Ovarian Cancer 5.8 X more likely if both low vitamin D and Fok1 gene change – May 2013

Vitamin D and VDR gene polymorphism (FokI) in epithelial ovarian cancer in Indian population.

J Ovarian Res. 2013 May 26;6(1):37.
Mohapatra S, Saxena A, Gandhi G, Koner BC, Ray PC.

INTRODUCTION: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphism, FokI, is reported to increase the risk of many cancers. Role of vitamin D and its receptor polymorphisms in ovarian cancer has not been clearly defined.

OBJECTIVE: To study the levels of serum vitamin D and occurrence of vitamin D receptor gene polymorphism (FokI) in cases of ovarian cancer.

MATERIAL AND METHODS: FokI genotyping was done by PCR-RFLP technique and vitamin D levels were estimated by chemiluminescence immunoassay.

RESULTS: Serum vitamin D levels were significantly (p < 0.03) lower in ovarian cancer cases as compared to controls. The homozygous (TT) and heterozygous (CT) genotype predispose to the development of ovarian cancer in Indian population (OR: 2.37, 95% CI: 1.04-5.44) as compared to the homozygous (CC) genotype.
Vitamin D deficiency and VDR gene polymorphism (FokI) act non-synergistically (p value < 0.4).

CONCLUSION: Low blood levels of vitamin D and VDR receptor polymorphism (FokI) might be a risk factor for the development of ovarian cancer. Other novel ligands of vitamin D receptor might be responsible for the non-synergistic effect.

PMID: 23705897

PDF is attached at the bottom of this page

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Second study one month later (June 2013) is also attached at the bottom of this page

Polymorphisms in the Vitamin D Receptor (VDR) and the Risk of Ovarian Cancer: A Meta-Analysis PLOS ONE

16% increase

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See also VitaminDWiki

• Ovarian Cancer: Interplay of Vitamin D Signaling and miRNA Action. – 2014
• Ovarian cancer: more likely to survive if more vitamin D – Aug 2012
• Calcium and vitamin D appear to be among the few ways to prevent ovarian cancer – 2010
• Ovarian Cancer is somewhat associated with a reduction in 20 ng of vitamin D – Feb 2011
• Difference in Fok gene reduced response to vitamin D by 35 percent – Nov 2012
• All items in category Genetics and Vitamin D 343 items
• Search VitaminDWiki for Fok1 91 items as of Feb 2017
• Ovarian Cancer in Asia is 1.5 X more likely if poor Vitamin D receptor – meta-analysis Dec 2017

Vitamin D Receptor category has the following

530 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 48 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (24 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (14 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (37 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

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55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

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How to increase VDR activation

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement  Sun Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D Receptor
13) Sulfroaphane and perhaps sulfur	Vitamin D Receptor
14) Butyrate especially gut	Vitamin D Receptor
15) Berberine	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR