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Pancreatitis and Vitamin D - many studies


Vitamin D: A Potential Star for Treating Chronic Pancreatitis - June 2022

Front. Pharmacol., 06 June 2022 | https://doi.org/10.3389/fphar.2022.902639
Meifang Zheng and Runping Gao*
Department of Hepatic Biliary Pancreatic Medicine, The First Hospital of Jilin University, Changchun, China

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Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the pancreas. The incidence of CP is increasing worldwide but the effective therapies are lacking. Hence, it is necessary to identify economical and effective agents for the treatment of CP patients. Vitamin D (VD) and its analogues have been confirmed as pleiotropic regulators of cell proliferation, apoptosis, differentiation and autophagy. Clinical studies show that VD deficiency is prevalent in CP patients. However, the correlation between VD level and the risk of CP remains controversial. VD and its analogues have been demonstrated to inhibit pancreatic fibrosis by suppressing the activation of pancreatic stellate cells and the production of extracellular matrix. Limited clinical trials have shown that the supplement of VD can improve VD deficiency in patients with CP, suggesting a potential therapeutic value of VD in CP. However, the mechanisms by which VD and its analogues inhibit pancreatic fibrosis have not been fully elucidated. We are reviewing the current literature concerning the risk factors for developing CP, prevalence of VD deficiency in CP, mechanisms of VD action in PSC-mediated fibrogenesis during the development of CP and potential therapeutic applications of VD and its analogues in the treatment of CP.
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Vitamin D and Pancreatitis: A Narrative Review of Current Evidence - May 2022

Nutrients 2022, 14(10), 2113; https://doi.org/10.3390/nu14102113
by Fei Cai 1,†ORCID,Cheng Hu 1,†ORCID,Chan-Juan Chen 1,Yuan-Ping Han 2,Zi-Qi Lin 1,Li-Hui Deng 1,* andQing Xia 1
1 Department and Laboratory of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China
2 The Center for Growth, Metabolism and Aging, College of Life Sciences, Sichuan University, Chengdu 610017, China

Emerging research indicates that vitamin D metabolic disorder plays a major role in both acute pancreatitis (AP) and chronic pancreatitis (CP). This has been demonstrated by studies showing that vitamin D deficiency is associated with pancreatitis and its anti-inflammatory and anti-fibrotic effects by binding with the vitamin D receptor (VDR). However, the role of vitamin D assessment and its management in pancreatitis remains poorly understood. In this narrative review, we discuss the recent advances in our understanding of the molecular mechanisms involved in vitamin D/VDR signaling in pancreatic cells; the evidence from observational studies and clinical trials that demonstrate the connection among vitamin D, pancreatitis and pancreatitis-related complications; and the route of administration of vitamin D supplementation in clinical practice. Although further research is still required to establish the protective role of vitamin D and its application in disease, evaluation of vitamin D levels and its supplementation should be important strategies for pancreatitis management according to currently available evidence.
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Osteoporosis is 1.9X more likely if have Acute Pancreatitis - 2020

The Risk of Vitamin D Deficiency, Osteoporosis, and Fractures in Acute Pancreatitis
Pancreas: 5/6 2020 - p 629-633 doi: 10.1097/MPA.0000000000001538 PDF behind paywall
Abou Saleh, Mohannad MD∗; Alkhayyat, Motasem MD†; Mansoor, Emad MD‡; Khoudari, George MD†; Simons-Linares, C. Roberto MD∗; Vargo, John MD∗; Chahal, Prabhleen MD∗; Stevens, Tyler MD∗

Objectives
A few past studies have found increased utilization of 25-hydroxyvitamin D and prevalence of osteoporosis in acute pancreatitis (AP). Our aim was to obtain a survey of bone diseases after a sentinel episode of AP.

Methods
A database (Explorys), an aggregate of electronic health record from 26 integrated United States healthcare systems, was queried. A cohort of patients with a Systematized Nomenclature of Medicine—Clinical Terms diagnosis of AP between 2014 and 2019, after excluding patients with selected medical conditions and medications that are associated with poor bone health, was identified. The prevalence of new diagnoses of vitamin D deficiency (VDD), osteoporosis, and fractures in the study cohort was evaluated. Age-, race-, and sex-based distributions and risk factors were determined through univariate and multivariate analyses.

