Vitamin D associated with Parkinson’s Disease in 55 studies, more studies needed- March 2022

Vitamin D and Parkinson's Disease - March 2022

Nutrients. 2022 Mar 14;14(6):1220. doi: 10.3390/nu14061220.
Antonia Pignolo 1, Sergio Mastrilli 1, Chiara Davì 1, Valentina Arnao 2, Paolo Aridon 1, Felipe Augusto Dos Santos Mendes 3, Cesare Gagliardo 1, Marco D'Amelio 1


Vitamin D is a fat-soluble secosteroid, traditionally considered a key regulator of bone metabolism, calcium and phosphorous homeostasis. Its action is made possible through the binding to the vitamin D receptor (VDR), after which it directly and indirectly modulates the expression of thousands of genes. Vitamin D is important for brain development, mature brain activity and associated with many neurological diseases, including Parkinson's disease (PD). High frequency of vitamin D deficiency in patients with Parkinson's disease compared to control population was noted nearly twenty years ago. This finding is of interest given vitamin D's neuroprotective effect, exerted by the action of neurotrophic factors, regulation of nerve growth or through protection against cytotoxicity. Vitamin D deficiency seems to be related to disease severity and disease progression, evaluated by Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn and Yahr (H&Y) scale, but not with age of PD onset and duration of disease. Additionally, fall risk has been associated with lower vitamin D levels in PD. However, while the association between vitamin D and motor-symptoms seems to be possible, results of studies investigating the association with non-motor symptoms are conflicting. In addition, very little evidence exists regarding the possibility to use vitamin D supplementation to reduce clinical manifestations and disability in patients with PD. However, considering the positive balance between potential benefits against its limited risks, vitamin D supplementation for PD patients will probably be considered in the near future, if further confirmed in clinical studies
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Still unsure about vitamin D dose and VDR to fight Parkinson's Disease - June 2022

Vitamin D Status and Parkinson’s Disease
Brain Sciences Volume 12 Issue 6 10.3390/brainsci12060790
by Michela Barichella 1,2,†,Federica Garrì 2,*,†,Serena Caronni 2,Carlotta Bolliri 2,Luciano Zocchi 3,Maria Carmela Macchione 2,Valentina Ferri 2,Daniela Calandrella 2 andGianni Pezzoli 2
1 Parkinson Institute, ASST Gaetano Pini-CTO, 20126 Milan, Italy
2 Fondazione Grigioni per il Morbo di Parkinson, 20126 Milan, Italy
3 Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Sezione di Fisiologia, 20133 Milan, Italy

Parkinson’s disease (PD) is a complex and progressive neurodegenerative disease, characterized by resting tremor, rigidity, slowness of movement, and postural instability. Furthermore, PD is associated with a wide spectrum of non-motor symptoms that add to overall disability. In recent years, some investigations, from basic science to clinical applications, have focused on the role of vitamin D in PD, often with controversial findings. Vitamin D has widespread effects on several biological processes in the central nervous system, including neurotransmission in dopaminergic neural circuits. Various studies have recorded lower levels of vitamin D in PD patients than in healthy controls. Low vitamin D status has also been correlated with the risk for PD and motor severity, whereas less is known about the effects vitamin D has on cognitive function and other non-motor symptoms. This review aims to better characterize the correlation between vitamin D and PD, clarify the role of vitamin D in PD prevention and treatment, and discuss avenues for future research in this field.
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Dr. Coimbra treating autoimmune diseases with high-dose vitamin D

Dr. Coimbra 15 years ago has used high-dose vitamin D to successfully treat Parkinson Disease
He went on to treating many auto-immune diseases with high-dose vitamin D
He has focused on high-dose vitamin D for Multiple Sclerosis, another auto-immune disease

VitaminDWiki pages with COIMBRA in title (36 as of Dec 2022)

