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Pneumonia Risk, intensity, and mortality all associated with low vitamin D


Pneumonia in VitaminDWiki

Graph shows a 40% chance of wheezing at age 80 if have less than 10 nanograms of vitamin D
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Children and Pneumonia


Pneumonia in peer-reviewed medical publications (PubMed)

  • Effect of Adjunctive Single High-Dose Vitamin D 3 on Outcome of Community-Acquired Pneumonia in Hospitalised Adults: The VIDCAPS Randomised Controlled Trial - Sept 2018  Download the RCT PDF from VitaminDWiki
    • 17X more likely for Pneumonia to go away in those starting with <10 ng and getting a single dose of 200,000 IU of Vitamin D
    • Note: Not statistically significant
  • The Association Between Vitamin D Deficiency and Community-Acquired Pneumonia: A Meta-Analysis of Observational Studies - Sept 2019
  • Effect of Vitamin D Supplementation in the Prevention of Recurrent Pneumonia in Under-Five Children - Dec 2019,DOI: 10.1007/s12098-019-03025-z
    • 300,000 IU given quarterly No such attachment on this page
  • Vitamin D Supplementation for Treatment and Prevention of Pneumonia in Under-five Children: A Randomized Double-blind Placebo Controlled Trial - Aug 2016  Download the RCT PDF from VitaminDWiki
    • 100,000 IU temporaily raised vitamin D levels by an average of 30 ng, not much benefit (needed much larger dose)

Pneumonia in the web

  • Vitamin D Council Pneumonia summary for patients - May 2014
  • https://en.wikipedia.org/wiki/Pneumonia
    "Pneumonia affects approximately 450 million people globally (7% of the population) and results in about 4 million deaths per year"
    "Pneumonia often shortens suffering among those already close to death and has thus been called "the old man's friend"."
    "Pneumonia is due to infections caused primarily by bacteria or viruses and less commonly by fungi and parasites."
    "Conditions and risk factors that predispose to pneumonia include
    • smoking, immunodeficiency, alcoholism, chronic obstructive pulmonary disease, asthma, chronic kidney disease, and liver disease."
    • Note by VitaminDWiki - every one of those risk factors is also associated with low vitamin D levels
  • https://en.wikipedia.org/wiki/Community-acquired_pneumonia much less likely to be due to a superbug
  • Sunshine, rainfall, humidity and child pneumonia in the tropics: time-series analyses June 2013
    "Lack of sunshine was most strongly associated with pneumonia in both lagged regression. . . and case-crossover analysis"
    "This association is well known in temperate settings but has not been noted previously in the tropics"
  • Search Google for heliotherapy pneumonia 31,000 items
    sun therapy for pneumonia, TB, etc. was common before the invention of antibiotics
  • Be in the Know About Pneumonia Mercola June 2016?
    "These rates resulted in pneumonia being addressed as the eighth leading cause of death in the U.S., tied with influenza."
    ". . .it’s one of the two main causes of hospitalization, apart from childbirth."

Pneumonia elderly death 12X more likely when vitamin D less than 12 ng – 2011

Vitamin D, Innate Immunity and Outcomes in Community Acquired Pneumonia
1. Leong Leow1, 2. Talia Simpson3, 3. Ray Cursons3, 4. Noel Karalus1, 5. Robert J Hancox1,2,*
DOI: 10.1111/j.1440-1843.2011.01924.x
© 2011 The Authors. Respirology © 2011 Asian Pacific Society of Respirology, Respirology

Background and objective Vitamin D regulates the production of the antimicrobial peptides cathelicidin and beta defensin-2, which play an important role in the innate immune response to infection. We hypothesised that vitamin D deficiency would be associated with lower levels of these peptides and worse outcomes in patients admitted to hospital with community-acquired pneumonia.

Methods Associations between mortality and serum levels of 25-hydroxyvitamin D, cathelicidin, and beta defensin-2 were investigated in a prospective cohort of 112 patients admitted with community-acquired pneumonia during winter.

Results Severe 25-hydroxyvitamin D deficiency (<30nmol/L) was common in this population (15%) and was associated with a higher 30-day mortality compared to patients with sufficient 25-hydroxyvitamin D(>50nmol/L) (OR 12.7, 95%CI 2.2-73.3, p = 0.004).

These associations were not explained by differences in age, co-morbidities, or the severity of the acute illness.
Neither cathelicidin nor beta defensin-2 levels predicted mortality, although there was a trend towards increased mortality with lower cathelicidin (p = 0.09).
Neither cathelicidin nor beta defensin-2 levels correlated with 25-hydroxyvitamin D.

Conclusions 25-hydroxyvitamin D deficiency is associated with increased mortality in patients admitted to hospital with community-acquired pneumonia during winter.
Contrary to our hypothesis, 25-hydroxyvitamin D levels were not associated with levels of cathelicidin or beta defensin-2.

 Download the PDF from VitaminDWiki


Type of Pneumonia: viral, bacterial, fungal

Scientific Animations
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https://www.cdc.gov/media/releases/2015/p0714-pneumonia-hospitalizations.html25% of Pneumonia is viral (Rhenovirus, Influenza, etc,) - CDC

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Created by admin. Last Modification: Wednesday April 1, 2020 18:42:40 GMT-0000 by admin. (Version 55)
Pneumonia Risk, intensity, and mortality all associated with low vitamin D        
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Attached files

ID Name Comment Uploaded Size Downloads
13532 Pneumonia 300,000 IU.pdf admin 24 Feb, 2020 17:31 143.25 Kb 99
13436 Pathogens-causing-pneumonia_180607_04.jpg admin 03 Feb, 2020 11:32 1,015.72 Kb 1091
13420 Pneumonia RCT 100,000.pdf admin 30 Jan, 2020 03:24 589.46 Kb 128
13419 VIDCAPS RCT.pdf PDF 2019 admin 30 Jan, 2020 02:41 1.05 Mb 165
13418 Pneunomia meta 2019.pdf PDF 2019 admin 30 Jan, 2020 02:26 773.80 Kb 154
10908 Vitamin D, Innate Immunity and Outcomes in Community Acquired Pneumonia.pdf admin 26 Nov, 2018 02:32 296.43 Kb 422
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