Results
Of the 36,087,380 individuals in the database, we identified 256,580 (0.71%) with AP. In multivariate analysis, patients with AP were more likely to develop VDD (odds ratio OR, 1.25; 95% confidence interval CI, 1.24–1.26; P < 0.0001), osteoporosis (OR, 1.89; CI, 1.81–1.85; P < 0.0001), and fractures (OR, 1.58; 95% CI, 1.57–1.59; P < 0.0001).

Conclusions
Acute pancreatitis was associated with increased risk of VDD, osteoporosis, and fractures.


Systematic review and meta-analysis on the prevalence of vitamin D deficiency in patients with chronic pancreatitis - 2016

Pancreatology, Available online 18 July 2016, doi:10.1016/j.pan.2016.07.010
S.A. Hoogenbooma, 1, S.J. Lekkerkerkera, 1, P. Fockensa, M.A. Boermeesterb, J.E. van Hoofta, ,

Background/Objectives
Patients with chronic pancreatitis (CP) are at risk of malnutrition due to malabsorption, pain and/or alcohol consumption. This can cause vitamin D insufficiency or deficiency, which is associated with osteoporosis and increased risks of fractures. We aimed to perform a meta-analysis to determine the prevalence of vitamin D insufficiency and deficiency in CP patients. Furthermore, we compared these results with healthy controls.

Methods
We performed a systematic review and meta-analysis on the literature by searching PubMed and EMBASE (January 2000–December 2015) on CP and vitamin D. Primary outcome was prevalence of vitamin D insufficiency (<75 nmoL/L) and deficiency (<50 nmoL/L) in CP patients. When available, data of CP patients were compared with healthy controls.

Results
Nine studies were included in our meta-analysis, reporting on the prevalence of vitamin D insufficiency/deficiency in 465 patients (mean age 41 years (range 18–60), 81% male) and in 378 controls (mean age 40 years (range 18–67), 76% male). Pooled prevalence of vitamin D insufficiency and deficiency in CP patients was 83% and 65%, respectively. Calculated odds ratio (OR) of vitamin D insufficiency and deficiency between CP patients and controls was 1.34 (0.54–3.29) and 1.14 (0.70–1.85), respectively (p > 0.05).

Conclusion
There is a high prevalence of vitamin D insufficiency and deficiency in CP patients. Nevertheless, there is no significant difference in prevalence of vitamin D insufficiency and deficiency compared to healthy controls. Further research should indicate the clinical relevance and consequences of these findings for clinical practice.
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Fat-soluble vitamin deficiency and exocrine pancreatic insufficiency among adults with chronic pancreatitis: Is routine monitoring necessary for all patients? - Oct 2023

Nutr Clin Pract . 2023 Oct 15. doi: 10.1002/ncp.11082 PDF is behind a paywall
Holly Estes-Doetsch 1 2, Kristen Roberts 1 2, Melanie Newkirk 3, Anna Parker 3

Chronic pancreatitis (CP) is often associated with exocrine pancreatic insufficiency (EPI), which may increase risk for fat-soluble vitamin depletion. Although vitamin D deficiency is widespread among the general population, vitamins A, E, and K deficiencies may more uniquely present in patients with CP. Yet, it is unclear whether fat-soluble vitamin status should be routinely monitored in all patients with CP or limited to those with EPI. The purpose of this review is to describe the laboratory status of vitamins A, E, and K in adult patients with CP and their association with exocrine pancreatic function. Five primary, observational studies met the inclusion criteria for qualitative synthesis. Biochemical deficiencies in fat-soluble vitamins were observed across trials but results varied with respect to whether EPI increased risk. Challenges related to the diagnosis and treatment of EPI along with potential confounders may contribute to the heterogeneity among study results. Although more studies are needed to determine the influence of pancreatic enzyme replacement therapy on fat-soluble vitamin status as well as effective vitamin repletion strategies, clinicians should consider periodically screening for deficiencies in all patients with CP regardless of EPI to avoid associated health effects of vitamin depletion.


