Toggle Health Problems and D

Respiratory infection, children and Vitamin D - many studies

23+ VitaminDWiki Infant-Child pages with RESPIRATORY OR RTI in title

This list is automatically updated

Items found: 25
Title Modified
2X less risk of respiratory distress syndrome if 50,000 IU of Vitamin D just before premature birth – RCT May 2024 18 May, 2024
COVID Vaccinated Children 1.25 X More Likely to Be Hospitalized for Respiratory Illness - CDC Jan 2024 12 Jan, 2024
Respiratory infection, children and Vitamin D - many studies 08 Oct, 2023
Respiratory infections in children 6 X more likely if low Vitamin D (avg of 2 studies) - Aug 2023 22 Aug, 2023
3% fewer respiratory problems in children if single 100K vitamin D in 3rd trimester – May 2023 27 May, 2023
Cost-effective to give Vitamin D to all children to prevent acute respiratory infection – April 2023 09 Apr, 2023
Respiratory viral infection (RSV) and low vitamin D - many studies 18 Nov, 2022
2.4 X fewer lower respiratory track infections in infants getting 400 IU of Vitamin D – May 2022 24 May, 2022
Infant Respiratory Infections not reduced by mothers taking small amount of vitamin D (28,000 weekly)– RCT July 2021 03 Jul, 2021
Recurrent RTI treatment success: Conventional 71 pcnt, Vitamin D 96 pcnt – March 2021 12 Apr, 2021
Preemie Respiratory Distress Syndrome is 5X more likely if low vitamin D – Dec 2020 18 Dec, 2020
Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020 07 Mar, 2020
No preemie had even 30 ng of vitamin D, lower D associated with more Respiratory Distress – Aug 2013 24 Jul, 2019
Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019 15 Feb, 2019
Childhood Respiratory Health hardly improved with 600 IU of vitamin D (need much more) – May 2018 28 May, 2018
Preemies with poor lungs (Respiratory distress syndrome) have low levels of vitamin D – Nov 2017 14 Nov, 2017
Respiratory infection in infant was 7 X more likely if low cord Vitamin D – March 2017 28 Sep, 2017
Acute Lower Respiratory Infections in Children - associated with low vitamin D – meta-analysis Dec 2014 16 Sep, 2016
Respiratory tract infections in childhood – vitamin D is needed, no consensus of how much – Oct 2015 15 May, 2016
Respiratory distress after preterm birth is more likely if low vitamin D – review April 2015 05 Aug, 2015
Low dose Vitamin D during pregnancy and infancy results in strange acute respiratory infection response – April 2015 24 Mar, 2015
Acute lower respiratory infection 5X more frequent with low vitamin D intake – June 2012 20 Mar, 2015
Newborn acute lower respiratory tract infection associated with low maternal vitamin D – March 2015 20 Mar, 2015
Respiratory Tract Infection visits 2.5 less likely with vitamin D: Pregnancy 2000 IU, Infant 800 IU – RCT Oct 2014 04 Oct, 2014
Largest cause of infant deaths is respiratory infections, which is associated with low vitamin D – April 2011 23 Jun, 2013

RTI Meta-analysis failed to look at any Vitamin D dosing >2,000 IU - July 2023

A meta-analysis of the association between vitamin D supplementation and the risk of acute respiratory tract infection in the healthy pediatric group
Front Nutr. 2023 Jun 20;10:1188958. doi: 10.3389/fnut.2023.1188958. eCollection 2023.
 Download the PDF from VitaminDWiki

Acute respiratory infections decreased a small amount when a small amount of vitamin D was added – meta-analysis March 2020

Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials
Lancet Diabetes and Endocrinology March 30, 2021DOI:https://doi.org/10.1016/S2213-8587(21)00051-6
David A Jolliffe, PhD, Prof Carlos A Camargo Jr, MD, John D Sluyter, PhD, Mary Aglipay, Msc, Prof John F Aloia, MD, Davaasambuu Ganmaa, PhD

A 2017 meta-analysis of data from 25 randomised controlled trials (RCTs) of vitamin D supplementation for the prevention of acute respiratory infections (ARIs) revealed a protective effect of this intervention. We aimed to examine the link between vitamin D supplementation and prevention of ARIs in an updated meta-analysis.

