Toggle Health Problems and D

Elderly should not have more than 40 ng of vitamin D (if infrequent dosing or fail to adjust cofactors) Aug 2017

The Biphasic Effect of Vitamin D on the Musculoskeletal and Cardiovascular System.

Int J Endocrinol. 2017;2017:3206240. doi: 10.1155/2017/3206240. Epub 2017 Aug 23.
Zittermann A1.
Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany.

 Download the PDF from VitaminDWiki

This narrative review summarizes beneficial and harmful vitamin D effects on the musculoskeletal and cardiovascular system. Special attention is paid to the dose-response relationship of vitamin D with clinical outcomes. In infants and adults, the risk of musculoskeletal diseases is highest at circulating 25-hydroxyvitamin D (25OHD) concentrations below 25 nmol/L and is low if 40-60 nmol/L are achieved. However, evidence is also accumulating that in elderly people the risk of falls and fractures increases again at circulating 25OHD levels > 100 nmol/L. Cohort studies report a progressive increase in cardiovascular disease (CVD) events at 25OHD levels < 50 nmol/L. Nevertheless, meta-analyses of randomized controlled trials suggest only small beneficial effects of vitamin D supplements on surrogate parameters of CVD risk and no reduction in CVD events. Evidence is accumulating for adverse vitamin D effects on CVD outcomes at 25OHD levels > 100 nmol/L, but the threshold may be influenced by the level of physical activity. In conclusion, dose-response relationships indicate deleterious effects on the musculoskeletal system and probably on the cardiovascular system at circulating 25OHD levels < 40-60 nmol/L and >100 nmol/L. Future studies should focus on populations with 25OHD levels < 40 nmol/L and should avoid vitamin D doses achieving 25OHD levels > 100 nmol/L.

PMID: 28912809 PMCID: PMC5587949 DOI: 10.1155/2017/3206240

Created by admin. Last Modification: Wednesday October 4, 2017 00:39:37 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
8440 More than 40 ng too much for elderly.pdf PDF 2017 admin 16 Sep, 2017 11:40 1.53 Mb 738