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Miscarriage and low Vitamin D – many studies

Miscarriage < 20 weeks    (Stillbirth >20 weeks)

Vitamin D insufficiency as a risk factor for reproductive losses in miscarriage
Gynecol Endocrinol . 2021;37(sup1):8-12. doi: 10.1080/09513590.2021.2006451.
V E Radzinsky 1, F U Ramazanova 1, M B Khamoshina 1, M M Azova 1, M R Orazov 1, A A Orazmuradov 1

Objective: To study the relationship between vitamin D deficiency, VDR gene polymorphism rs10735810 (A > G), and a missed abortion in the first trimester of gestation; to determine the predictors of its risk.

Research methods: 178 women aged between 18 and 41 were surveyed. The main group consisted of patients with miscarriage (n = 101), verified at the hospital stage (O02.0; O02.1), which were stratified by I group (n = 58, patients with the first miscarriage) and II groups (n = 43, patients with repeated miscarriage). The control group (n = 77) consisted of women with a successful pregnancy (Z34.0), which subsequently ended in delivery at term with a live fetus. Patients were surveyed and data was extracted from primary medical records. The level of 25(OH)D in the blood serum was investigated by mass spectrometry (n = 99). Genotyping for the vitamin D receptor gene polymorphism rs10735810 (VDR A > G) was performed for 177 patients. Statistical data analysis was performed via Statistica 10 and SAS JMP 11 application packages, using single-factor prediction for quantitative and binary factors, ROC analysis, and CHAID decision tree construction.

Results of the study: WE found that patients with miscarriage in the first trimester of gestation (n = 60) more frequently than those in the control group (n = 39) had vitamin D insufficiency (93.3% versus 76.9%, p = .0183) including its deficiency, occurring at 25(OH)D of blood <20 ng/ml (71.7% versus 51.3%, p = .0392). This pattern was found in patients with the first miscarriage, where significant differences in the frequency of vitamin D deficiency were also detected in comparison with the control group (80.0% versus 51.3%, p = .0026). No direct correlation was found between the frequency of miscarriages in the first trimester and the variant of the polymorphism of the vitamin D receptor gene (VDR A > G [rs10735810]); the GG genotype in patients with repeated miscarriages was even less frequent compared to the control group (14.0% versus 23.7%, p = .3344). However, the decision tree has identified four risk classes and has determined that the highest risk of missed abortion in the cohort studied is formed by three predicates: smoking, serum level 25(OH)D < 6.5 ng/ml and VDR AA and GG genotypes.

Conclusion: The data obtained show that vitamin D insufficiency plays a pathogenetically significant role in early reproductive losses associated with miscarriages, both first and recurrent.
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VitaminDWiki - The list of 4 associations

Low Vitamin Dlow D in Blood
SmokingLow D in blood - typically 10 ng lower
Low Vitamin D is worse for your health than smoking
Poor Vitamin D Receptor - ALow D in cell of the placenta or fetus
Poor Vitamin D Receptor - Blow D in cell of he placenta or fetus

