Polymorphisms in vitamin D receptor and parathyroid hormone genes in the development and progression of obstructive sleep apnea in Asian Indians
Nutrition. Volume 89, September 2021, 111237, https://doi.org/10.1016/j.nut.2021.111237
Surya Prakash Bhatt Ph.D.Randeep Guleria D.M.
Vitamin D (ng) and Apnea index (events/hour) chart from study via Google Images
Vitamin D Receptor is associated in over 40 autoimmune studies
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
Vitamin D Receptor activation can be increased by any of: Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, intense exercise, Ginger, Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators
Items in both categories Vitamin D Receptor and Obese are listed here:
- Obesity is associated with 1 to 5 poor vitamin D genes (childhood obesity in the case) – July 2024
- Obesity decreases BOTH Vitamin D levels and Vitamin D Receptor activation – Oct 2023
- Risk of sleep apnea in obese increases 3.4X with poor vitamin D Receptor – Sept 2021
- Large weight loss 32X more likely to be achieved if weight gain was due to Vitamin D Receptor – Jan 2020
- Obesity 2X higher risk if a poor Vitamin D Receptor (13th study) – Dec 2019
- Obesity 1.5 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2019
- Obesity associated with poor Vitamin D genes (VDR in this study) – Jan 2018
- Skin fold thickness but not BMI associated with poor Vitamin D Receptor in Han Chinese – April 2018
- Resveratrol improves health (Vitamin D receptor, etc.) - many studies
- Obesity might be related to Vitamin D genes – July 2018
- Obesity 1.5 X more likely if poor Vitamin D receptor – Dec 2017
- Obesity in 700 young adults associated with a poor Vitamin D Receptor – Jan 2018
- Obese are 30 percent more likely to have poor Vitamin D Receptor – Aug 2017
- Vitamin D restricted in getting to cells by genes, obesity, etc – Jan 2017
- Vitamin D Receptor and Obesity – many studies
- Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016
- Obesity strongly associated with vitamin D receptor in Saudia Arabia – July 2014
13+ VitaminDWiki pages have SLEEP APNEA in the title
This list is automatically updated
Objectives
Vitamin D plays a role in multiple aspects of human physiology, and vitamin D receptor (VDR) and parathyroid hormone (PTH) genes are associated with obesity. No data are available, to our knowledge, on the possible relationship between obstructive sleep apnea (OSA) and genetic variations of VDR and PTH genes. This study aimed to assess the significance of vitamin D and PTH, as well as VDR, and PTH gene polymorphisms with body composition and biochemical investigations in Asian Indians with and without OSA.
Methods
In this study, 120 obese subjects with OSA, 110 obese subjects without OSA, and 70 nonobese subjects without OSA were recruited. Clinical, body composition, anthropometry, and biochemical investigations, as well as a full overnight polysomnography were measured. Genotyping related to VDR (BsmI, ApaI FokI, and TaqI) and PTH (BstBI and DraII) genes were investigated with a quantitative real-time polymerase chain reaction.
Results
The mean values of the lower serum 25(OH) D (12.9 ± 3.8; P = 0.0001) and higher serum PTH levels (61.9 ± 12.5; P = 0.0001) were observed in obese subjects with OSA. There was an indirect correlation between serum 25(OH) D levels and OSA severity (P < 0.001). VDR (BsmI and FokI) and PTH (BstBI and DraII) genes were significantly associated with OSA (P < 0.05). Analyses of VDR haplotype combination variants (BBFFAATt [odds ratio: 3.45; 95% confidence interval, 0.986–4.567] and BbFFAaTt [odds ratio: 2.86; 95% confidence interval, 1.345–4.981) were more frequent in obese subjects with OSA (P = 0.001). The BBDD and bbDd haplotypes of the PTH gene seems to be a predisposing factor for OSA (P < 0.05).
Conclusions
Lower serum 25(OH) D levels were significantly observed in patients with OSA and correlate with disease severity. Also, VDR and PTH mutations were found to be highly related with OSA in Asian Indians.