Loading...
 
Toggle Health Problems and D

Hip fracture risk was reduced by 4 times when Vitamin D was added to SERMS - Jan 2024

Study: Selective estrogen receptor modulators (SERMs) with vitamin D composite agent can prevent fracture better than SERMs treatment:

based on the National Health Claims Database 2017-2019
Osteoporos Int 2024 Jan 19. doi: 10.1007/s00198-024-07022-7 Can be viewed at DeepDyve 1 month free trial
Seong-Eun Byun 1, Hasung Kim 2, Seung Yun Lee 2, Sang-Min Kim 3

4X reduction in hip fractures in those who happened to be prescribed
to take some amount of Vitamin D in addition to SERMS
Image
With the analysis of nationwide health claim data, treatment with the composite agent of SERMs and vitamin D reduces the risk of osteoporotic fracture and hip fracture better compared to SERMs treatment in women with osteoporosis aged ≥ 50 years.

Purpose: This study compared the potential of the composite agent of selective estrogen receptor modulators (SERMs) and vitamin D (SERM + VitD) with that of SERMs-only for fracture prevention and mortality reduction in women aged ≥ 50 years.

Methods: The incidence of osteoporotic fracture (fractures of the vertebrae, hip, wrist, or humerus) and all-cause death after treatment with SERM + VitD and SERMs were characterized using the Korean National Health Insurance Service database 2017-2019. The participants were divided into two groups (SERM + VitD vs SERMs). After exclusion and propensity score matching, 2,885 patients from each group were included in the analysis. Fracture incidence was compared between groups. Kaplan-Meier curves were used to compare mortality. Cox proportional hazards regression analysis was used to compare the risks of fracture occurrence and mortality between the groups.

Results: The incidence rate (138.6/10,000 vs. 192.4/10,000 person-years), and risk of osteoporotic fractures (hazard ratio HR, 0.77; 95% confidence interval CI, 0.61-0.97; p = 0.024) were lower in the SERM + VitD group than in the SERMs group.
Analysis for specific fractures showed a lower hazard of hip fracture in the SERM + VitD group (HR, 0.25; 95% CI, 0.09-0.71; p = 0.009). No difference was observed between the groups regarding mortality.

Conclusion: The risk of osteoporotic fractures, especially hip fractures, was lower in the SERM + VitD group than in the SERMs group. Therefore, the composite agent of SERMs and vitamin D can be considered as a viable option for postmenopausal women with a relatively low fracture risk.