Fat-Soluble Vitamin Deficiencies and Disruption of the Immune System in Pancreatic Cancer- A Vicious Cycle - Sept 2022

Pancreas 51(8):p 923-929, September 2022. | DOI: 10.1097/MPA.0000000000002128
Aziz, Mohammad Hosein MD∗; van der Meulen, Jan MD, PhD†; Mustafa, Dana A.M. PhD†,‡; van Eijck, Casper H. J. MD, PhD†,‡

Pancreatic ductal adenocarcinoma (PDAC) is currently an increasing contributor to cancer-related mortality. Despite advances in cancer treatment, PDAC survival rates have remained roughly unchanged over the years. Specifically, late diagnosis and insensitivity to currently available therapeutic regimens have been identified as the main causes for its poor survival. Pancreatic exocrine insufficiency (PEI) is a typical complication associated with PDAC diagnosis and pancreatic surgery. Pancreatic exocrine insufficiency, a major contributor to maldigestion in PDAC, is often not treated because it remains undetected because of lack of overt signs and symptoms. In this review, we will focus on the major consequences of PEI, including the inadequacy of lipase excretion, which results in deficiency of fat-soluble vitamins. Because PDAC is known for its immune-high jacking mechanisms, we describe key features in which deficiencies of fat-soluble vitamins may contribute to the aggressive biological behavior and immune evasion in PDAC. Because PEI has been shown to worsen survival rates in patients with PDAC, detecting PEI and the related fat-soluble vitamin deficits at the time of PDAC diagnosis is critical. Moreover, timely supplementation of pancreatic enzymes and fat-soluble vitamins may improve outcomes for PDAC patients.
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Pancreatitis associated with poor Vitamin D Binding Protein and Receptor (in dogs) July 2023

DOI: 10.1111/jvim.16809 FREE PDF


VitaminDWiki Inflammation pages with PANCREATITIS in title (6 as of June 2022)

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Vitamin D and Pancreatitis: A Narrative Review of Current Evidence - May 2022

Nutrients 2022, 14(10), 2113; https://doi.org/10.3390/nu14102113
by Fei Cai 1,†ORCID,Cheng Hu 1,†ORCID,Chan-Juan Chen 1,Yuan-Ping Han 2,Zi-Qi Lin 1,Li-Hui Deng 1,* and Qing Xia 1

Emerging research indicates that vitamin D metabolic disorder plays a major role in both acute pancreatitis (AP) and chronic pancreatitis (CP). This has been demonstrated by studies showing that vitamin D deficiency is associated with pancreatitis and its anti-inflammatory and anti-fibrotic effects by binding with the vitamin D receptor (VDR). However, the role of vitamin D assessment and its management in pancreatitis remains poorly understood. In this narrative review, we discuss the recent advances in our understanding of the molecular mechanisms involved in vitamin D/VDR signaling in pancreatic cells; the evidence from observational studies and clinical trials that demonstrate the connection among vitamin D, pancreatitis and pancreatitis-related complications; and the route of administration of vitamin D supplementation in clinical practice. Although further research is still required to establish the protective role of vitamin D and its application in disease, evaluation of vitamin D levels and its supplementation should be important strategies for pancreatitis management according to currently available evidence.
 Download the PDF from VitaminDWiki


See also: The global, regional, and national burden of pancreatitis in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

https://doi.org/10.1186/s12916-020-01859-5 many charts, FREE PDF

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Created by admin. Last Modification: Monday October 16, 2023 14:17:32 GMT-0000 by admin. (Version 23)

Attached files

ID Name Comment Uploaded Size Downloads
20235 Pancreatitis Narrative Review_CompressPdf.pdf admin 16 Oct, 2023 280.04 Kb 52
20234 Pancreatic Cancer - A Vicious Cycle.docx admin 16 Oct, 2023 83.57 Kb 56
20233 hoogenboom2016 sci-hub_CompressPdf.pdf admin 16 Oct, 2023 487.42 Kb 58
17855 CP Table 4.jpg admin 13 Jun, 2022 90.19 Kb 432
17854 CP Table 3.jpg admin 13 Jun, 2022 155.78 Kb 441
17853 CP table 1.jpg admin 13 Jun, 2022 134.24 Kb 473
17852 Pancreatitis narrative.pdf admin 13 Jun, 2022 888.22 Kb 281
17851 Vitamin_D_A_Potential_Star_for_Treating_Chronic_Pa_CompressPdf.pdf admin 13 Jun, 2022 799.24 Kb 235