4X fewer COVID-19 deaths in those having high Omega-3 index – Jan 6, 2021

Blood omega-3 fatty acids and death from COVID-19: A Pilot Study

medRxiv preprint doi: https://doi.org/10.1101/2021.01.06.21249354;


4% death rate if Omega-3 index >5.7
17% death rate if Omega-3 index <5.7
Comments by VitaminDWiki


Optimal levels speculation

  • <10% of the population have an optimal level of Vitamin D or Omega-3 or Magnesium
  • < 2% of the population have optimal levels of all three
  • It appears difficult to have an optimal level in one of the nutrients without having at least an OK level in the other two

Fun Fact - Olympics committee has declared that supplementing with Vitamin D and Omega-3 is useful and is not "doping"

 Download the PDF from VitaminDWiki

Arash Asher, Nathan L. Tintle2,3, Michael Myers4, Laura Lockshon1, Heribert Bacareza5, and William S. Harris,6 wsh@faresinst.com
1Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles, CA.
2Fatty Acid Research Institute, Sioux Falls, SD
3Department of Mathematics and Statistics, Dordt University, Sioux Center, IA
4Los Alamitos Medical Center, Los Alamitos, CA
5Department of Medical Affairs, Cedars-Sinai Medical Center, Los Angeles, CA
6Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD

Very-long chain omega-3 fatty acids (EPA and DHA) have anti-inflammatory properties that may help reduce morbidity and mortality from COVID-19 infection. We conducted a pilot study in 100 patients to test the hypothesis that RBC EPA+DHA levels (the Omega-3 Index, O3I) would be inversely associated with risk for death by analyzing the O3I in banked blood samples drawn at hospital admission. To have adequate power (>80%) in this pilot study, we pre-specified a significance level of 0.10. Fourteen patients died, one of 25 in quartile 4 (Q4) (O3I >5.7%) and 13 of 75 in Q1-3. After adjusting for age and sex, the odds ratio for death in patients with an O3I in Q4 vs Q1-3 was 0.25, p=0.07. Thus, we have suggestive evidence that the risk for death from COVID-19 was lower in those with the highest O3I levels. These preliminary findings need to be confirmed in larger studies.

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