Periodontitis problems often 3X more likely if poor Vitamin D receptor – May 2022

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Profile of vitamin D receptor gene polymorphism TaqI in patients with periodontitis

Biomed Rep. 2022 May;16(5):35. doi: 10.3892/br.2022.1518
Nurlindah Hamrun 1, Muhammad Ruslin 2, Erni Marlina 3, Sri Oktawati 4, Takashi Saito 5, Andi Sitti Hajrah Yusuf 2, Keng-Liang Ou 6 7

The present study aimed to assess the incidence of the vitamin D receptor (VDR) gene polymorphism TaqI in patients with periodontitis, and the potential association of this polymorphism with the severity of the disease. This was a case-controlled study, which included 162 adults divided into two groups as follows: Case group (81 patients diagnosed with periodontitis) and control group (81 patients without periodontitis). Venous blood was obtained from each sample from which DNA was extracted. The gene polymorphism was determined using restricted fragment length polymorphism-PCR and DNA sequencing to identify endonuclease restrictions in exon 9 (TaqI). The data were analyzed using an independent samples t-test. VDR gene polymorphisms were detected in periodontitis cases with TT (86.4%), Tt (12.4%) and tt (1.2%) genotypes. DNA sequencing confirmed a change in the sequence of the VDR gene nucleotides in patients with periodontitis. The data indicated that the severity of periodontal tissue damage may be influenced by changes in the nucleotide sequence.
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VitaminDWiki - BOTH Dental and Vitamin D Receptor

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VitaminDWiki pages containing PERIODONTITIS in title (18 as of April 2022)

VitaminDWiki pages containing PERIODONTITIS in title

• Severe periodontitis is half as likely at 60 ng of vitamin D – Sept 2021

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VitaminDWiki - Dental category starts

114 Dental items

Some Dental studies

• Vitamin D cut dental caries in half 80 years ago – meta-analysis 2013 80 years ago
• Caries (tooth decay) and Vitamin D - 23+ studies
• Periodontitis reduced by Vitamin D - many studies
  • Periodontal Disease and Vitamin D - interview and transcript - GRH, Grant July 2023
  • Severe periodontitis is half as likely at 60 ng of vitamin D – Sept 2021
  • Vitamin D may provide the most peridontal benefits of all nutraceuticals – May 2018
• Risk of Oral Surgery reduced by Vitamin D – scoping review Nov 2021
• Some Dental Malocclusions 5X more likely if low vitamin D – June 2021
• Grinding teeth while sleeping (sleep bruxism) 6 X more likely if low vitamin D – Jan 2021
• Early tooth decay 1.9 X more likely if a poor Vitamin D receptor – July 2017
• 7 Intervention AND Dental studies
• 18 items listed in BOTH Dental and Infant or Child
• 7 listed in BOTH Dental and Vitamin D Receptor

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VitaminDWiki - The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (22 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (21 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (16 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer and Diabetes, protect themselves by reducing VDR activation
Suspect that SAR-COV-2 also protects itself from Vitamin D

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VitaminDWiki - Ways to increase VDR activation

Resveratrol,  Omega-3,  Magnesium,  Zinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc Note: The founder of VitaminDWiki uses 10 of the 13 known VDR activators