36+ VitaminDWiki pages have MISCARRIAGE in the title

This list is automatically updated

Items found: 37
Title Modified
Miscarriage and low Vitamin D – many studies 03 Apr, 2024
Accutane for acne associated with birth defects, abortions - April 2024 02 Apr, 2024
Miscarriage (Recurrent Spontaneous) associated with poor CYP27B1 gene - Jan 2024 01 Feb, 2024
Recurrent miscarriages decreased by increased Vitamin D levels - Jan 2024 29 Jan, 2024
Miscarriage 2.5X more likely if second-hand smoke and low vitamin D – Sept 2022 06 Sep, 2022
Miscarriage 1.6 X more likely if low vitamin D – meta-analysis May 2022 09 Jun, 2022
Recurrent Miscarriage 4X more likely if low vitamin D – meta-analysis June 2022 07 Jun, 2022
Recurrent pregnancy loss (miscarriage) risk should be reduced by vitamin D, vitamin B12 – March 2021 24 Dec, 2021
Researchers found flu vaccine increased miscarriage risk by 7X -Sept 2017 24 Dec, 2021
Recurrent miscarriage associated with low Vitamin D – Nov 2013 24 Dec, 2021
Recurrent pregnancy loss (miscarriage) is associated with low vitamin D in 6 ways – March 2021 25 Mar, 2021
Recurrent miscarriage occurs 2.2 more often if poor Vitamin D Receptor – Aug 2019 26 Feb, 2021
Spontaneous Miscarriage strongly associated with 2 vitamin D genes – March 2020 15 Feb, 2020
Preterm birth 9 X more likely if fetus had a poor Vitamin D Receptor and previous miscarriage – Aug 2017 12 Nov, 2019
Miscarriage 32 percent more likely if work night shift (probably low Vitamin D) – April 2019 05 Apr, 2019
Miscarriage 2 times more likely if low vitamin D – meta-analysis May 2017 05 Apr, 2019
Miscarriage 10 percent more likely for each 10 ng less vitamin D at preconception – May 2018 01 Aug, 2018
More pregnancies and fewer abortions when Omega-3 was added (cows in this case) July 2018 31 Jul, 2018
Miscarriages strongly associated with poor placental, decidua gene which locally activates Vitamin D – Dec 2016 28 Jul, 2018
Second miscarriage associated with low vitamin D – review June 2018 20 Jun, 2018
Pregnancies with more than 40 ng of vitamin D are great - miscarriage, LBW, SGA, preterm – Feb 2018 14 Feb, 2018
Pregnancies with more than 40 ng of vitamin D are great - miscarriage, LBW, SGA, preterm – Feb 2018 14 Feb, 2018
Cesarean (associated with low Vitamin D) increased asthma, obesity, miscarriage and stillbirth – meta-analysis Jan 2018 26 Jan, 2018
Early menarche, miscarriage and stillbirth are associated with heart disease (all are associated with low Vitamin D) – Jan 2018 18 Jan, 2018
Preterm birth far more likely if previous miscarriage and poor Vitamin D receptor – Aug 2017 20 Nov, 2017
APS (associated with miscarriage, stillbirth. preterm delivery and stroke) is 3X more likely if low vitamin D – meta-analysis Oct 2017 13 Oct, 2017
Frequent miscarriage associated with both lower vitamin D and poor Vitamin D receptor – Sept 2017 14 Sep, 2017
Miscarriage in first trimester 2.5X more likely if less than 20 ng of vitamin D – July 2015 07 Jul, 2017
Miscarriage 70 percent more likely if low vitamin D (see also data on CYP27B1) – May 2016 07 Jul, 2017
Just 400 IU of daily Vitamin D reduced miscarriage (recurrent) by 3.5 times – RCT July 2016 07 Jul, 2017
Preterm birth 2X more likely if poor Vitamin D Receptor, 9 X if also had previous miscarriage – June 2017 15 Jun, 2017
Infants have low levels of vitamin D – associations with phototherapy and miscarriage – Dec 2016 01 Jan, 2017
Infants have low vitamin D levels in infants – association with phototherapy and miscarriage – Dec 2016 01 Jan, 2017
Recurrent miscarriage associated with half as much vitamin D getting to fetus – Sept 2016 07 Aug, 2016
Abortion 3X higher risk if very low vitamin D – Jan 2016 12 Jun, 2016
Miscarriage 3X more often if very low vitamin D – Jan 2016 12 Jun, 2016
Miscarriage in 2nd trimester associated with low vitamin D – July 2012 07 Sep, 2015

VitaminDWiki - Low Vitamin D is worse for your health than smoking

10+ VitaminDWiki Pregnancy pages have SMOKING in the title

This list is automatically updated

Items found: 11

VitaminDWiki - Vitamin D Receptor

The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators

Resveratrol improves health (Vitamin D receptor, etc.) has the following

  • The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
  • Resveratrol is one of 14+ ways to negate the Vitamin D Receptor restrictions
  • Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi
  • Benefits of Resveratrol, like Vitamin D, appear to be increased when used with other things
    • Quercetin and Curcumin in the case of Resveratrol
18 articles in both of the categories Resveratrol and Vitamin D Receptor

Vitamin D Receptor category has the following

517 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 47 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

How to increase VDR activation

Compensate for poor VDR by increasing one or more:

1) Vitamin D supplement  Sun
Ultraviolet -B
Vitamin D in the blood
and thus in the cells
2) MagnesiumVitamin D in the blood
 AND in the cells
3) Omega-3 Vitamin D in the cells
4) Resveratrol Vitamin D Receptor
5) Intense exercise Vitamin D Receptor
6) Get prescription for VDR activator
   paricalcitol, maxacalcitol?
Vitamin D Receptor
7) Quercetin (flavonoid) Vitamin D Receptor
8) Zinc is in the VDRVitamin D Receptor
9) BoronVitamin D Receptor ?,
10) Essential oils e.g. ginger, curcuminVitamin D Receptor
11) ProgesteroneVitamin D Receptor
12) Infrequent high concentration Vitamin D
Increases the concentration gradient
Vitamin D Receptor
13) Sulfroaphane and perhaps sulfurVitamin D Receptor
14) Butyrate especially gutVitamin D Receptor
15) BerberineVitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

There are, of course, many non-vitamin D causes of miscarriage


Investigating the etiology of recurrent pregnancy loss (vitamin D not mentioned) - May 2023

MD Edge

  • "Although early first-trimester miscarriage is common, occurring in approximately 15% of clinically recognized pregnancies, only 2%-3% of couples experience two or more miscarriages and 0.5%-1% experience three or more."

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Attached files

ID Name Comment Uploaded Size Downloads
16790 Wikipediaf_recurrent_miscarriage.png admin 24 Dec, 2021 312.36 Kb 554
16789 miscarriage.pdf admin 24 Dec, 2021 1.62 Mb 305