- Dietary interventions for perinatal depression and anxiety: a systematic review and meta-analysis of randomized controlled trials
- VitaminDWiki -
21 studies in both categories Pregnancy and Depression - FDA announced fast-acting Zurzuvae pill for postpartum depression - Aug 2023
- To be fast acting, Vitamin D needs to start with a loading dose (otherwise it takes many months)
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Dietary interventions for perinatal depression and anxiety: a systematic review and meta-analysis of randomized controlled trials
Am J Clin Nutr. 2023 Apr 3;S0002-9165(23)46315-0. doi: 10.1016/j.ajcnut.2023.03.025 PDF is behind a paywall
Zoe Tsai 1, Nirmay Shah 2, Umair Tahir 2, Neda Mortaji 3, Sawayra Owais 4, Maude Perreault 5, Ryan J Van Lieshout 3Background: Dietary interventions are a widely available intervention for depression and anxiety among pregnant and/or postpartum (i.e., perinatal) persons but their effectiveness is not well known.
Objective: We performed a systematic review and meta-analysis to assess the effectiveness of dietary interventions for the treatment of perinatal depression and/or anxiety.
Design: We searched Medline, EMBASE, PsycINFO, CINAHL, and Web of Science from their inception to November 2, 2022. Studies were included if they were available in English and examined the effectiveness of a dietary intervention for perinatal depression and/or anxiety in a randomized controlled trial.
Results: Our search identified 4,246 articles, 36 of which were included and 28 were eligible for meta-analysis. Random effects meta-analyses were performed.
- Polyunsaturated fatty acids (PUFAs) were not found to improve symptoms of perinatal depression compared to control conditions (SMD -0.11; 95% CI -0.26 to 0.04). These results did not change when examined during pregnancy or the postpartum period separately, nor did they vary according to fatty acid ratio.
- Elemental metals (iron, zinc, and magnesium) were also not found to be superior to placebo (SMD, -0.42; 95% CI, -1.05 to 0.21), though,
- vitamin D yielded a small to medium effect size improvements (SMD, -0.52; 95% CI, -0.84 to -0.20) in postpartum depression.
- Iron may help in those with confirmed iron deficiency. Narrative synthesis was performed for studies ineligible for meta-analyses.
Conclusions: Despite their widespread popularity, PUFAs and elemental metals do not appear to effectively reduce perinatal depression. Vitamin D taken in doses of 1800 to 3500 International Units (IU) per day may have some promise. Additional high-quality, large-scale randomized controlled trials (RCTs) are needed to determine the true effectiveness of dietary interventions on perinatal depression and/or anxiety.
VitaminDWiki -
21 studies in both categories Pregnancy and Depression This list is automatically updated
- Only Vitamin D was found to treat post-partum depression - Meta-analysis April 2023
- Postpartum depression 3.6 X higher risk if low vitamin D – Jan 2022
- ADHD 3.7 X higher risk if depressed pregnancy (low vitamin D) – Dec 2020
- Depression after childbirth 5 X less likely if good Omega-3 index – April 2019
- Postpartum Depression 3.3 X more likely if low vitamin D – Oct 2018
- Vitamin D prevents pregnancy depression (US Prevention Task Force say it cannot be prevented) - Feb 2019
- Depressed black pregnant women should take vitamin D – April 2018
- Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017
- Perinatal depression decreased 40 percent with just a few weeks of 2,000 IU of vitamin D – RCT Aug 2016
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Depression in youths associated with low vitamin D during pregnancy – Oct 2014
- Postpartum depression 7X more likely if less than 10 ng of vitamin D – Sept 2014
- Depression after pregnancy and vitamin D – Nov 2013
- Depression and Vitamin D during Pregnancy – Dissertation Aug 2014
- Depression during pregnancy twice as likely if consume little vitamin D – July 2014
- Antidepressants might increase infertility and pregnancy problems – Nov 2012
- Association between season of birth and suicide – perhaps vitamin D – Sept 2012
- Depression 50 percent more likely if low vitamin D in early pregnancy – Aug 2012
- Pregnant blacks 50 pcnt more likely to be depressed if 3 ng less vitamin D – July 2012
- Depressed mothers more likely to have small babies – Aug 2010
- An Exploratory Study of Postpartum Depression and Vitamin D - May 2010
FDA announced fast-acting Zurzuvae pill for postpartum depression - Aug 2023
- "The FDA warned that the drug’s side effects can include drowsiness, dizziness, fatigue, diarrhea, urinary tract infection and nasopharyngitis (the common cold)."
- A persion "cautioned that Zurzuvae is not a “magic pill” for broadly solving postpartum depression."
To be fast acting, Vitamin D needs to start with a loading dose (otherwise it takes many months)
Millions of people have all successfully use Vitamin D loading doses.
There are an extremely wide variety of loading dose protocols, all of which work
50,000 IU of vitamin D daily for a week is one example
Hundreds of studies are compared at Overview Loading of vitamin D
There have been
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