Magnesium Pidolate may be a good form to reduce headaches – Aug 2020

Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate
VitaminDWiki - 11 studies in both categories Magnesium and Headache
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VitaminDWiki – Headache has the following on metals and migraines
Asked Perplexity AI to Compare Magnesium Pidolate with other forms for reducing headaches

Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate

by Jeanette A. Maier 1,*,Gisele Pickering 2,Elena Giacomoni 3,Alessandra Cazzaniga 1ORCID andPaolo Pellegrino 3
Nutrients 2020, 12(9), 2660; https://doi.org/10.3390/nu12092660

Magnesium deficiency may occur for several reasons, such as inadequate intake or increased gastrointestinal or renal loss. A large body of literature suggests a relationship between magnesium deficiency and mild and moderate tension-type headaches and migraines. A number of double-blind randomized placebo-controlled trials have shown that magnesium is efficacious in relieving headaches and have led to the recommendation of oral magnesium for headache relief in several national and international guidelines. Among several magnesium salts available to treat magnesium deficiency, magnesium pidolate may have high bioavailability and good penetration at the intracellular level. Here, we discuss the cellular and molecular effects of magnesium deficiency in the brain and the clinical evidence supporting the use of magnesium for the treatment of headaches and migraines.
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“A recent observation by Assarzadegan and colleagues [9] indicated that a decrease in magnesium levels in serum increased the odds of acute migraine headaches by a factor of 35 in 40 patients with migraine versus 40 healthy controls, and that magnesium deficiency is an independent risk factor in the incidence of migraines. “
The duration of 1500 mg daily oral magnesium pidolate treatment needed to normalize serum magnesium levels was investigated by Aloisi and colleagues in a study on 40 children designed to evaluate the correlation between magnesium deficiency and the effect on visual evoked potentials. The analysis showed that a treatment lasting 20 days was sufficient to normalize serum magnesium levels in 90% of treated patients.[68]
Magnesium pidolate may have high bioavailability [35,36] and good penetration at the intracellular level [37]. Furthermore, magnesium pidolate is able to reverse magnesium deficiency responsible for headaches, even after a short administration period [31], and to prevent pediatric tension-type headaches [38].
“The Italian Headache Society (SISC) guideline mentions magnesium pidolate supplementation for menstrual migraine and pre-menstrual syndrome patients, but a precise administration schedule has not been established [74]. “
Magnesium pidolate has high bioavailability and good intracellular penetration [82] and it may reverse the magnesium deficiency responsible for headaches, even after a short administration period. Tissue culture and animal model studies indicate that magnesium pidolate may be slightly more effective than other magnesium salts in crossing the BBB [95], and magnesium in general is believed to exert neuroprotective functions. Further studies on the tissue distribution of magnesium pidolate may help to better understand its specific properties.

VitaminDWiki - 11 studies in both categories Magnesium and Headache

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VitaminDWiki – Headache contains

48 Headache pages

Cluster Headache, etc.

21+ VitaminDWiki pages have MIGRAINE in the title
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Items found: 22

Title		Modified
Migraine Headache duration and intensity reduced by 50,000 IU vitamin D every two week plus probiotics – RCT Oct 2024		14 Oct, 2024
Cluster and Migraine headache treatment protocol - Sept 2023		29 Sep, 2023
Migraine and Vitamin D		16 Jul, 2023
Migraine risk reduced 30% if have lots of Zinc - Jan 2023		18 Jan, 2023
Migraines have low vitamin D, Migraines plus Restless Leg have far lower vitamin D (no surprise) – Dec 2021		07 Dec, 2021
Migraine Headache association with poor gut – Feb 2020		25 Feb, 2021
Migraine headaches treated by Vitamin D – meta-analysis Jan 2021		16 Jan, 2021
Migraine headaches reduced with 50,000 IU vitamin D weekly – RCT July 2015		14 Jan, 2021
Why Do Multiple Sclerosis and Migraine Coexist – Jan 2020		28 Jan, 2020
Migraines in youths with low Vitamin D wonderfully treated by Vitamin D – June 2019		12 Jul, 2019
Migraines may be due to lack of lack of Magnesium in half of sufferers – May 2012		25 Oct, 2018
Migraine headache 5X less likely if optimal level of vitamin D – Oct 2018		21 Oct, 2018
Migraine headaches cut in half by 4,000 IU of vitamin D – RCT Sept 2018		06 Sep, 2018
Chronic migraine headaches 1.4 X more likely with low vitamin D – July 2018		05 Jul, 2018
Migraines double the risk of strokes (both are associated with low vitamin D) – Jan 2018		01 Feb, 2018
Vitamin D and Migraine – Nov 2010		06 Sep, 2016
Acute Migraine 35 times more likely if low Magnesium levels – May 2016		12 Jun, 2016
Migraine headaches quickly reduced with Magnesium – Meta-analysis Jan 2016		02 Jun, 2016
Childhood migraine in Vitamin D deficient children reduced 6X by addition of daily 5,000 IU and amitriptyline – April 2014		03 Mar, 2015
Migraine in children reduced with vitamin D supplementation – April 2014		10 Apr, 2014
Migraine more common with high vitamin D, perhaps because of low Magnesium – March 2013		04 Aug, 2013
Migraine headaches associated with low vitamin D, 4,000 IU often helps – review Aug 2019		No value for 'modification_date_major'

VitaminDWiki – Headache has the following on metals and migraines

Compared blood levels of 25 people with migraines to 25 people without GreenMedInfo

Metal	Migraine	No Migraine	Migraine Ratio
Cadmium	0.36 ug	0.09 ug	4X MORE if increase
Iron	0.97 ug	0.48 ug	2X MORE if increase
Lead	1.48 ug	0.78 ug	2X MORE if increase
Magnesium*	10.6 ug	34.5 ug	3.5X LESS if increase
Zinc*	0.24 ug	5.77 ug	24X LESS if increase

Note: Both Zinc and Magnesium increase the activation of the Vitamin D Receptor, which allows more vitamin D into cells

Also

Cluster Headaches treated by high-dose Vitamin D, etc. (interview and transcript) - Feb 2022 Zinc is mentioned
Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial - Sept 2020 No such attachment on this page

Zinc somewhat reduced Migraine in RCT - Sept 2020

Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial https://doi.org/10.1186/s12937-020-00618-9 FREE PDF

Asked Perplexity AI to Compare Magnesium Pidolate with other forms for reducing headaches

Clipped from Feb 2024 answer

Bioavailability and Absorption: The absorption of magnesium from supplements can vary widely, influenced by the specific magnesium salt (e.g., oxide, citrate, pidolate) and the presence of other dietary factors. While magnesium pidolate is suggested to have high bioavailability, other forms like magnesium citrate are also well-absorbed
Conclusion Magnesium pidolate may offer advantages in terms of bioavailability and intracellular penetration, which could theoretically make it more effective for reducing headaches compared to forms with lower bioavailability.

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