin D2 spread over 5 weeks – Aug 2014 06 Jan, 2015
Fibromyalgia pain with trazodone reduced by 50 percent with weekly 50,000 IU of vitamin D – RCT Nov 2014 22 Nov, 2014
Rheumatoid arthritis associated with low vitamin D – Fibromyalgia makes it even lower – Oct 2014 08 Oct, 2014
Muscle fatigue reduced with 10,000 IU of vitamin D – March 2013 05 May, 2014
7100 IU vitamin D (50,000 weekly) significantly reduced fibromyalgia – 2009 20 Jan, 2014
Chronic Fatigue and Vitamin D insight – Jan 2014 12 Jan, 2014
Vitamin D at CureTogether: Fibromyalgia, MS, Psorasis, etc - Dec 2013 26 Dec, 2013
Literature review of Fibromyalgia and vitamin D – Sept 2011 18 Dec, 2013
Fibromyalgia patients with low vitamin D have more pain – Dec 2013 18 Dec, 2013
Chronic Fatigue Syndrome reduced with 25,000 IU of vitamin D weekly – June 2013 22 Nov, 2013
No rise in vitamin D levels of fibromyalgia patients in the summer – Sept 2013 08 Sep, 2013
Hypothesis – vitamin D will decrease chronic inflammation and fatigue – Oct 2010 13 Jul, 2013
20000 IU vitamin D and MS – less fatigue and relapse Dec 2010 22 Feb, 2012
If less than 20 ng then 2X more likely to be fatigued after brain injury - April 2010 05 Nov, 2011
Taking vitamin D reduced Lupus fatigue– Aug 2010 03 Sep, 2010

Fibromyalgia treated with 50,000 IU Vitamin D weekly and rehab therapy for 6 months – June 2022

Can the Combination of Rehabilitation and Vitamin D Supplementation Improve Fibromyalgia Symptoms at All Ages?
J Funct Morphol Kinesiol. 2022 Jun 20;7(2):51. doi: 10.3390/jfmk7020051.
Dalila Scaturro 1, Fabio Vitagliani 2, Sofia Tomasello 3, Mirko Filippetti 4, Alessandro Picelli 4 5, Nicola Smania 4 5, Giulia Letizia Mauro 1
6 month Results (Group A <50, Group B >50)
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  • Numerical Rating Scale (NRS),
  • Fibromyalgia Impact Questionnaire (FIQ),
  • Short Form 12 Health Survey (SF-12)

Several studies have indicated a correlation between vitamin D deficiency and widespread chronic pain syndromes, such as fibromyalgia. During this study, the effect of supplementation with vitamin D in association with physical exercise in patients with fibromyalgia was evaluated, in terms of improvement of pain, functional capacity and quality of life, also evaluating the presence of any differences in age. A single-center, observational, comparative study was conducted in 80 fibromyalgia patients.
They are randomized into 2 groups:

  • Group A, consisting of patients ≤50 years; and
  • Group B, consisting of patients &>;50 years.

Both received weekly supplementation with 50,000 IU cholecalciferol for 3 months in association with a rehabilitation protocol. Patients were assessed at enrollment (T0), 3 months (T1), and 6 months (T2) from the initial assessment with blood vitamin D dosage and administration of rating scales (NRS, FIQ, and SF-12). From the comparison between the two groups, we have seen that in young people, supplementation with high-dose vitamin D improves short-term musculoskeletal pain and long-term functional capacity. Conversely, musculoskeletal pain and long-term quality of life improve in the elderly. Supplementing with high doses of vitamin D in fibromyalgia patients improves the quality of life and pain in the elderly and also the functional capacity in the young.
 Download the PDF from VitaminDWiki


11 of 12 studies found Vitamin D helped Fibromyalgia - review March 2022

Efficacy of Vitamin D Supplementation in the Improvement of Clinical Status in Patients Diagnosed with Fibromyalgia Syndrome: A Systematic Review
Curr Rheumatol Rev. 2022 Mar 7. doi: 10.2174/1573397118666220307122152 behind $95 paywall
Nanditha Venkatesan 1, Mallika Gyawali 2, Rinky A Botleroo 2, Rowan Ahmed 2, Roaa Kareem 2, Opemipo D Ogeyingbo 3, Renu Bhandari 4, Abeer O Elshaikh 2

Background Fibromyalgia syndrome is characterised by extensive muscular pain and chronic fatigue. Among the pharmacologic and other nutrient supplements that have been studied, Vitamin D has garnered attention owing to the critical role it plays in inflammatory and pain pathways. We conducted a systematic literature review to examine the efficacy of vitamin D supplementation in improving the clinical status of the patients and alleviating the symptoms of fibrom-yalgia.

