Table of contents
- Impact of n-3 polyunsaturated fatty acid intake in pregnancy on maternal health and birth outcomes: systematic review and meta-analysis from randomized controlled trails
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40 studies in both categories Pregnancies and Omega-3
Impact of n-3 polyunsaturated fatty acid intake in pregnancy on maternal health and birth outcomes: systematic review and meta-analysis from randomized controlled trails
Arch Gynecol Obstet. 2022 Mar 28. doi: 10.1007/s00404-022-06533-0 PDF costs $40 read for free on DeepDyve
Mona A Abdelrahman 1, Hasnaa Osama 2, Haitham Saeed 2, Yasmin M Madney 2, Hadeer S Harb 2, Mohamed E A Abdelrahim 2Background: Maternal omega-3 consumption during pregnancy has been positively linked with a positive impact on maternal health and fetal growth. However, the results of individual studies are inconsistent and conflicting.
Objective: Examine the effect of supplementation with DHA, and/or EPA, and/or ALA throughout pregnancy on offspring's growth and pregnancy outcomes.
Design: A systematic review and meta-analysis.
Population: Pregnant women.
Methods: According to (PRISMA) statement and the Cochrane Handbook guidelines. Human trials (RCT or quasi-RCT) which involved oral omega-3 supplementation at least twice a week during pregnancy were included and comparing it with control groups with no supplementation or placebo administration. Data were extracted and directed using RevMan software. Fifty-nine randomized controlled trials were eligible for inclusion in the meta-analysis. Performed in MEDLINE, PubMed, Scopus, Google Scholar, and the Cochrane Library comparing omega 3 with control groups, from 1990 to 2020.
The main outcome measures: The primary outcome measures were pregnancy-induced hypertension, preeclampsia, gestational duration, preterm birth, early preterm birth, birth weight, low birth weight, neonatal length, and head circumference. The secondary outcomes were neonatal intensive care unit, infant death, prenatal death, and cesarean section.
Results: In 24 comparisons (21,919 women) n-3 fatty acids played a protective role against the risk of- preeclampsia (RR = 0.84, 95% CI 0.74-0.96 p = 0.008; I2 = 24%).
In 46 comparisons (16,254 women) n-3 fatty acids were associated with a significantly
- greater duration of pregnancy (MD = 1.35, 95% CI 0.65-2.05, p = 0.0002; I2 = 59%).
27 comparisons (15,510 women) was accompanied by a significant decrease in
- pre-term birth less than 37 weeks (RR = 0.86, 95% CI 0.77-0.95, p = 0.005; I2 = 0%).
12 comparisons (11,774 women) was accompanied by a significant decrease in
- early pre-term birth less than 34 weeks (RR = 0.77, 95% CI 0.63-0.95, p = 0.01; I2 = 40%).
38 comparisons (16,505 infants) had a significant- increase in birth weight (MD = 49.19, 95% CI 28.47-69.91, p < 0.00001; I2 = 100%).
Finally, 14 comparisons (8,449 infants) had a borderline significance in
- increase in low birth weight (RR = 0.88, 95% CI 0.78-1.00, p = 0.05; I2 = 28%).
Conclusions: Supplementation with omega-3 in prgnancy can prevent preeclampsia, increase gestational duration, increase birth weight and decrease the risk of low birth weight and preterm birth.
