Vertigo incidence reduced 40% by just 7,000 IU Vitamin D given weekly - RCT Feb 2024

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Vitamin D supplementation in preventing the recurrence of benign paroxysmal positional vertigo

Tae Hoon Kong MD, PhD, Su Young Jung MD, Young Joon Seo MD, PhD, Dae Bo Shim MD, PhD
Investigative Otorhinolaryngology February 2024 https://doi.org/10.1002/lio2.1225

Objective
To evaluate the effect of vitamin D supplementation on the recurrence rate of benign paroxysmal positional vertigo (BPPV).

Methods
A single-center, prospective, double-blind, placebo-controlled, parallel-group randomized controlled trial was conducted between November 2018 and May 2020. After successful treatment with canalith repositioning maneuvers, patients diagnosed with BPPV were randomized to either the vitamin D (n = 20) or placebo (n = 18) group. Only patients with serum vitamin D levels <20 ng mL−1 were included. The vitamin D group received 7000 IU of vitamin D weekly for a year, while the placebo group received a matching placebo drug. The final endpoint was the BPPV recurrence rate and correlation with serum vitamin D levels after 6 and 12 months in both groups.

Results
Among 38 patients, 37 were followed up for 6 months and 30 for 12 months. Significantly higher serum vitamin D levels were observed in the vitamin D group compared to the placebo group at both the 6-month and 1-year follow-ups (p < .001 at each timepoint). The recurrence rate was lower in the vitamin D group than in the placebo group after 6 months (p = .008) and 1 year (p = .003).

Conclusion
Vitamin D supplementation, in the absence of calcium, may be beneficial for patients prone to recurrent BPPV episodes, particularly when serum vitamin D levels are suboptimal (PRE20181024-001, Clinical Research Information Service, South Korea).
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VitaminDWiki - Vertigo treated by Vitamin D - many studies contains

• Vertigo incidence reduced 40% by just 7,000 IU Vitamin D given weekly - RCT Feb 2024
• Common cause of dizziness (BPPV) reduced 5 X by several doses of 50,000 IU of vitamin D – 2015, 2016
• Vertigo (BPPV) much more likely to reoccur if low Vitamin D – Feb 2019
• Overview Fractures and Falls and Vitamin D
• All items in category Falls or Fractures and Vitamin D255 items
• Vitamin D may prevent falls by itself – an overview of 9 meta-analysis – Oct 2012
• Seniors with less than 12 ng of vitamin D were not stable – March 2012
• Overview Magnesium and vitamin D
• Hearing Loss appears to be prevented and treated with vitamin D Hearing loss is strongly associated with Vertigo
• Diseases that may be related via low vitamin D
  • BPPV associated to Osteoporosis could be added due to the first line of the abstract on this page
• Hypothesis: increased bone mineral density needs protein, Ca, Mg, Vitamin D and K
• Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012
• Younger Parkinson’s patients had better balance after 10,000 IU of vitamin D for 16 weeks – RCT Feb 2019
• Vitamin D receptor (TT), which restricts Vit D to cells, is associated with balance problems in seniors – June 2018
• Preventing Falls in Older Adults – Vitamin D combination is the best - JAMA Meta-analysis Nov 2017
• My balance significantly improved at age 73 (perhaps Vitamin D, B12, or Omega-3) – Jan 2020

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VitaminDWiki – Better than Daily contains:

31 items in BETTER THAN DAILY category

Non-daily (Bolus) is better:

1. Better compliance for everyone
   • Fewer opportunities to forget.
   • If happen to forget, just take the pill days or weeks later
   • Fewer times to have to take a pill - for those who dislike doing so
2. Non-daily is better the ~20% who have a poor Vitamin D Receptor
   • A high concentration gradient is one of 14 ways to get past Vitamin D Receptor limitations
   • So, while 80% get no extra benefit from non-daily dosing, 20% will get an extra benefit

• Vitamin D given daily, weekly, or monthly has similar response (116 RCTs) – meta-analysis Aug 2023
• 44 percent of successful RCTs in VitaminDWiki used non-daily dosing - Nov 2020
• Monthly vitamin D dosing better for children than daily (again) - Oct 2023

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220 + VitaminDWiki pages have WEEKLY in the title

This list is automatically updated