26 References
  1. Sattui SE, Saag KG (2014) Fracture mortality: associations with epidemiology and osteoporosis treatment. Nat Rev Endocrinol 10:592–602 - DOI - PubMed
  2. Kim KW, Kim OS (2020) Super aging in South Korea unstoppable but mitigatable: a sub-national scale population projection for best policy planning. Spat Demogr 8:155–173. https://doi.org/10.1007/s40980-020-00061-8 - DOI - PubMed - PMC
  3. Riggs BL, Hartmann LC (2003) drug therapy selective estrogen-receptor modulators-mechanisms of action and application to clinical practice. N Engl J Med 348:618–629 - DOI - PubMed
  4. Lee N, Choi YJ, Chung Y-S (2020) The secular trends in the use of medications for osteoporosis in South Korea using Intercontinental Medical Statistics Health Sales Audit 2006–2018. Osteoporos Sarcopenia 6:185–190. https://doi.org/10.1016/j.afos.2020.11.007 - DOI - PubMed - PMC
  5. Ceglia L (2009) Vitamin D and Its role in skeletal muscle. Curr Opin Clin Nutr Metab Care 12:628–633. https://doi.org/10.1097/MCO - DOI - PubMed - PMC
  6. Feng Y, Cheng G, Wang H, Chen B (2017) The associations between serum 25-hydroxyvitamin D level and the risk of total fracture and hip fracture. Osteoporos Int 28:1641–1652. https://doi.org/10.1007/s00198-017-3955-x - DOI - PubMed
  7. Carmel AS, Shieh A, Bang H, Bockman RS (2012) The 25(OH)D level needed to maintain a favorable bisphosphonate response is ≥33 ng/ml. Osteoporos Int 23:2479–2487. https://doi.org/10.1007/s00198-011-1868-7 - DOI - PubMed - PMC
  8. Camacho PM, Petak SM, Binkley N et al (2020) American association of clinical endocrinologists/American college of endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis-2020 update. Endocr Pract 26:1–46 - DOI - PubMed
  9. Yoo JI, Ha YC, Park KS et al (2019) Incidence and mortality of osteoporotic refractures in Korea according to nationwide claims data. Yonsei Med J 60:969–975. https://doi.org/10.3349/ymj.2019.60.10.969
  10. Balasubramanian A, Tosi L, Lane J et al (2014) Declining rates of osteoporosis management following fragility fractures in the U.S., 2000 through 2009. J Bone Joint Surg Am 96:e52
  11. Klotzbuecher CM, Ross PD, Landsman PB et al (2000) Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res 15:721–739. https://doi.org/10.1359/jbmr.2000.15.4.721 - DOI - PubMed
  12. Quan H, Sundararajan V, Halfon P et al (2005) Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care 43:1130–1139 - DOI - PubMed
  13. Barrett-Connor E, Mosca L, Collins P et al (2006) Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women. N Engl J Med 355:125–137 - DOI - PubMed
  14. Ettinger B, Black DM, Mitlak BH et al (1999) Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene results from a 3-year randomized clinical trial. Multiple outcomes of raloxifene evaluation (MORE) investigators. JAMA 282:637–645
  15. Khalid S, Calderon-Larrañaga S, Hawley S et al (2018) Comparative anti-fracture effectiveness of different oral anti-osteoporosis therapies based on “real-world” data: a meta-analysis of propensity-matched cohort findings from the uk clinical practice research database and the catalan sidiap database. Clin Epidemiol 10:1417–1431. https://doi.org/10.2147/CLEP.S164112 - DOI - PubMed - PMC
  16. Bischoff-Ferrari H, Dietrich T, Orav E, Dawson-Hughes B (2004) Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med 116:634–639 - DOI - PubMed
  17. Bischoff-Ferrari HA, Willett WC, Wong JB et al (2005) Fracture prevention with vitamin D supplementation. JAMA 293:2257–2264 - DOI - PubMed
  18. LeBoff MS, Chou SH, Ratliff KA et al (2022) Supplemental vitamin D and incident fractures in midlife and older adults. N Engl J Med 387:299–309. https://doi.org/10.1056/nejmoa2202106 - DOI - PubMed - PMC
  19. Anagnostis P, Bosdou JK, Kenanidis E et al (2020) Vitamin D supplementation and fracture risk: evidence for a U-shaped effect. Maturitas 141:63–70. https://doi.org/10.1016/j.maturitas.2020.06.016 - DOI - PubMed
  20. Park JH, Hong IY, Chung JW, Choi HS (2018) Vitamin D status in South Korean population: seven-year trend from the KNHANES. Medicine (Baltimore) 97:e11032. https://doi.org/10.1097/MD.0000000000011032 - DOI - PubMed
  21. Yoo KO, Kim MJ, Ly SY (2019) Association between vitamin d intake and bone mineral density in Koreans aged ≥ 50 years: analysis of the 2009 Korea National Health and Nutrition Examination Survey using a newly established vitamin D database. Nutr Res Pract 13:115–125. https://doi.org/10.4162/nrp.2019.13.2.115
  22. Gorai I, Hattori S, Tanaka Y, Iwaoki Y (2012) Alfacalcidol-supplemented raloxifene therapy has greater bone-sparing effect than raloxifene-alone therapy in postmenopausal Japanese women with osteoporosis or osteopenia. J Bone Miner Metab 30:349–358 - DOI - PubMed
  23. Liu HJ, Kim SA, Shim DJ et al (2019) Influence of supplementary Vitamin D on bone mineral density when used in combination with selective estrogen receptor modulators. J Menopausal Med 25:94. https://doi.org/10.6118/jmm.19193 - DOI - PubMed - PMC
  24. Zhang Y, Fang F, Tang J et al (2019) Association between vitamin D supplementation and mortality: systematic review and meta-analysis. BMJ 366:l4673 - DOI - PubMed - PMC
  25. Keum N, Lee DH, Greenwood DC et al (2019) Vitamin D supplementation and total cancer incidence and mortality: a meta-analysis of randomized controlled trials. Ann Oncol 30:733–743 - DOI - PubMed - PMC
  26. Neale RE, Baxter C, Romero BD et al (2022) The D-health trial: a randomised controlled trial of the effect of vitamin D on mortality. Lancet Diabetes Endocrinol 10:120–128. https://doi.org/10.1016/S2213-8587(21)00345-4 - DOI - PubMed

