Table of contents
- Post-Diagnosis Vitamin D Supplement Use and Survival among Cancer Patients: A Meta-Analysis
- 13% fewer deaths (most the of RCT provided a paltry <2,000 IU of vitamin D)
- VitaminDWiki – Cancer - After diagnosis category contains
- After Cancer Diagnosis and Intervention
8 studies - Cancer - after diagnosis pages containing CHEMO in title (31 as of Oct 2021)
- A poor Vitamin D receptor is assocated with Cancer in 74 titles as of Aug 2022
Post-Diagnosis Vitamin D Supplement Use and Survival among Cancer Patients: A Meta-Analysis
Nutrients 2022, 14(16), 3418; https://doi.org/10.3390/nu14163418
Vitamin D administered pre-diagnostically has been shown to reduce mortality. Emerging evidence suggests a role of post-diagnosis vitamin D supplement intake for survival among cancer patients. Thus, we conducted a meta-analysis to evaluate the relationship. PubMed and Embase were searched for relevant observational cohort studies and randomized trials published through April 2022. Summary relative risk (SRR) and 95% confidence interval (CI) were estimated using the DerSimonian–Laird random-effects model.
The SRR for post-diagnosis vitamin D supplement use vs. non-use, pooling cohort studies and randomized trials, was- 0.87 (95% CI, 0.78–0.98; p = 0.02; I2 = 0%) for overall survival,
- 0.81 (95% CI, 0.62–1.06; p = 0.12; I2 = 51%) for progression-free survival,
- 0.86 (95% CI, 0.72–1.03; p = 0.10; I2 = 0%) for cancer-specific survival, and
- 0.86 (95% CI, 0.64–1.14; p = 0.29; I2 = 0%) for relapse.
Albeit not significantly heterogeneous by variables tested, a significant inverse association was limited to cohort studies and supplement use during cancer treatment for overall survival, and to studies with ≤3 years of follow-up for progression-free survival. Post-diagnosis vitamin D supplement use was associated with improved overall survival, but not progression-free or cancer-specific survival or relapse. Our findings require confirmation, as randomized trial evidence was insufficient to establish cause-and-effect relationships.
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13% fewer deaths (most the of RCT provided a paltry <2,000 IU of vitamin D)
VitaminDWiki would expect a 30% reduction in deaths if reasonable loading and maintenace doses were to be used
VitaminDWiki – Cancer - After diagnosis category contains
- Most cancers reduce vitamin D levels
- Most cancer treatments (chemo, radiation) further lower Vitamin D
- Higher levels of vitamin D minimize many side-effects of cancer therapy
- High levels of vitamin D augment many chemotherapies
- High levels of vitamin D augment cancer immunotherapies
- High levels of vitamin D can kill some cancer cells 1,720 items 12/2023
- Some cancers deactivate the vitamin D receptor
Example VitaminDWiki Studies
- Cancer and Vitamin D - many studies
- Easiest way to treat cancer – take Vitamin D – Nov 2022
- Even after a Cancer diagnosis Vitamin D improves survival – meta-analysis Aug 2022
- Vitamin D is synergistic with many Cancer therapies (radiation in this case) – Aug 2021
- Vitamin D prevents and treats cancer in many ways – May 2021
- Cancer patients need more vitamin D, even those who are supplementing – observational study June 2021
- Metastatic Cancer probably reduced by vitamin D - many studies
- Colorectal Cancer treatment aided by omega-3 plus weekly Vitamin D – RCT Sept 2019
- Radiation therapy, used to treat some cancers, causes less damage if use Vitamin D (or Melatonin) – Aug 2022
- Vitamin D is synergistic with many Cancer therapies (radiation in this case) – Aug 2021
- Vitamin D prevents and treats cancer in many ways – May 2021
- Palliative care is helped by Vitamin D - many studies
- 4X less of one chemo needed after vitamin D receptor activation - June 2020
Breast Cancer
- Breast Cancer survivors with high vitamin D were 3.3 X less likely to have metastases – May 2023
- Breast Cancer survival: 44% with just 10,000 IU of vitamin D per week, 33% with placebo – RCT Dec 2023
- Breast cancer recurred twice as often if have less than 20 ng of vitamin D – Dec 2018
- Breast Cancer chemotherapy 2.7 X more likely to be successful if not vitamin D deficient – Dec 2017
After Cancer Diagnosis and Intervention
8 studies - Breast Cancer survival: 44% with just 10,000 IU of vitamin D per week, 33% with placebo – RCT Dec 2023
- Breast Cancer chemo reduces Bone Mineral Density, injecting Vitamin D increases it – Sept 2019
- Colorectal Cancer treatment aided by omega-3 plus weekly Vitamin D – RCT Sept 2019
- Digestive tract cancer death rates reduced a bit by a bit of vitamin D – RCT April 2019
- Breast Cancer trial using 50,000 IU Vitamin D weekly cancelled (no funding)
- Palliative cancer benefit of 4,000 IU of Vitamin D – less opioids, infection, and CRP – Aug 2017
- Breast Cancer medicine pain reduced with 4300 IU vitamin D – RCT June 2012
- Active form of vitamin D appears to help prevent and treat some cancers – Feb 2011
Cancer - after diagnosis pages containing CHEMO in title (31 as of Oct 2021)
This list is automatically updated
A poor Vitamin D receptor is assocated with Cancer in 74 titles as of Aug 2022
Note: Some Cancers protect themselves by deactivating the VDR
This list is automatically updated
Even after a Cancer diagnosis Vitamin D improves survival – meta-analysis Aug 2022Printer Friendly Follow this page for updates1180 visitors, last modified 13 Dec, 2023, This page is in the following categories (# of items in each category)