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Hemodialysis and Vitamin D - many studies


Hemodialysis patients reduced dementia chance by 60% if take 40,000 IU of vitamin D weekly – Aug 2023

The Protective Effect of Vitamin D on Dementia Risk in Hemodialysis Patients
Life 2023, 13(8), 1741; https://doi.org/10.3390/life13081741
by Chih-Lang Lin 1,2,3,†,Wan-Ming Chen 4,5,†,An-Tzu Jao 6,Ben-Chang Shia 4,5ORCID andSzu-Yuan Wu 4,5,6,7,8,9,10,11,*ORCID

Simple Summary
This study investigated the effect of vitamin D supplementation on the risk of dementia in patients with end-stage renal disease on hemodialysis, which is a novel contribution to the literature. To our knowledge, this is the first study to examine the relationship between vitamin D supplementation and the risk of dementia in this patient population. The use of a 1:1 propensity score-matched cohort design adds robustness and reliability to the study findings. The results demonstrated that vitamin D supplementation at doses of ≥70 μg/week significantly reduced the risk of dementia in a dose-dependent manner, regardless of age. These findings add new and important information to the existing literature on the relationship between vitamin D and cognitive health in ESRD patients on hemodialysis, and suggest that vitamin D supplementation may be an effective preventive strategy for cognitive impairment in this vulnerable patient population.

Abstract
Background: Patients with end-stage renal disease (ESRD) undergoing hemodialysis are at an elevated risk of developing dementia, potentially linked to the high prevalence of vitamin D deficiency in this population, which may contribute to cognitive impairment. Nevertheless, the impact of vitamin D supplementation on the risk of dementia in hemodialysis patients remains uncertain, necessitating further investigation to elucidate the potential benefits of vitamin D intervention in this vulnerable group.

Methods: In this propensity-score-matched comparative cohort study, we sought to assess the impact of vitamin D supplementation on the occurrence of dementia in patients with end-stage renal disease (ESRD) undergoing hemodialysis. A total of 1424 patients were included and matched 1:1 using propensity scores. The study population was divided into two groups: those receiving vitamin D supplementation at a dose of ≥70 μg/week and those without any supplementation. The primary outcome of interest was the incidence of dementia. We calculated adjusted hazard ratios (aHRs) to examine the association between vitamin D supplementation and the risk of dementia while controlling for relevant covariates.

Results: The adjusted hazard ratio (aHR) comparing vitamin D supplementation to no supplementation was 0.44 (95% CI 0.29–0.69; p < 0.0001), demonstrating a significant decrease in the risk of dementia associated with vitamin D supplementation. The aHRs for vitamin D supplementation at different dose ranges (70–105, 106–350, 351–1000, and >1000 μg/week) were 0.51, 0.49, 0.43, and 0.41, respectively (p for trend < 0.0001). These findings suggest a potential dose-dependent relationship between vitamin D supplementation and the reduction of dementia risk.

Conclusions: In our study, we found that vitamin D supplementation at doses of ≥70 μg/week significantly reduced the risk of dementia in patients with end-stage renal disease (ESRD) undergoing hemodialysis. Furthermore, our results indicated a dose-dependent effect, with higher doses of supplementation correlating with a greater reduction in dementia risk. These findings underscore the potential of vitamin D supplementation as a preventive approach for cognitive impairment in this high-risk population.
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Dementia is associated with low vitamin D - many studies

Hemodialysis patients probably helped by monthly 100,000 IU of Vitamin D - March 2023

The effects and safety of high dose vitamin D3 in hemodialysis patients
Pharm Pract (Granada) 2023 Jan-Mar;21(1):2773. doi: 10.18549/PharmPract.2023.1.2773
Adnane Guella 1, Abduelmula R Abduelkarem 2, Mohammed M Hassanein 3

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Background: Different studies have shown that hemodialysis patients require higher doses of Vitamin D3 (VD3) than the general population to achieve satisfactory replenishment. This study aims to assess the safety of such practice and its benefits on some of the parameters of Chronic Kidney Disease- Mineral and Bone Disorder (CKD-MBD).

Methods: A single-center clinical trial assessing the benefits of high dose VD3 in hemodialysis patients. The dose of VD3 (300,000 IU) was administered orally and monthly from April to December 2020 (9 months) at the dialysis unit. The data analyzed were blood levels of calcium, phosphorus, alkaline phosphatase, 25(OH)D, 1,25(OH)2D and intact parathyroid hormone (iPTH) done every three months.