76+ Hip fracture studies in VitaminDWiki

This list is automatically updated

Items found: 77
Title Modified
Hip fractures 60% more likely in people who drank a lot of milk - Greger Feb 2024 14 Feb, 2024
Hip fracture risk was reduced by 4 times when Vitamin D was added to SERMS - Jan 2024 25 Jan, 2024
Risk of Hip fracture cut in half if Vitamin D was prescribed - Aug 2023 26 Aug, 2023
Hip fractures are predicted by 10 factors – low Vitamin D is the biggest – Aug 2023 11 Aug, 2023
Hip fractures greatly reduced by sunshine, vitamin D, and vitamin K – meta-analysis Sept 2012 23 Dec, 2022
Hip fractures requiring hospitalization cut in half by Vitamin K1 (100 mcg per day) – Sept 2022 17 Dec, 2022
More hip fractures if low vitamin D (2.1X in case-controlled studies) – meta-analysis May 2022 01 Jun, 2022
Less than 3 percent of hip fracture patients prescribed enough Vitamin D to make a difference (Malta in this case) – July 2021 26 Jul, 2021
Recommends vitamin D after hip fracture ( but not enough and no-bone building co-factors) – May 2021 21 May, 2021
A call to action: Vitamin D for hip fracture (50,000 weekly for 8 weeks, then bi-weekly – Holick July 2020 11 Dec, 2020
Risk factors for death after hip fracture surgery – 7 of the 8 are associated with low vitamin D – Aug 2020 09 Aug, 2020
Guideline following hip fracture – 50000 IU vitamin D daily for 7 days – Jan 2013 07 Jun, 2020
3.5 X higher risk of death 2 years after hip fracture surgery if low vitamin D – Jan 2020 07 Mar, 2020
Hip surgery with multiple doses of 50,000 IU of vitamin D weekly both before and after – RCT 2023 16 Jan, 2020
Hip fractures not prevented by Vitamin D (800 IU daily or large quarterly or annual doses) – meta-analysis – Dec 2019 21 Dec, 2019
Hip fractures reduced 16 to 33 percent by any amount of Vitamin D and Calcium – Oct 2019 05 Nov, 2019
Hip fracture rate increases in winter (subtropical Australia too) – Aug 2019 10 Aug, 2019
Warning - High intake of Vitamin B12 and B6 found to increase risk of hip fracture by 47 percent - 2019 19 May, 2019
Following hip fracture 2,000 IU of vitamin D daily improved quality of life – Feb 2019 23 Mar, 2019
Hip fractures worse if both high PTH and low Vitamin D – Jan 2019 01 Feb, 2019
Hip fracture recovery best with home exercise plus Vitamin D – RCT Dec 2018 12 Dec, 2018
Death of older hip fracture patients at least 1.6X more likely if low vitamin D – May 2018 19 Nov, 2018
After hip surgery Vitamin D levels dropped by 32 percent – Sept 2018 26 Sep, 2018
France wants to reduce hip fractures by drinking 10 glasses of milk daily – April 2018 01 Apr, 2018
Hip fractures rates have been increasing since 2012 – Feb 2018 12 Feb, 2018
Hip fracture 58 percent more likely if low vitamin D – meta-analysis March 2017 20 Dec, 2017
Hip fracture risk reduced 6 percent for each daily dairy serving (more if full-fat dairy) – Oct 2017 28 Oct, 2017
France is planning to reduce hip fractures by dairy vitamin D fortification (plan will not work) – 2017 17 Oct, 2017
Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016 23 Aug, 2017
Most Hip fracture patients had low vitamin D and protein (needed for strong bones) – May 2017 18 May, 2017
1 in 3 died after hip fracture but only 1 in 14 if add Vitamin D and exercise – RCT April 2017 19 Apr, 2017
Vitamin D loading dose after hip fracture surgery was great – RCT Aug 2016 06 Apr, 2017
Following a stroke, a hip fracture is 6X more likely if low vitamin D – July 2001 04 Mar, 2017
Gene makes Hip Fracture 2.5X more likely unless get more vitamin D - Aug 2015 12 Nov, 2016
Partial (proximal) hip fracture strongly associated with low Vitamin D – Aug 2016 08 Nov, 2016
24 years ago hip fractures were reduced 24 percent in a large trial using Vitamin D and Ca – Oct 2016 22 Oct, 2016
Kaiser working to decrease hip and other fractures – Nov 2011 22 Oct, 2016
Hip Fracture 2.5 times more likely if poor Vitamin D Binding Protein gene - Aug 2015 25 Sep, 2016
