1.7 X less risk of Heart Failure death if previously had taken any amount of vitamin D - Jan 2022

Association between Vitamin D and Heart Failure Mortality in 10,974 Hospitalized Individuals

Nutrients 2021, 13(2), 335; https://doi.org/10.3390/nu13020335
by Kenya Kusunose 1,*ORCID,Yuichiro Okushi 1,Yoshihiro Okayama 2,Robert Zheng 1,Miho Abe 1,Michikazu Nakai 3,Yoko Sumita 3,Takayuki Ise 1,Takeshi Tobiume 1,Koji Yamaguchi 1,Shusuke Yagi 1,Daiju Fukuda 1,Hirotsugu Yamada 4,Takeshi Soeki 1,Tetsuzo Wakatsuki 1 andMasataka Sata 1

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A broad range of chronic conditions, including heart failure (HF), have been associated with vitamin D deficiency. Existing clinical trials involving vitamin D supplementation in chronic HF patients have been inconclusive. We sought to evaluate the outcomes of patients with vitamin D supplementation, compared with a matched cohort using real-world big data of HF hospitalization. This study was based on the Diagnosis Procedure Combination database in the Japanese Registry of All Cardiac and Vascular Datasets (JROAD-DPC). After exclusion criteria, we identified 93,692 patients who were first hospitalized with HF between April 2012 and March 2017 (mean age was 79 ± 12 years, and 52.2% were male). Propensity score (PS) was estimated with logistic regression model, with vitamin D supplementation as the dependent variable and clinically relevant covariates.
On PS-matched analysis with 10,974 patients, patients with vitamin D supplementation had

  • lower total in-hospital mortality (6.5 vs. 9.4%, odds ratio: 0.67, p < 0.001) and
  • in-hospital mortality within 7 days (0.9 vs. 2.5%, OR, 0.34, and
  • in-hospital mortality within 30 days 3.8 vs. 6.5%, OR: 0.56, both p < 0.001)

In the sub-group analysis mortalities in patients with age < 75, diabetes, dyslipidemia, atrial arrhythmia, cancer, renin-angiotensin system blocker, and ß-blocker were not affected by vitamin D supplementation. Patients with vitamin D supplementation had a lower in-hospital mortality for HF than patients without vitamin D supplementation in the propensity matched cohort. The identification of specific clinical characteristics in patients benefitting from vitamin D may be useful for determining targets of future randomized control trials.

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Pages with HEART FAILURE in title (43 as of April 2022)