Methods We searched Cochrane CENTRAL, PubMed, Science Direct, Scopus, grey literature (medrXiv and biorXiv) for observational studies, randomized controlled trials, case-control studies, and case reports published in English from January 2011 to May 2021, using the terms vitamin D and fibromyalgia or FMS. References were reviewed manually and articles were only included if they were specific in their diagnosis of fibromyalgia.
Results 2651 studies were retrieved, with 12 studies fulfilling the inclusion criteria. 11 out of these 12 studies were of high quality and showed low risk of bias. 11 of these also demonstrated definitive improvement in clinical status and various outcome measures following supplementation with Vitamin D.

Conclusions Our study emphasises an association between supplementation of vitamin D and improve-ment of the clinical condition fibromyalgia through a systematic review of high-quality studies. The study also identified areas for future scope for research that is needed for standardising the detection and treatment of this chronic condition through cost-effective supplements such as Vitamin D.


German web site and book – relief in 1 week

Response with 400,000 IU loading dose @ is.gd/7DayVitD
Case studies in book include: Back and leg pain, Chronic fatigue, Lethargy, Fatigue, Exhaustion, Neck pain, Emergency relief from exhaustion, .


4 Vitamin D books with sections on Chronic Pain/ Fibromyalgia

  • The Vitamin D Solution: CFS on pages 4,12,67 Fibromyalgia 4, 6, 12, 65-68
  • The Vitamin D Cure: Chronic pain and Fibromyalgia pg 133-136
  • Power of Vitamin D: contained in chapter pg 25-34 available as an e-book for $5
  • Vitamin D Prescription: Fibromyalgia on pages 4, 20-23, 80-84, 171, 185, 198-199

Loading Dose of Vitamin D

Overview Loading of vitamin D
Check that you are not allergic to vitamin D by trying a small amount - say 1,000 IU and seeing any reactions (only about 1 in 300 people are)
The brand vitamin D with the least amount of additives and no reported bad reactions is Bio-Tech - which also is the highest rated brand on Amazon
Of the few people with reactions to vitamin D, many appear to be deficient in Magnesium - Magnesium Chloride is a good supplement
A typical loading dose in 400,000 IU - can be, for example, be achieved by 50,000 IU capsules once a day for 8 days.

After loading dose just one tiny capsule every 2 weeks



Fibromyalgia worse if low vitamin D – June 2020

Association Between Low Vitamin D Levels and the Greater Impact of Fibromyalgia
J Clin Med Res. 2020 Jul;12(7):436-442. doi: 10.14740/jocmr4136
Susyane Ribeiro Beserra 1, Fabiola Isabel Suano Souza 1, Roseli Oselka Saccardo Sarni 1, Myllena Maria de Morais Pereira 2
 Download the PDF from VitaminDWiki

Background: Fibromyalgia (FM) is a clinical syndrome mainly characterized by generalized chronic pain, fatigue, sleep and cognition disorders. The role played by vitamin D in the pathophysiology of painful syndromes is poorly known. Studies assessing the association between vitamin D and FM have presented conflicting results. The aims of the current study were to assess vitamin D levels in FM patients, by comparing them to healthy controls, as well as to analyze their impact on this disease.

Methods: This was a cross-sectional study comprising 43 FM patients (ACR 2010 criteria) and 40 healthy individuals. All participants had their vitamin D levels measured, and FM patients also had their total calcium, albumin, phosphorus and parathyroid hormone (PTH) measured. Clinical variables capable of affecting the results were evaluated and the fibromyalgia impact questionnaire (FIQ) was applied.

Results: There was not statistically significant difference in global mean values of vitamin D between groups. In the total sample, only 4.8% of the individuals had vitamin D deficiency, which corresponded to the deficiency found in the group of patients; in the control, no one had vitamin deficiency; 39.8% had insufficient levels and 55.4% with sufficient levels. The mean serum vitamin D values were similar between the FM and control groups (34.8 ± 12 and 34.7 ± 12.3 ng/mL, respectively; P = 0.806). However, a significant negative correlation was found between vitamin D concentration and FIQ values, that is, patients with the greatest impact of the disease had lower concentrations of vitamin D (P = 0.018).

Conclusion: FM patients did not present higher prevalence of vitamin D deficiency or insufficiency than healthy individuals, although low vitamin D concentrations could indicate more severe disease impacts.

Clipped from PDF
“…”fibromyalgia impact questionnaire (FIQ), which comprised questions organized in 10 different items focused on investigating about participants’ functional capacity, professional status, psychological disorders and physical symptoms.”