Results: We could recruit a cohort of 23 patients. Blood levels of 25(OH)D increased significantly in 82.6% of the patients to above 30 ng/ml. A similar effect was observed with 1, 25(OH)2D levels. iPTH levels decreased significantly when levels of 25(OH)D exceeded 30ng/ml at the end of the nine months. Vitamin D serum levels were typically measured immediately before the next monthly dose was administered. Blood levels of calcium, phosphorus, and alkaline phosphatase were stable during the study period. No events of hypercalcemia were reported, and no patient discontinued the monthly VD3 supplementation.

Conclusion: Monthly administration of a high dose of VD3 over a long period of nine months in hemodialysis patients was found to be safe and beneficial in VD3 replenishment. It also allowed a significant decrease in iPTH levels. Further studies are warranted to identify the therapeutic target level of 25(OH)D in hemodialysis patients, allowing beneficial effects on iPTH.
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Long-term cholecalciferol supplementation in hemodialysis patients: Effects on mineral metabolism, inflammation, and cardiac parameters - Jan 2023

Semin Dial . 2023 Jan;36(1):29-36. doi: 10.1111/sdi.13066 publisher rents PDF for $12
Patrícia João Matias 1 2 3 4, Ivo Laranjinha 1 2 3, Gonçalo Ávila 1 2 3, Ana Azevedo 1 2 3, Cristina Jorge 1 2 3, Carina Ferreira 1 2 3 4, Inês Aires 1 2 3 4, Tiago Amaral 1 2 3, Célia Gil 1 2 3, Aníbal Ferreira 1 2 3 4

Background: Low levels of 25-hydroxyvitamin D [25(OH)D] are frequent in chronic kidney disease and are associated with adverse outcomes. The aim of this 5-year prospective study was to evaluate the effects of cholecalciferol supplementation on mineral metabolism, inflammation and cardiac parameters in hemodialysis (HD) patients.

Methods: The study included 97 patients. Cholecalciferol was given after HD according to 25(OH)D baseline levels measured twice (end of winter and of summer). The 25(OH)D levels, circulating bone metabolism, inflammation parameters, brain natriuretic peptide (BNP), pulse pressure (PP), and left ventricular mass index (LVMI) were evaluated before and after supplementation.

Results: There was a significant increase in 25(OH)D levels after supplementation (p < 0.001); however, serum calcium (p = 0.02), phosphorus (p = 0.018), and iPTH (p = 0.03) were decreased. Magnesium levels increased during the study (p = 0.03). A reduction in the number of patients under active vitamin D (p < 0.001) and in the dose and number of patients treated with darbepoetin (p = 0.02) was observed. Serum albumin increased (p < 0.001), and C-reactive protein decreased (p = 0.01). BNP (p < 0.001), PP (p = 0.007), and LVMI (p = 0.02) were significantly reduced after supplementation.

Conclusions: Long-term cholecalciferol supplementation allowed correction of 25(OH)D deficiency, improved mineral metabolism with less use of active vitamin D, attenuated inflammation, reduced the dose of the erythropoiesis-stimulating agent, and improved cardiac dysfunction.


More Hemodialysis pain if low vitamin D - Jan 2023

Vitamin D level, pain severity and quality of life among hemodialysis patients: a cross-sectional study
Sci Rep .2023 Jan 21;13(1):1182. doi: 10.1038/s41598-022-25793-z.
Shaima Ishtawi 1, Dana Jomaa 1, Aisha Nizar 1, Mazen Abdalla 2, Zakaria Hamdan 3, Zaher Nazzal 4

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This cross-sectional study aims to find the prevalence of chronic pain and its correlation with the quality of life and vitamin D levels among hemodialysis patients in Palestine. We used the brief pain inventory, the medical outcomes study 36-item short-form health survey, and Serum 25-hydroxyvitamin D to assess chronic pain, quality of life, and vitamin D levels, respectively. The study included 200 patients, 38.1% (95% confidence interval 31.3-45.4%) of whom had chronic pain, and 77.7% (95% confidence interval 71.0-83.4%) had deficient Vitamin D levels. Quality of life scores were generally low, with the lowest in role emotional and physical functioning. Sex, comorbidities, and vitamin D level significantly correlate with pain severity. Employment, number of comorbidities, pain severity, and albumin level are significantly associated with the Physical component of quality of life. On the other hand, employment and pain severity are significantly related to the mental component of quality of life. In conclusion, low vitamin D levels, chronic pain, and low quality of life scores are common among hemodialysis patients. In addition, vitamin D is negatively correlated with pain severity. Therefore, healthcare workers should assess and manage hemodialysis patients' chronic pain to improve their quality of life and reduce suffering.
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38+ VitaminDWiki pages with HEMODIALYSIS etc in title