This list is automatically updated

Items found: 38
Title Modified
Risk of Autoimmune Uveitis (an outer eye inflammation) decreases 6% for each 1 ng higher level of vitamin D – Coimbra July 2024 02 Jul, 2024
Coimbra high-dose vitamin D protocol - many studies 10 Nov, 2023
Interview and transcript: Vitamin D protocol for Autoimmune diseases – Dr. Coimbra 2016 24 Sep, 2023
Some pathogens and health problems restrict Vitamin D from being used – Coimbra high-dose protocol – April 2021 18 Jan, 2023
Coimbra protocol using high-dose Vitamin D is safe – April 2022 22 Dec, 2022
Beyond the Coimbra Protocol - 2020 22 Mar, 2022
Beyond vitamin D - book of testimonials on high-dose Coimbra Protocol - Aug, 2021 16 Feb, 2022
Multiple Sclerosis treated by Vitamin D, recommends investigating high dose Coimbra - Oct 2021 07 Oct, 2021
Autoimmune and high-dose vitamin D (Dr. Coimbra) - Dr. Mahtani video and transcript - Nov 2020 11 Apr, 2021
Vitamin D Resistance hypothesis confirmed by Coimbra high-dose vitamin D protocol – April 2021 11 Apr, 2021
COVID-19 and high-dose Vitamin D - Video interview of Dr. Coimbra - May 2020 09 Aug, 2020
Dr. Coimbra on Coronavirus and Vitamin D (English transcript) - Jan 2020 31 Jan, 2020
The use of high dose Vitamin D (Coimbra Protocol) for multiple sclerosis in Germany – 2019 26 Nov, 2019
Multiple Sclerosis and Vitamin D chapter (Coimbra and Brazil not mentioned) – Oct 2019 30 Oct, 2019
Ex Coimbra Protocol Clinician Warns Vitamin D3 Can Sometimes Make Multiple Sclerosis Worse. - July 2019 06 Aug, 2019
Most of Coimbra Protocol supplements in a capsule taken 4 times a day – June 2019 16 Jun, 2019
Successful high dose vitamin D (Coimbra Protocol) should be evaluated – June 2019 09 Jun, 2019
Multiple sclerosis - Dr. Coimbra Video in Portuguese concerning big pharma - May 2019 10 May, 2019
Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016 19 Jan, 2019
Multiple Sclerosis - Coimbra Protocol (high-dose Vitamin D) - by one of the 120 doctors of 20,000 patients - Dec 2018 08 Dec, 2018
Interview of Dr. Coimbra: MS, Autoimmune, Vitamin D, B2, Ca, Mg, PTH etc. – perhaps 2018 02 Dec, 2018
Dr. Coimbra discusses Vitamin D, Magnesium, Folic Acid, B12, Autism, Depression, etc – Sept 2018 24 Nov, 2018
Dr. Coimbra interview covering Vitamin D, Magnesium, Folate, Vaccines - Oct 2018 24 Nov, 2018
Multiple Sclerosis Coimbra Protocol stories on Facebook 03 Nov, 2018
Vitamin D is the real Multiple Sclerosis Therapy, not an alternative therapy – Coimbra July 2018 17 Aug, 2018
Guide for patients on high doses of Vitamin D – Coimbra 2017 21 Jun, 2018
How to get lots of Magnesium – especially needed for Coimbra MS and Autoimmune Protocol 30 May, 2018
Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018 27 May, 2018
Multiple Sclerosis Coimbra Protocol with Vitamin D - increased walking - May 2018 12 May, 2018
10,000 IU of vitamin D during pregnancy resulted in spectacular infant development – Coimbra April 2018 17 Apr, 2018
Multiple Sclerosis is reduced by Vitamin D supplementation (even without Coimbra) – review Dec 2017 19 Dec, 2017
Doctor got multiple sclerosis, rejected then embraced Coimbra protocol for herself and patients – Jan 2017 01 Feb, 2017
Video by Dr. Coimbra – 95 percent of auto-immune cured with vitamin D in high doses - April 2014 15 Jan, 2017
Multiple Sclerosis – one person’s benefit of Vitamin D protocol by Dr. Coimbra 22 Jun, 2016
Dr. Coimbra explains his treatment with high dose vitamin D for multiple sclerosis – Feb 2015 27 Apr, 2016
1000 IU per kg Vitamin D for autoimmune diseases – Coimbra Feb 2015 12 Feb, 2015
1000 IU per kg Vitamin D for autoimmune diseases – Coimbra Aug 2013 11 Feb, 2015
Video by Dr. Coimbra – auto-immune cures with high-dose vitamin D in Brazil - April 2014 19 Apr, 2014

VitaminDWiki - Overview Parkinson's and Vitamin D contains

Testimonials of Parkinson's Disease treated by Coimbra Protocol - 2018

URL with before/after video

As with many other health problems, more than Vitamin D will likely be needed

Additional items needed can predicted by looking at succesful high-dose studes
Vitamin K
B vitamins - example: Vitamin B12 and Parkinson’s Disease
As well as activators of the Vitamin D Receptor, such as
infrequent high-doses

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