Vitamin D is the best Vitamin to prevent a stroke - meta-analysis Jan 2024

From A to E: Uniting vitamins against stroke risk-A systematic review and network meta-analysis

Eur J Clin Invest. 2024 Jan 30:e14165. doi: 10.1111/eci.14165
Shashank Tripathi 1, Manabesh Nath 1, Shubham Misra 2, Pradeep Kumar 3

Background and aim: Stroke represents a significant public health challenge, necessitating the exploration of preventive measures. This network meta-analysis aimed to assess the efficacy of different vitamin treatments compared to a placebo in preventing stroke.

Methods: A systematic electronic search in databases including PubMed, EmBASE, Web of Science, clinicaltrials.gov, and Google Scholar until 31 May 2023 was conducted, to identify published studies investigating the association between vitamin intake and the risk of stroke. Pooled risk ratio (RR) with 95% confidence intervals (CIs) was calculated using a frequentist network meta-analysis. Furthermore, we ranked vitamins based on p-scores, facilitating a comparative assessment of their effectiveness in preventing stroke.

Results: A total of 56 studies, including

  • 17 randomized controlled trials (RCTs) and
  • 39 cohort studies were analyzed.

Direct estimates obtained from network meta-analysis, we found that vitamin A (RR: .81 [.72-.91]), vitamin B-complex (RR: .85 [.74-.97]), vitamin B6 (RR: 79 [.68-.92]), folate (RR: .86 [.75-.97]), vitamin C (RR: .77 [.70-.85]) and vitamin D (RR: .73 [.64-.83]) were significantly associated with a decreased stroke risk. However, no significant association was observed for vitamin B2 , vitamin B12 , and vitamin E.
Subsequent to network meta-analysis, vitamins were ranked in decreasing order of their efficacy in stroke prevention based on p-score, with

  1. Vitamin D (p-score = .91),
  2. vitamin C (p-score = .79),
  3. vitamin B6 (p-score = .70),
  4. vitamin A (p-score = .65),
  5. vitamin B-complex (p-score = .53),
  6. folate (p-score = .49),
  7. vitamin B2 (p-score = .39),
  8. vitamin E (p-score = .28),
  9. vitamin B12 (.13) and
  10. pacebo (.10).

Conclusion: Our study has established noteworthy connections between vitamin A, vitamin B-complex, vitamin B6 , folate, vitamin C, and vitamin D in the realm of stroke prevention. These findings add substantial weight to the accumulating evidence supporting the potential advantages of vitamin interventions in mitigating the risk of stroke. However, to solidify and validate these observations, additional research is imperative. Well-designed clinical trials or cohort studies are needed to further explore these associations and formulate clear guidelines for incorporating vitamin supplementation into effective stroke prevention strategies.

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VitaminDWiki – Stroke category contains

131 items in stroke category - see also Overview Stroke and vitamin D,
Overview Hypertension and Vitamin D  Overview Cardiovascular and vitamin D

Stroke more likely if low Vitamin D

Post-Stroke worse if low Vitamin D

Post-Stroke better if add Vitamin D

Post-Stroke better if Vitamin D actually gets to cells

11 studies in both categories of Depression and Stroke

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VitaminDWiki - 10 Stroke Meta-analyses

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6+ VitaminDWiki Stroke pages have PREVENT in the title

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Items found: 7


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