Hip fracture risk increased 2.5X if problem with Vitamin D Receptor gene (GC) – March 2014 25 Sep, 2016
Hip fracture 50 percent more likely if low in both vitamin D and vitamin K1 – Dec 2015 26 Dec, 2015
Hip fracture 3X more likely if low vitamin D – Dec 2015 26 Dec, 2015
5X fewer hip fractures from Parkinson – Alzheimer – Stroke with enough sun – June 2011 17 Jul, 2015
7 X more likely to get hip fracture if have highest level of vitamin A – Jan 2003 31 May, 2015
Delirium 2.7 X more likely after hip fracture and low vitamin D – May 2015 27 May, 2015
Hip fractures reduced 30 percent with 800 IU of vitamin D – meta-analysis July 2012 16 Mar, 2015
Hip fracture outcome 5X more likely to be poor if low vitamin D – Jan 2015 16 Mar, 2015
Hip fracture rate varies with latitude (and thus vitamin D) in Sweden – Nov 2013 20 Feb, 2015
Hip Fracture – 5X more likely to have bad outcome if have less than 20 ng of vitamin D – Dec 2014 22 Jan, 2015
Hip replacement 2X more likely if hip bone surgery was during winter (low vitamin D) – Dec 2014 05 Dec, 2014
Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013 09 Nov, 2014
Hip fracture – not getting enough vitamin D – 2013 28 May, 2014
Hip fractures reduced 2X to 6X with just 10 minutes of sunlight daily – RCT 2003-2010 04 Dec, 2013
Men with hip fracture were 1.6X more likely to have low vitamin D – Aug 2013 09 Nov, 2013
5X increase in hip fracture rates in 65 years - 1998 27 Aug, 2013
Hip fracture reduced 38 percent with Calcium and just 400 IU of vitamin D – RCT Feb 2013 17 Aug, 2013
20 percent fewer male hip fractures if more Magnesium in the water – July 2013 11 Jul, 2013
Half as many hip fractures if take Calcium, hormones, and a tiny amount of vitamin D – July 2013 26 Jun, 2013
Male Hip fracture 1.65X more likely if low vitamin D – May 2013 01 Jun, 2013
Vitamin D needed to prevent and treat hip fracture, but only 20 percent got any – May 2013 31 May, 2013
Tiger got surgery for hip arthritis – not much sun in the cage – March 2013 23 Mar, 2013
Having less than 25 ng of vitamin D was associated with severe hip fracture – March 2011 30 Jan, 2013
Hip fracture 19 percent less likely with just 4 ng higher level of vitamin D – Dec 2012 20 Dec, 2012
Hip fracture and vitamin D – Health ABC study – May 2012 28 Sep, 2012
Hip surgery followed by 100000 IU then 1000 IU of vitamin D daily – June 2010 31 Aug, 2012
2X to 3X higher hip fracture rate in Asia in past 30 years – Aug 2012 18 Aug, 2012
Cataract surgery resulted in 30 percent fewer hip fractures – July 2012 02 Aug, 2012
Hip fractures in India - editorial with recommendation - Sept 2010 06 Jul, 2012
Women with hip fractures very low on vitamins D3 and K – Mar 2011 06 Jul, 2012
Upper body bones fractured along with hip when extremely low on vitamin D – Sept 2010 24 Jun, 2012
30 percent less chance of dying after hip fracture if take vitamin D and other drugs – 2011 24 Jun, 2012
75 percent of hip fractures associated with vitamin D deficiency - Jan 2011 24 Jun, 2012
Vitamin D 2nd most recommended way to prevent next hip fracture – Nov 2010 23 Jun, 2012
Hip fractures worse if very low on vitamin D – Mar 2011 23 Jun, 2012
Hip fracture patients had only 16 ng of vitamin D – May 2011 23 Jun, 2012
Declining hip fracture rates in the United States – unknown reason – June 2010 23 Jun, 2012
Vitamin K1 reduced hip fracture but Vitamin K2 did not – Aug 2011 23 Jun, 2012
Calcium and vitamin D supplements after hip fracture reduced death rate by 25% – Feb 2011 19 Nov, 2011

VitaminDWiki – Falls and Fractures category

Falls

Fracture


Hip fracture risk was reduced by 4 times when Vitamin D was added to SERMS - Jan 2024        
526 visitors, last modified 25 Jan, 2024,
Printer Friendly Follow this page for updates
Falls and Fractures 254
Page actions
Print
Edit Files 1

Attached files

ID Name Comment Uploaded Size Downloads
20688 Hip D.png admin 22 Jan, 2024 26.98 Kb 98