Circulating 25-hydroxyvitamin D up to 3 decades prior to diagnosis in relation to overall and organ-specific cancer survival.
Eur J Epidemiol. 2018 Nov;33(11):1087-1099. doi: 10.1007/s10654-018-0428-2.
- Vitamin D and Cancer Mortality – review Jan 2013
- 40 ng Vitamin D perhaps optimal for reduced mortality – Meta-analysis Jan 2012
- Dr. Grant on vitamin D and mortality in VitaminDWiki
- Cancer deaths of senior women 60 percent more likely if low Vitamin D – March 2015
- All items in Mortality and vitamin D
319 items - Mortality category listing has the following chart
click on image for details
The TOP articles in Mortality and Vitamin D are listed here:- More vitamin D means fewer deaths – many studies
- Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
- COVID survival in Europe in 2020 best predicted by population-level Vitamin D (of 13 variables) – July 2022
- 18 million excess global deaths in past 2 years: COVID plus collateral damage - Lancet March 2022
- Pop quiz: What is the percentage decrease in deaths by a Vitamin D increase of 10 nmol
- Those raising Vitamin D above 30 ng were 1.4 X less likely to die of Heart Attack (VA 19 years) – Oct 2021
- COVID-19 mortality extrapolates to zero at 50 ng of vitamin D – 18th Meta-analysis Sept 2021
- Longevity expert (Sinclair) supplements include Vitamin D, Vitamin K, and Resveratrol – Sept 2019
- Which Is Worse - Avoiding Sunlight or Vitamin D Deficiency – April 2019
- Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019
- Low Vitamin D is associated with dying sooner (70 studies) – meta-analysis Jan 2019
- Vitamin D reduces the risk of Breast Cancer, improves treatment, and improves survival
- Telomeres in boys were 2.5% longer if 9 ng higher vitamin D – July 2018
- Vitamin D - at least 4,000 IU to achieve 40-60 ng and reduce risk of early death – Holick June 2018
- Death within 2 years of surviving an ischemic stroke 10X less likely if high vitamin D – July 2017
- Causes of Death - Vitamin D reduces 10 of the top 11 - July 2017
- 2.4 times more likely to die if low Vitamin D (11,000 people for 14 years) – Sept 2016
- Vitamin D extends lifespan about 60 percent (for worms in a lab) – Oct 2016
- Vitamin D and exercise after hip fracture surgery – far fewer deaths – July 2016
- All-cause mortality is related to low Magnesium, rather than low Vitamin D – April 2015
- Chance of dying of various conditions reduced by higher levels of vitamin D – May 2015
- Vitamin D intervention increased by 20 percent the survival of critically ill patients- RCT June 2014
- 1.9 X more likely to die if very low vitamin D – June 2014
- Fewer heart attacks, hip fractures and deaths if more skin cancer – Sept 2013
- 3X more likely to die within 3 months of being in ICU for 2 days if less than 20 ng vitamin D – Sept 2013
- Why do gardeners live longer (vitamin D, etc.)