Secondary outcomes
Risk of admission to the neonatal intensive care unit (13 trials)
Incidence of cesarean delivery (29 trials)
Prenatal death (12 trials)
Infant death (10 trials)
VitaminDWiki - Omega-3 helps many health problems
394 Omega-3 items in category Omega-3 helps with: Autism ( 8 studies), Depression ( 29 studies), Cardiovascular ( 34 studies), Cognition ( 49 studies), Pregnancy ( 40 studies), Infant ( 32 studies), Obesity ( 13 studies), Mortality ( 7 studies), Breast Cancer ( 5 studies), Smoking, Sleep, Stroke, Longevity, Trauma ( 12 studies), Inflammation ( 18 studies), Multiple Sclerosis ( 9 studies), VIRUS ( 12 studies), etc
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40 studies in both categories Pregnancies and Omega-3 This list is automatically updated
- Stillbirth reduced by Vitamin D, Zinc, Omega-3 - several studies
- Preterm birth decreased by Omege-3, etc. - many studies
- Preterm birth reduction by nutrients - Vitamin D is the best, Omega-3 is next best – May 2022
- Omega-3 improves pregnancies – Meta-analysis May 2022
- Omega-3 supplementation reduced preterm birth rate by 4X – RCT July 2020
- Conception 1.5 X more likely if taking any amount of Omega-3 – Feb 2022
- Pre-term birth rate cut in half with 1000 milligrams of Omega-3 (if initially low) – RCT May 2021
- Omega-3 recommended in Australia during pregnancy - April 2021
- Pregnancy recommendations – huge differences in Vitamin D, Mg, iron, Iodine, DHA, etc – April 2021
- Seafood (Omega-3) during pregnancy increased childhood IQ by 8 points – review Dec 2019
- Pregnant women in Australia to take Omega-3 when told of reduction in preterm births – Dec 2019
- Fat-soluble vitamins critical for conception, pregnancy and breast feeding (pigs) – Sept 2019
- Preterm Births reduced by Omega-3, Zinc, and Vitamin D – Aug 2019
- Depression after childbirth 5 X less likely if good Omega-3 index – April 2019
- Infant Problem-Solving Skills Linked to Mother’s DHA Omega-3 Level During Pregnancy – April 2019
- Omega-3 during pregnancy and breastfeeding is recommended – May 2019
- Preterm Births decreased by Omega-3 (analysis of 184 countries) – April 2019
- Preterm Births - promising preventions – anti-oxidants, Vitamin D, Omega-3, Zinc, etc. – Jan 2019
- Preterm birth might be prevented by Vitamin D, Omega-3, etc. (International survey) – Jan 2019
- Omega-3 index of 5 greatly decreases the risk of an early preterm birth – Dec 2018
- Omega-3 added during pregnancy helps in many ways – Cochrane Review of RCTs Nov 2018
- Omega-3 helps conception as well as pregnancy – many studies
- More pregnancies and fewer abortions when Omega-3 was added (cows in this case) July 2018
- PCOS treated by a combination of Vitamin D and Omega-3 – RCT Oct 2018
- Omega-3 – fewer than 5 percent of adult women get the RDA – April 2018
- Omega-3, Vitamin D, Folic acid etc. during pregnancy and subsequent mental illness of child – March 2018
- Supplementation while pregnant and psychotic – 20 percent Omega-3, 6 percent Vitamin D – June 2016
- Importance of Vitamin D and fish rarely mentioned during midwife-led prenatal booking visits – July 2017
- Preterm birth rate of pregnant smokers cut in half if take Omega-3 – RCT May 2017
- Gestational diabetes treated by Vitamin D plus Omega-3 – RCT Feb 2017
- Asthma reduced 31 percent when Omega-3 taken during pregnancy – RCT Dec 2016
- Preterm births strongly related to Vitamin D, Vitamin D Receptor, Iodine, Omega-3, etc
- Typical pregnancy is now 39 weeks – Omega-3 and Vitamin D might restore it to full 40 weeks
- Omega-3 supplementation during pregnancy reduce early preterm births (save 1500 USD per child) – Aug 2016
- Rancid Omega-3 increased the odds of newborn mortality by 13 times (rats) – July 2016
- Preterm birth extended by 2 weeks with Omega-3 – Meta-analysis Nov 2015
- Stillbirth rate typically 1 in 200, perhaps only 1 in 800 with Omega-3
- Omega-3 helps pregnancy in many ways: preterm 26 percent less likely etc – review July 2012
- Pregnancy and infants healthier with Omega-3 supplementation - many studies
- Vitamin D, DHA, Folic, Iodine benefits during pregnancy – July 2012
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