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Alopecia areata (spot baldness) associated with 8.5 ng lower levels of vitamin D – meta-analysis April 2018

Increased prevalence of vitamin D deficiency in patients with alopecia areata: A systematic review and meta‐analysis

Journal of the European Academy Dermology and Venereology 6 April 2018, https://doi.org/10.1111/jdv.14987
S Lee B J Kim C H Lee W S Lee






  • Alopecia areata Wikipedia
    “Alopecia areata, also known as spot baldness, is a condition in which hair is lost from some or all areas of the body. Often it results in a few bald spots on the scalp, each about the size of a coin”
    “Alopecia areata is believed to be an autoimmune disease. Risk factors include a family history of the condition. Among identical twins if one is affected the other has about a 50% chance of also being affected”
    “There is no cure for the condition.”
    “The condition affects 0.1%–0.2% of the population”

 Download the PDF from Sci-Hub via VitaminDWiki

Alopecia areata (AA) is a hair follicle‐specific autoimmune disorder. Vitamin D deficiency has been associated with various autoimmune disorders for its immunomodulatory effects. However, in previous studies, there had been inconsistent association found between AA and vitamin D deficiency.

Objective: To demonstrate the differences of the mean serum 25‐hydroxyvitamin D level and prevalence of vitamin D deficiency between AA subjects and non‐AA controls.

Methods: A systematic review and meta‐analysis of observational studies on AA and serum vitamin D levels and/or prevalence of vitamin D deficiency was performed searching MEDLINE, Cochrane, Web of Science, and Google Scholar databases.

In all, 14 studies including a total of 1,255 AA subjects and 784 non‐AA control were analyzed. The mean serum 25‐hydroxyvitamin D level was significantly lower in AA subjects (‐8.52 ng/dL; 95% confidential interval; ‐5.50 to ‐11.53). The subjects with AA had higher odds of vitamin D deficiency of vitamin D deficiency (odds of 3.55; 2.03 to 6.20, mean prevalence of 75.5%; 60.8 to 86.0%). However, it was difficult to find clear correlation between serum 25‐hydroxyvtamin D level and extent of hair loss in AA.

The AA subjects had lower serum 25‐hydroxyvitamin D level and vitamin D deficiency was highly prevalent compared to non‐AA controls. Hence, Vitamin D deficiency should be assessed in AA patients. Furthermore, nutritional supplementation of vitamin D or topical vitamin D analogues can be considered for AA patients with vitamin D deficiency. The limitation of this study is the highly heterogeneity of the included studies.

Created by admin. Last Modification: Tuesday December 24, 2019 16:36:23 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
9727 AA4.jpg admin 17 Apr, 2018 9.60 Kb 3468
9726 AA3.jpg admin 17 Apr, 2018 6.08 Kb 20356
9725 AA2.jpg admin 17 Apr, 2018 8.93 Kb 5823
9724 AA Wikipedia.jpg admin 17 Apr, 2018 16.36 Kb 8036
9723 AA figure B.jpg admin 17 Apr, 2018 56.56 Kb 7587
9722 Alopecia areata.pdf admin 17 Apr, 2018 803.30 Kb 788