- Chance of dying increases by 25 percent in seniors if low vitamin D – Meta-analysis July 2013
- More sepsis deaths when active vitamin D (Calcitrol) was low – May 2013
- Vitamin D protects against many types of health problems – review May 2013
- Almost 6X more likely to die after coronary bypass if vitamin D deficient – Dec 2012
The study on this page did not mention Breast Cancer
- Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
The study on this page did not mention Lung Cancer
Note: Vitamin D also reduces the chance of getting cancer
- Chart of Vitamin D levels vs disease - Grassroots Health June 2013 contains the following chart of incidence, not mortality
Items in both categories Cancer and Mortality are listed here:
- Fewer deaths (All-cause, Cardiovascular, Cancer) when Vitamin D levels are above 36 ng – April 2024
- People with Cancer having more than 30 ng of Vitamin D are 40% less likely to die (of any cause) – Nov 2023
- Cancer incidence or mortality not changed by small Vitamin D doses: 2021-2023
- Cancer mortality reduced 40 pcnt by 2000 IU Vitamin D daily if normal weight – Meta-analysis June 2022
- Cancer incidence and death reduced by both Vitamin D and UVB – Grant Oct 2021
- Cancer mortality not reduced by small vitamin D doses - Sept 2021
- Cancer death (non-skin) 2.3 X more likely if low Vitamin D – Aug 2021
- 2,000 IU of Vitamin D daily to German Seniors would save 30,000 lives a year – March 2021
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Cancer is leading cause of death - Vitamin D and Receptor activators help
- Vitamin D Supplements Reduce Cancer Mortality – Greger Sept 2019
- Mortality increased: 4X Cancer, 5X Diabetes if eat a lot of meat protein – March 2014
- People supplemented with Vitamin D had 13 percent fewer Cancer deaths – Meta-analysis of RCT June 2019
- Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
- Cancer with low Vitamin D increases Mortality by 13 percent – meta-analysis Feb 2019
- Cancer incidence not reduced by 1100 IU of vitamin D (proven again) but mortality decreased – June 2014
- Cancer survival 4 percent more likely with just a little more vitamin D (4 ng) - meta-analysis July 2014
- Death of women from cancer 24% less likely if 20 ng more vitamin D – meta-analysis Sept 2013
- Vitamin D protects against many types of health problems – review May 2013
- Vitamin D and Cancer Mortality – review Jan 2013
- More US deaths due to cancer than heart if dark skinned – Sept 2012
- Lack of solar UVB in US is associated with some Cancers - 2006
- Mortality and Cancer varies with latitude in France too – 2010
- Solar radiation, vitamin D and cancer incidence and mortality in Norway
PDF is available free at Sci-Hub 10.1007/s10654-018-0428-2
It is Interesting that this study was funded by the US govt but the publisher charges $39 for the taxpayers to see it
Vitamin D levels were measured ~ a decade before Cancer diagnosis
This chart shows the mortality after Cancer diagnosisWeinstein SJ1, Mondul AM2, Yu K3, Layne TM3, Abnet CC3, Freedman ND3, Stolzenberg-Solomon RZ3, Lim U4, Gail MH3, Albanes D3.
- 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 9609 Medical Center Drive, Bethesda, MD, 20892, USA. weinstes@mail.nih.gov.
- 2 Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
- 3 Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 9609 Medical Center Drive, Bethesda, MD, 20892, USA.
- 4 Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
While vitamin D has been associated with improved overall cancer survival in some investigations, few have prospectively evaluated organ-specific survival. We examined the accepted biomarker of vitamin D status, serum 25-hydroxyvitamin D [25(OH)D], and cancer survival in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study.
Of 4616 cancer cases with measured serum 25(OH)D, 2884 died of their cancer during 28 years of follow-up and 1732 survived or died of other causes.
Proportional hazards regression estimated hazard ratios (HR) and 95% confidence intervals (CI) for the association between pre-diagnostic 25(OH)D and overall and site-specific survival. Serum 25(OH)D was significantly lower among cases who subsequently died from their malignancy compared with those who did not (medians 34.7 vs. 36.5 nmol/L, respectively; p = 0.01). Higher 25(OH)D was associated with lower- overall cancer mortality (HR = 0.76, 95% CI 0.67-0.85 for highest vs. lowest quintile, p-trend < 0.0001).
Higher 25(OH)D was related to lower mortality from the following site-specific malignancies:
- prostate (HR = 0.74, 95% CI 0.55-1.01, p-trend = 0.005),
- kidney (HR = 0.59, 95% CI 0.35-0.98, p-trend = 0.28), and
- melanoma (HR = 0.39, 95% CI 0.20-0.78, p-trend = 0.01),
but increased mortality from lung cancer (HR = 1.28, 95% CI 1.02-1.61, p-trend = 0.19).
Improved survival was also suggested for- head and neck,
- gastric,
- pancreatic, and
- liver cancers,
though not statistically significantly, and case numbers for the latter two organ sites were small.
Higher 25(OH)D status years prior to diagnosis was related to improved survival for overall and some site-specific cancers, associations that should be examined in other prospective populations that include women and other racial-ethnic groups.
4743 visitors, last modified 20 Nov, 2018,