See also pubmed - CFS, Fibromyalgia and Vitamin D

Search for (fibromyalgia OR "Chronic Fatigue") "vitamin d" 105 items as of Dec 2020


See also web - CFS, Fibromyalgia

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CDC on Fibromyalgia

  • Fibromyalgia is a disorder of unknown etiology characterized by widespread pain, abnormal pain processing, sleep disturbance, fatigue and often psychological distress.
  • People with fibromyalgia may also have other symptoms; such as:Morning stiffness, Tingling or numbness in hands and feet, Headaches, including migraines, Irritable bowel syndrome, Sleep disturbances, Cognitive problems with thinking and memory (sometimes called "fibro fog"), Painful menstrual periods and other pain syndromes
  • Fibromyalgia often co-occurs (up to 25-65%) with other rheumatic conditions such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and ankylosing spondylitis (AS).
  • Prevalence 3.4% women, 0.5% men - averaged over all ages - increases with age
  • Working age women with fibromyalgia hospitalized for occupational musculoskeletal disorders were almost 10 times less likely to return to work
    Causes and/or risk factors for fibromyalgia are unknown, but some things have been loosely associated with disease onset:
        Stressful or traumatic events, Repetitive injuries, Illness (e.g. viral infections), Certain diseases (i.e., SLE, RA, chronic fatigue syndrome), Genetic predisposition, Obesity
        Note by VitaminDWiki: most of these are associated with a decrease in vitamin D levels
  • Effect of Correction of Low Vitamin D in Fatigue Study (EViDiF Study) Aug 2014
    Full free text online. 50,000 IU of D2 3 times per week for 5 weeks got 96% of subjects > 30 ng. Total fatigue scores dropped from 33 down to 11
    same study described at Vitamin D Council free
  • A Primer on Chronic Fatigue Syndrome GreenMedInfo Jan 2015
    Mentions Vitamin D
  • Hope for Chronic Fatigue Syndrome SLATE Nov 2015
    "And the hallmark symptom of the illness is that exertion can make patients much, much worse"
    ". . . the National Institutes of Health spends $5 million to $6 million a year on a disease that affects a million Americans. (For comparison, about the same number of people with HIV/AIDS, which receives $3 billion in NIH funding.)"
    article describes major shortcommings of the previous PCE trial
  • ME isn’t just ‘exercise phobia’: it’s a physical illness Nov 2015
    People die of Myalgic Encephalomyelitis (ME) when PCE type techniquies are used.
    74 per cent of ME patients are harmed by the therapy
  • CHRONIC PAIN: WHAT IT IS AND HOW PROPER TESTING HELPS Dec 2020
    • does not mention Vitamin D

MedScape set of articles on CFS/ Fibromyalgia 2014-2015

  1. Chronic Fatigue Syndrome: Wrong Name, Real Illness Jan 2015
    Called CFS in US, and elsewhere myalgic encephalomyelitis (ME). since 1988, defined by CDC in 1999
    '' malaise lasting days to weeks following even modest physical or mental exertion, unrefreshing sleep, and cognitive dysfunction.
    Chronic pain is common and many patients also meet criteria for fibromyalgia.
    ME/CFS appears to be more common among ethnic and racial minority groups and in those of lower socioeconomic status
    Many ME/CFS patients able to pinpoint the condition's onset to a flulike illness from which they never recovered
  2. Fibromyalgia: The Latest in Diagnosis and Care Sept 2014
    It was previously called neurasthenia, then fibrositis (medical fas included removing organs to "cure" the probllem)
    diagnostic criteria, of 1990 and 2010 were meant to be used for research studies, not to diagnose individual patients.
    Now recommend looking at widespread pain accompanied by fatigue, sleep, memory, and mood problems
  3. Pain and Depression Treatment Possible in Fibromyalgia Sept 2014
  4. Chronic Fatigue Syndrome Aug 2014
  5. Fibromyalgia May 2014
    Lab testing includes:Metabolic panel, Urinalysis, Thyroid-stimulating hormone level, 25-hydroxy vitamin D level
    Vitamin B12. Iron, Magnesium, Erythrocyte sedimentation rate, Antipolymer antibodys
    See also VitaminDWiki combined Vitamin D, Iron, Magnesium deficiences
        Deficiencies of iron and vitamin D are interrelated in women
        Iron deficiency is a cause of Vitamin D deficiency which has an Iron supplement which is 23X better than typical.