This list is automatically updated

Items found: 38
Title Modified
Hemodialysis and Vitamin D - many studies 20 Jan, 2023
Kidney Dialysis, low Vitamin D, low Magnesium - many studies 02 Nov, 2022
Poor cognition 2X more likely in Hemodialysis Patients if low Vitamin D – Sept 2022 20 Sep, 2022
Dialysis patients 23 percent more likely to live if had just 10 ng more Vitamin D – meta-analysis Feb 2018 29 Sep, 2021
Peritoneal dialysis probably consumes a lot more vitamin D than haemodialysis 29 Sep, 2021
Hemodialysis associated with very poor mRNA response (wonder if low vitamin D) – March 26, 2021 31 Mar, 2021
2.8X more likely to die of hemodialysis if low on vitamin D 26 Mar, 2021
Patients on Hemodialysis 3X more likely if die of heart failure if low Magnesium – meta-analysis Jan 2021 26 Mar, 2021
Vitamin D is needed during Dialysis – initially only 29 pcnt tested, extensive education raised it to 32 pcnt – May 2020 28 Feb, 2021
Kidney Dialysis often filters out Vitamin D, a problem for vegetarians and others- Feb 2021 14 Feb, 2021
Hemodialysis with low vitamin D increases risk of 2 health problems by 10 percent – Aug 2020 06 Aug, 2020
Hemodialysis deaths less likely if take vitamin D, especially if highest dose vitamin D – Nov 2018 10 Nov, 2018
Dialysis patients who added Vitamin D were 41 percent less likely to get infection – Meta-analysis July 2018 31 Jul, 2018
Vitamin D Receptor activators (such as paricalcitol) treat dialysis patients similarly – Aug 2017 27 Aug, 2017
Hemodialysis patients (CKD) helped by weekly 50,000 IU of vitamin D – Jan 2017 27 Jul, 2017
Kidney Dialysis clinics reluctant to add vitamin D treatment as they are not reimbursed – Oct 2012 27 Jul, 2017
Low vitamin D associated with hemodialysis problems – May 2010 13 Mar, 2017
Peritoneal dialysis probably consumes a lot more vitamin D than haemodialysis – April 2014 24 Jun, 2016
Hemodialysis low vitamin D status was normalized with 28500 IU avg daily – Jan 2012 10 Oct, 2015
Hemodialysis not helped by weekly vitamin D2 – RCT April 2015 08 Apr, 2015
Dialysis patients need real vitamin D – Editorial July 2013 08 Apr, 2015
Peritoneal Dialysis nicely treated by active vitamin D – July 2013 04 Feb, 2015
1700 IU of vitamin D not enough to help hemodialysis patients – March 2013 13 Jan, 2015
25,0000 IU vitamin D weekly only raised 60 percent on hemodialysis above 30 ng – Nov 2014 13 Jan, 2015
Application to FDA for use of active Vitamin D for hemodialysis patients – July 2011 18 Feb, 2014
Those Dialysis patients with low vitamin D were 75% more likely to die – July 2013 12 Dec, 2013
Vitamin D3 far better than D2 for hemodialysis – Oct 2012 24 Aug, 2013
Virtually all black dialysis patients with low albumin are vitamin D deficient in the winter – Mar 2010 23 Jul, 2013
Dialysis patients with less than 15 ng of vitamin D did not feel well – March 2011 23 Jul, 2013
Dialysis patients with low vitamin D were 2.7 X more likely to die of heart problems – Feb 2011 23 Jul, 2013
Vitamin D tester falsely said half of hemodialysis patients had less than 30 ng – Jan 2013 01 Jun, 2013
Telomeres longer for dialysis patients having higher levels of vitamin D – March 2012 11 May, 2013
5700 IU of vitamin D helped half with chronic kidney disease if not having dialysis – July 2012 01 Sep, 2012
Majority of blacks on dialysis were vitamin D deficient - March 2010 12 Nov, 2011
Dialysis patients with higher levels of vitamin D were better – May 2011 24 May, 2011
Wearable dialysis device being tested which also converts vitamin D - Mar 2011 04 Mar, 2011
Clinical measures identify vitamin D deficiency in dialysis – Feb 2010 19 Jul, 2010
1700 IU per day of vit D2 was not enough to help dialysis No value for &#039;modification_date_major&#039;

Attached files

ID Name Comment Uploaded Size Downloads
20036 Hemodialysis 40K weekly_CompressPdf.pdf admin 30 Aug, 2023 248.34 Kb 70
19511 Hemo 100K.jpg admin 25 Apr, 2023 23.92 Kb 215
19510 Hemo 100K.pdf admin 25 Apr, 2023 294.83 Kb 149
19128 Hemo pain.jpg admin 22 Jan, 2023 70.53 Kb 287
19127 hemodialysis pain.pdf admin 22 Jan, 2023 894.33 Kb 230