Vitamin D supplementation and survival of patients with non-small-cell lung cancer: A randomized, double-blind, placebo-controlled trial.
Clin Cancer Res. 2018 Jul 17. pii: clincanres.0483.2018. doi: 10.1158/1078-0432.CCR-18-0483. [Epub ahead of print]
1200 IU for 8 years
Relapse-Free-Survival for those starting with < 20 ng of vitamin D
years
It is amazing that such a small amount of Vitamin D would help.
Suspect that the Japanese patients were very light-weight
Would need larger doses for standard-weight adults
Larger doses would likely also provide more benefits
Releapse-Free-Survival vs genes (not Vitamin D)
years
- Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017
- Lung cancer and inhaled emulsions (wonder about inhaled Vitamin D) – 2018
- Live longer with lung cancer if have good vitamin D genes (or perhaps lots of vitamin D) – Dec 2017
- Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017
- Lung cancer death reduction: CT scan or Vitamin D – which is 40X less expensive
- Cancer patients 64% less likely to die if have high level of vitamin D – Dec 2011 has the following chart
Vitamin D both prevents and treats many cancers
Cancer category starts with the following
- Cancer
293 items Overview Cancer and vitamin D - Cancer and Vitamin D - many studies
- After Cancer Diagnosis
113 items - Bladder Cancer
28 items - Breast Cancer
259 items Overview Breast Cancer and Vitamin D - Colon Cancer
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19 items - Liver Cancer
17 items - Lung Cancer
55 items Overview Lung cancer and vitamin D - Lymphoma Cancer
26 items - Other Cancer
66 items - Ovarian Cancer
26 items - Pancreatic Cancer
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103 items Overview Prostate Cancer and Vitamin D - Skin Cancer
121 items Overview Suntan, melanoma and vitamin D - Childhood Cancers - Vitamin D can help - many studies
- Easiest way to treat cancer – take Vitamin D – Nov 2022
- 13 Cancers are helped by Vitamin D – Biobank July 2023
- 2X increase of 14 cancers in non-seniors in 20 years (low vitamin D) – Sept 2022
- Vitamin D prevents and treats cancer in many ways – May 2021
- Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
- 8 ways that Cancer might be prevented by Vitamin D - June 2019
- Cancer stem cells and Vitamin D - many studies
- Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
- Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
- Melanoma 25 X more likely if low vitamin D – Feb 2018
- Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018
Cancers get less Vitamin D when there is a poor Vitamin D Receptor- Vitamin D Receptor pages in VitaminDWiki with CANCER in title 86 as of July 2023
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Vitamin D Receptor (Cancers OR Viruses) - many studies
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer (general) and VDR
23 articles - Breast Cancer and VDR
24 articles - Colon Cancer and VDR
13 articles - Prostate Cancer and VDR
7 articles - Skin Cancer and VDR
10 articles - Note some Health problems, such as some Cancers, protect themselves
by actively reducing Receptor activation
PDF is available free at Sci-Hub 10.1158/1078-0432.CCR-18-0483
Akiba T1, Morikawa T2, Odaka M2, Nakada T2, Kamiya N3, Yamashita M2, Yabe M2, Inagaki T2, Asano H2, Mori S2, Tsukamoto Y2, Urashima M4.
1 Thoracic Surgery, Jikei University School of Medicine University Hospital.
2 Thoracic Surgery, Tokyo Jikei University of Medicine.
3 Thoracic Surgery, Kitasato University Kitasato institute hospital.
4 Molecular Epidemiology, Jikei University School of Medicine urashima@jikei.ac.jp.Higher serum 25-hydroxyvitamin D (25(OH)D) levels are reportedly associated with better survival in early-stage non-small-cell lung cancer (NSCLC). Therefore, whether vitamin D supplementation can improve the prognosis of NSCLC patients was examined (UMIN000001869). Experimental
Design: A randomized, double-blind trial comparing vitamin D supplements (1,200 IU/day) with placebo for 1 year after operation was conducted. The primary and secondary outcomes were relapse-free survival (RFS) and overall survival (OS), respectively. Pre-specified subgroup analyses were performed with stratification by stage (early vs. advanced), pathology (adenocarcinoma vs. others), and 25(OH)D levels (<20 ng/ml vs. high, ≥20 ng/ml). Polymorphisms of vitamin D receptor (VDR) and vitamin D binding protein (DBP) and survival were also examined.
Results: NSCLC patients (n=155) were randomly assigned to receive vitamin D (n=77) or placebo (n=78) and followed for a median of 3.3 years. Relapse and death occurred in 40 (28%) and 24 (17%) patients, respectively. In the total study population, no significant difference in either RFS or OS was seen with vitamin D compared to the placebo group.
However, by restricting the analysis to the subgroup with early-stage adenocarcinoma with low 25(OH)D, the vitamin D group showed significantly better- 5-year RFS (86% vs. 58%, P=0.04) and
- OS (92% vs. 56%, P=0.02)
than the placebo group. Among the examined polymorphisms, DBP1 (rs7041) TT and CDX2 (rs11568820) AA/AG genotypes were markers of better prognosis, even with multivariate adjustment.
Conclusions: In NSCLC patients, vitamin D supplementation may improve survival of early-stage lung adenocarcinoma patients with lower 25(OH)D levels.Printer Friendly Follow this page for updates4802 visitors, last modified 04 Sep, 2018, - Breast Cancer and VDR