For this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, Web of Science, and the ClinicalTrials.gov registry for studies listed from database inception to May 1, 2020. Double-blind RCTs of vitamin D3, vitamin D2, or 25-hydroxyvitamin D (25[OH]D) supplementation for any duration, with a placebo or low-dose vitamin D control, were eligible if they had been approved by a research ethics committee, and if ARI incidence was collected prospectively and prespecified as an efficacy outcome. Studies reporting results of long-term follow-up of primary RCTs were excluded. Aggregated study-level data, stratified by baseline 25(OH)D concentration and age, were obtained from study authors. Using the proportion of participants in each trial who had one or more ARIs, we did a random-effects meta-analysis to obtain pooled odds ratios (ORs) and 95% CIs to estimate the effect of vitamin D supplementation on the risk of having one or more ARIs (primary outcome) compared with placebo. Subgroup analyses were done to estimate whether the effects of vitamin D supplementation on the risk of ARI varied according to baseline 25(OH)D concentration (<25 nmol/L vs 25·0–49·9 nmol/L vs 50·0–74·9 nmol/L vs >75·0 nmol/L), vitamin D dose (daily equivalent of <400 international units [IU] vs 400–1000 IU vs 1001–2000 IU vs >2000 IU), dosing frequency (daily vs weekly vs once per month to once every 3 months), trial duration (≤12 months vs >12 months), age at enrolment (<1·00 years vs 1·00–15·99 years vs 16·00–64·99 years vs ≥65·00 years), and presence versus absence of airway disease (ie, asthma only, COPD only, or unrestricted). Risk of bias was assessed with the Cochrane Collaboration Risk of Bias Tool. The study was registered with PROSPERO, CRD42020190633.

We identified 1528 articles, of which 46 RCTs (75 541 participants) were eligible. Data for the primary outcome were obtained for 48 488 (98·1%) of 49 419 participants (aged 0–95 years) in 43 studies. A significantly lower proportion of participants in the vitamin D supplementation group had one or more ARIs (14 332 [61·3%] of 23 364 participants) than in the placebo group (14 217 [62·3%] of 22 802 participants), with an OR of 0·92 (95% CI 0·86–0·99; 37 studies; I2=35·6%, pheterogeneity=0·018). No significant effect of vitamin D supplementation on the risk of having one or more ARIs was observed for any of the subgroups defined by baseline 25(OH)D concentration. However, protective effects of supplementation were observed in trials in which vitamin D was given in a daily dosing regimen (OR 0·78 [95% CI 0·65–0·94]; 19 studies; I2=53·5%, pheterogeneity=0·003), at daily dose equivalents of 400–1000 IU (0·70 [0·55–0·89]; ten studies; I2=31·2%, pheterogeneity=0·16), for a duration of 12 months or less (0·82 [0·72–0·93]; 29 studies; I2=38·1%, pheterogeneity=0·021), and to participants aged 1·00–15·99 years at enrolment (0·71 [0·57–0·90]; 15 studies; I2=46·0%, pheterogeneity=0·027). No significant interaction between allocation to the vitamin D supplementation group versus the placebo group and dose, dose frequency, study duration, or age was observed. In addition, no significant difference in the proportion of participants who had at least one serious adverse event in the vitamin supplementation group compared with the placebo group was observed (0·97 [0·86–1·07]; 36 studies; I2=0·0%, pheterogeneity=0·99). Risk of bias within individual studies was assessed as being low for all but three trials.

Despite evidence of significant heterogeneity across trials, vitamin D supplementation was safe and overall reduced the risk of ARI compared with placebo, although the risk reduction was small. Protection was associated with administration of daily doses of 400–1000 IU for up to 12 months, and age at enrolment of 1·00–15·99 years. The relevance of these findings to COVID-19 is not known and requires further investigation.
 Download the PDF from VitaminDWiki

There have been 79943 visits to this page

Attached files

ID Name Comment Uploaded Size Downloads
19997 RTI Child Meta.pdf admin 22 Aug, 2023 473.26 Kb 110
19756 acute respiratory meta.pdf admin 06 Jul, 2023 1.18 Mb 142
19755 RTI 2,000 IU max.jpg admin 06 Jul, 2023 42.98 Kb 237