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Items found: 47
Title Modified
Heart Failure and Vitamin D - many studies 10 Aug, 2024
Heart Failure and Vitamin D meta-analyses - many studies 10 Aug, 2024
Chronic Heart Failure helped by Vitamin D – meta-analysis Aug 2024 10 Aug, 2024
Risk of heart failure increased 1.4X if low vitamin D – meta-analysis Dec 2022 28 Dec, 2022
1.7 X less risk of Heart Failure death if previously had taken any amount of vitamin D - Jan 2022 14 Apr, 2022
Chronic Heart Failure reduced by 4,000 IU daily for a year – RCT April 2016 07 Oct, 2021
COVID-19 hospitalizations: 63% associated with diabetes, obesity, hypertension or heart failure – Feb 2021 15 Apr, 2021
Patients on Hemodialysis 3X more likely if die of heart failure if low Magnesium – meta-analysis Jan 2021 26 Mar, 2021
After Heart Failure Blacks are 45 percent more likely to re-enter the hospital in a month – Oct 2020 10 Oct, 2020
Heart Failure may be associated with low Zinc (drugs and gut restrict Zinc) - Jan 2020 15 Jan, 2020
Senior veterans with Heart Failure were 1.8X more likely to be hospitalized if low vitamin D – Feb 2020 31 Dec, 2019
Few people have enough EPA (an Omega-3) to reduce heart failures – July 2019 16 Jul, 2019
Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019 23 Mar, 2019
Small or infrequent doses of vitamin D do not reduce heart failure much – meta-analysis Jan 2018 24 Nov, 2018
Heart Failure is predicted by PTH (but vitamin D both prevents and treats HF) – Jan 2018 31 Mar, 2018
Heart Failure Quality of Life greatly improved by 10,000 IU of vitamin D – RCT Oct 2017 01 Nov, 2017
Heart Failure patients 4 X less likely to benefit from pacemaker (CRT) if low vitamin D – Oct 2017 11 Oct, 2017
Anemia (in heart failure) not treated by Vitamin D (they should have added Iron) – RCT Aug 2017 25 Aug, 2017
Heart Failure with depression increases risk of death by 9.5 X if low vitamin D – Aug 2017 23 Aug, 2017
Acute Heart Failure length of stay and readmission rates cut in half if high vitamin D – Aug 2017 20 Aug, 2017
Heart failure among 137 seniors 12X more likely if low vitamin D – Aug 2017 17 Aug, 2017
Chronic Heart Failure – not enough evidence that Vitamin D helps (but lots of evidence for other cardiovascular problems) – Aug 2017 14 Aug, 2017
Heart Failure not helped by Vitamin D (several strange things about the trial) – RCT May 2017 24 May, 2017
Congestive Heart Failure patients helped with Vitamin D intervention – May 2013 07 Apr, 2017
Vitamin D augmented conventional Congestive Heart Failure treatment in perhaps 10 ways – case reports April 2017 07 Apr, 2017
Chance of death after heart failure reduced by 1000 IU of vitamin D – Feb 2012 04 Jan, 2017
Chronic Heart Failure not treated by Vitamin D, if dose size is ignored – meta-analysis Oct 2015 20 Oct, 2015
Congestive heart failure in infants virtually cured by 1000 IU of vitamin D – RCT Feb 2012 20 Oct, 2015
Heart failure markers reduced by 400 IU of vitamin D and Calcium (surprise) – RCT Jan 2015 18 Mar, 2015
More blood was pumped by those getting 800,000 IU of vitamin D after heart failure – RCT Oct 2013 16 Mar, 2015
Heart Failure early death 2X more likely if less than 20 nanograms of vitamin D – June 2012 11 Feb, 2015
Seniors with Heart Failure helped by daily 4,000 IU of vitamin D (increase 16 ng) – RCT Aug 2014 25 Jul, 2014
Heart pumped more blood after heart failure if more vitamin D – Nov 2010 27 Oct, 2013
Chronic Heart Failure helped with 2,000 IU of vitamin D (PRA reduced) – RCT June 2013 30 Jun, 2013
Heart failure 2X more likely if less than 20 ng of vitamin D – Sept 2012 13 Apr, 2013
Death in less than 2 years of Heart Failure associated with low vitamin D - April 2012 08 Aug, 2012
96 percent of heart failure patients had less than 30 ng of vitamin D – March 2011 28 Apr, 2012
Patent for patients of Chronic Heart Failure includes vitamin D – June 2011 16 Jun, 2011
Heart Failure associated with vitamin D deficiency – Feb 2011 01 Apr, 2011
Review is unsure if supplementing vitamin D will decrease heart failure – Feb 2011 13 Feb, 2011
Calcium with Vitamin D2 then D3 helps A-A after heart failure – Jan 2011 18 Jan, 2011
Review of heart failure and vitamin D mechanisms – Jan 2011 13 Dec, 2010
Heart Failure 3X more likely if less than 30 ng of vitamin D – Sept 2010 16 Sep, 2010
Review of vitamin D and heart failure – Aug 2010 02 Sep, 2010
Lack of vitamin D is a predictor of heart failure – Sept 2010 02 Sep, 2010
The prognostic value of vitamin D in heart failure – July 2010 28 Jul, 2010
Can vitamin D improve quality of life for seniors with heart failure -2010 02 Jun, 2010

VitaminDWiki Meta-anlysis pages with HEART FAILURE in title

This list is automatically updated

Items found: 4

VitaminDWiki - Cardiovascular category

528 items In Cardiovascular category

Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022

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