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276,000 IU of Vitamin D daily was too much – April 2021

Vitamin D intoxication in patients with cystic fibrosis: report of a single-center cohort

Scientific Reports | (2021) 11:7719 https://doi.org/10.1038/s41598-021-87099-w
Thomas Plante-Bordeneuve1, Silvia Berardis2,5, Pierre Bastin, Damien Gruson3, Laurence Henri, & Sophie Gohy1,5*

Patients accidentally getting the extremely high doses got average vitamin D levels of 185 ng

Vitamin D toxicity is associated with accidental overdoses due to manufacturing or intake errors and its secondary hypercalcemia can result in severe morbidity. Although patients with cystic fibrosis are potentially at increased risk for this intoxication as prescription of vitamin D preparations is a common practice in this population, the frequency of such events is currently unknown. We performed a retrospective analysis of all the files of cystic fibrosis patients followed at the Cliniques universitaires Saint-Luc over a 10-year period, recording 25(OH)- and 1,25(OH)2 vitamin D levels as well as demographic data, lung function tests, Pseudomonas aeruginosa infection and results from pharmacological analysis of magistral liposoluble vitamins preparations. A total of 244 patients were included in the study. 13 patients (5%) had serum vitamin D levels corresponding to vitamin D overdose. Patients who had experienced an overdose were more likely to be F508del homozygous or suffer from exocrine pancreatic insufficiency. 2 patients developed significant hypercalcemia necessitating monitoring and hospitalization. Errors in the preparation of magistral liposoluble vitamin pills were identified in several intoxicated patients. Retrospective assessment of the dosing errors with the local pharmacists showed that trituration and dosing errors were their most frequent causes.

Deep inside the PDF

  • In our population, the median prescribed dose of 4000UI of D3 could not explain the observed 25(OH)D levels, and further analysis of the available vitamin D concentrations contained in the compounded prescribed pills revealed that patients were taking a median 69 times the prescribed dosage. “

Note: Many US companies send every batch of Vitamin D out for independent checking of dose size and contaminates
Example companies include: Bio-Tech Pharmacal and BioinnovationsPharmacal. both of which are on Amazon

Overview Toxicity of vitamin D has the following chart

Graph of dose vs week

Created by admin. Last Modification: Tuesday May 18, 2021 17:52:45 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
15597 Vit D toxicity, phama error, cystic fibrosis Plante-Bordeneuve.pdf PDF 2021 admin 18 May, 2021 17:15 826.59 Kb 133