- Summary of many studies of Vitamin D and organ transplantation
- 33+ VitaminDWiki pages have TRANSPLANT (not FECAL) in the title
- Vitamin D in organ transplantation - 2011
- Survive heart transplant better if have more vitamin D
- Immune system is often supressed so that a new organ can be accepted by the body
But, the immune syetem is needed to avoid COVID-19 - See also web
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15842 visits to this page
Summary of many studies of Vitamin D and organ transplantation
More vitamin D needed especially needed if organ = liver or kidney (low vitamin d ==> poor bones)
Both regular and active vitamin D have been used
Supplementation can be oral, injection, etc
Extra Vitamin D can be before or after the surgery
Problems avoided include: infection, rejection, death
33+ VitaminDWiki pages have TRANSPLANT (not FECAL) in the title
Items found: 32
Vitamin D in organ transplantation - 2011
Osteoporos Int. 2011 Jan 5.
Stein EM, Shane E.
Department of Medicine, Columbia University Medical Center, 630 West 168th Street, PH8-864, New York, NY, 10032, USA, es2029 at columbia.edu.Vitamin D deficiency is prevalent among patients with end-stage organ failure awaiting transplant. Low serum 25-hydroxyvitamin D (25-OHD) levels in these patients may be related to many disease-specific factors, as well as decreased sunlight exposure and limited intake of foods containing vitamin D.
Low serum 25-OHD levels are also extremely common following solid organ transplantation, both during the immediate postoperative period and in long-term graft recipients.
Demographic and lifestyle factors are important in determining D status in transplant recipients.
Worse vitamin D status is associated with poorer general health, lower albumin, and even decreased survival among these patients.
Although several studies have demonstrated that active forms of vitamin D and its analogues prevent bone loss following transplantation, the data do not show consistent benefit.
These therapies may have particular utility after renal transplantation. However, given the narrow therapeutic window with respect to hypercalcemia and hypercalciuria, and the demonstrated efficacy of bisphosphonates to prevent post-transplantation bone loss, we regard these agents as adjunctive rather than primary therapy for transplantation osteoporosis.
The effects of 1,25(OH)(2)D on the immune system, which are still being elucidated, may have potential for reducing infections and preventing allograft rejection after transplantation. PMID: 21207011
Cited by 70 later studes as of March 2021
- Vitamin D Receptor Activity, Vitamin D Status, and Development of De-novo Donor-specific Antibody after Renal Transplantation - March 2020
Survive heart transplant better if have more vitamin D
PDF is attached at the bottom of this page
Immune system is often supressed so that a new organ can be accepted by the body
But, the immune syetem is needed to avoid COVID-19- immunosuppressants National Kidney Foundation
- COVID-19: Issues related to solid organ transplantation Feb 2021
- 'It's Kind of a Catch-22': Immunosuppression and COVID-19 Vaccines MedPageToday, March 23, 2021
- "A recent study found fewer than 20% of solid organ transplant patients mounted detectable antibodies to SARS-CoV-2 following a first dose of COVID-19 vaccine, raising questions about vaccine protection in this population compared to immunocompetent people."
- "Now in transplant patients, what we found is that only 17% have detectable antibody after dose one. "
- 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
- Includes immunosuppression as a risk factor
- General Approach to the Clinical Care of Solid Organ Transplant Recipients with COVID-19 Infection: Management for Transplant Recipients - Oct 2020  PDF
See also web
- Clinical Trials: Transplant and Vitamin D 109 listed as of Nov 2023
- Low Vitamin D Exposure is Associated with Higher Risk of Infection in Renal Transplant Recipients March 2017
-  Download the PDF from Sci-hub via VitaminDWiki
43% fewer infections within 90 days if Vitamin D > 30 ng
"Transplant patients with low calcidiol levels have an increased risk of
metabolic and endocrine problems,
cardiovascular disease,
type 2 diabetes mellitus,
poor graft survival,
bone disorders,
cancer, and
mortality rate."
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15842 visits to this page Vitamin D helps organ transplant - many studies6547 visitors, last modified 28 Oct, 2024, This page is in the following categories (# of items in each category)Attached files
ID Name Uploaded Size Downloads 15309 Transplant Oct 2020.pdf admin 24 Mar, 2021 514.38 Kb 302 15308 Renal Transplantation March 2020.pdf admin 24 Mar, 2021 293.80 Kb 321 15307 Kidney transplant 2017.pdf admin 24 Mar, 2021 524.95 Kb 309 1887 Heart Transplant survival vs calcitriol.jpg admin 28 Dec, 2012 24.26 Kb 1715 1886 Vitamin D in organ transplantation.pdf admin 28 Dec, 2012 326.33 Kb 882
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