Fibromyalgia description - diagnosis takes many years

Fibromyalgia - Burden of disease and disability and how it changed History by drdoc on-line
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Fibromyalgia pain worse than labor pain

Pain Medical Musing from a 1988 book
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If gut problems & Fibro - may need a different form of Vitamin D

Standard Vitamin D is not absorbed well in poorly functioning guts (IBS, etc)
There are many different "gut friendly" forms of vitamin D
Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017

Nice body chart by Dr. Carey

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EasyImmuneHealth 2014?

Fibromyalgia and Vitamin D Don't Get Misdiagnosed
Fibromyalgia and Vitamin D Deficiency very often have COMPLETELY IDENTICAL symptoms.
Large numbers of people have been misdiagnosed with Fibromyalgia when they simply have Vitamin D Deficiency- don't be one of them.
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Chronic Fatigue Syndrome associated with different gut bacteria


5 Common Causes of Chronic Fatigue - Sept 2018

5 Common Causes of Chronic Fatigue and Tests That Help Reveal The Cause Self Hacked
1) Anemia: Iron Deficiency, Vitamin B12 Deficiency, Folate (Vitamin B9) Deficiency
   Overview Iron Supplements and Vitamin D
   Vitamin B12
2) Poor Thyroid Function (Hypothyroidism)
   Thyroid and vitamin D are the only body components which have a receptor on every cell in the body
  Hypothyroidism risk reduced 32 percent in those getting vitamin D levels above 50 ng – Oct 2017
  The Role of Vitamin D in Thyroid Diseases – Sept 2017
3) Vitamin D Deficiency
4) Poor Liver Function
5) Low Testosterone Levels


Magnesium fights Fibromyalgia - a few PubMed studies

  • Magnesium and Fibromyalgia:A Literature Review - 2021 PDF
  • Fibromyalgia and nutrition: Therapeutic possibilities? July 2018 (Magnesium) 10.1016/j.biopha.2018.04.056
    amino acids, magnesium, selenium, vitamins B and D
  • Effects of transdermal magnesium chloride on quality of life for patients with fibromyalgia: a feasibility study Sept 2016 doi: 10.1016/S2095-4964(15)60195-9

A Wiki dedicated to ME/ Chronic Fatigue Syndrome

https://me-pedia.org/wiki 3,000 entries as of April 2021
Has an OK entry for Vitamin D and CFS


CFS sufferer for 25 years helped by improving his mitrocondria - May 2022

|https://tobyrogers.substack.com/p/chronic-pain-mecfs-post-exertional?s=r|Toby Rodgers]

  • He was helped by Sarah Myhill’s book, Diagnosis and Treatment of Chronic Fatigue Syndrome and Myalgic Encephalitis, 2nd ed.: It’s Mitochondria, Not Hypochondria
  • Johnson thinks ME/CFS is caused by a virus.8
  • "...estimated 1% of the global population has ME/CFS
  • took >20 years for him to be diagnosed as having ME/CFS
    • Note: on average the time is 7 years to be diagnosed

Short url = http://is.gd/fibrovitd

Overview Fibromyalgia or Chronic Fatigue and vitamin D        
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Attached files

ID Name Comment Uploaded Size Downloads
17959 Fibro 6 months.jpg admin 23 Jun, 2022 22:55 40.50 Kb 1535
17958 Fibro - Vitamin D and rehab.pdf PDF 2022 admin 23 Jun, 2022 22:55 293.48 Kb 194
17644 Mercola CFS 2022.pdf admin 22 May, 2022 22:36 116.47 Kb 144
17621 Mg Fibro review 2021.pdf PDF 2021 admin 19 May, 2022 10:30 381.41 Kb 155
14035 Impact of Fibromyalgia.pdf PDF 2020 admin 14 Jul, 2020 13:16 420.28 Kb 709
6197 Fibro Easy.jpg admin 30 Nov, 2015 03:05 75.09 Kb 53004
5032 Beyond CFS - IOM Feb 2015.pdf PDF 2015 admin 10 Feb, 2015 19:16 589.27 Kb 2153
4857 Pain level.jpg admin 11 Jan, 2015 15:47 49.55 Kb 32328
4856 Diganosis delay.jpg admin 11 Jan, 2015 14:38 58.53 Kb 33802
4462 Fibomyalgia.jpg admin 08 Oct, 2014 11:54 69.87 Kb 37647
4301 Overlap.jpg admin 20 Aug, 2014 12:04 61.41 Kb 68136
4300 Like me symptoms.jpg admin 20 Aug, 2014 11:58 30.29 Kb 33263
4299 Fibro survey comparison.jpg admin 20 Aug, 2014 11:17 45.43 Kb 38791
75 Patients Like Me Fibro.gif Patients Like Me CFS admin 10 Jun, 2010 02:44 28.17 Kb 8790