Effects of probiotic and vitamin D co-supplementation on clinical symptoms, mental health, and inflammation in adult patients with migraine headache: a randomized, triple-blinded, placebo-controlled trial
BMC Medicine volume 22, Article number: 457 (2024) https://doi.org/10.1186/s12916-024-03684-6
Shahnaz Amani Tirani, Fariborz Khorvash, Parvane Saneei, Zahra Moradmand & Gholamreza Askari
Background
Migraine headache is a major public health problem. Routine medications for migraine treatment are not useful in treating all patients and may have some side effects. The present study aimed to investigate the effect of vitamin D and probiotic co-supplementation on clinical characteristics of migraine, daily functioning, mental health outcomes, and serum levels of high-sensitivity C-reactive protein (hs-CRP).
Methods
In this randomized, triple-blinded, placebo-controlled trial, patients aged 18 to 55 years diagnosed with migraine based on the International Classification of Headache Disorders-3 (ICHD-3) were randomized to either vitamin D (50,000 IU every 2 weeks) plus probiotic (4.5 × 1011 CFU per day) or placebo for 12 weeks. The Headache Impact Test (HIT-6) and Depression, Anxiety, and Stress Scale (DASS) questionnaires were administered to patients at baseline and after 12 weeks. In addition, the frequency, duration, and severity of migraine headaches per month were assessed using a self-administered 30-day headache diary at baseline and the end of the intervention. Anthropometric indices, blood pressure, and serum levels of 25-hydroxy vitamin D and hs-CRP were also examined at first and the end of the study.
Results
Seventy-two migraine patients with a mean age of 37.46 ± 8.32 years were included in this trial. Probiotic and vitamin D co-supplementation compared to placebo resulted in a significant increase in serum levels of vitamin D (+ 12.86 ± 1.64 vs. + 1.12 ± 0.80 ng/mL, P < 0.001). The between-group analysis in the adjusted model showed a significantly greater reduction in migraine headache frequency (− 3.17 ± 0.84 vs. − 1.25
0.34; P = 0.031) and severity (− 1.55 ± 0.35 vs. + 0.67 ± 0.29; P = 0.017) in the probiotic and vitamin D group than the placebo group. No significant difference was found between the two arms of the intervention regarding the change in headache duration, hs-CRP, scores of DASS, and HIT-6 questionnaires (P > 0.05).
Conclusions
This trial showed that probiotic and vitamin D co-supplementation for 12 weeks has beneficial effects on migraine headache characteristics. Further research is needed to confirm this finding.
No such attachment on this page
Data shows that doing something (placebo) that might help helped almost as much
VitaminDWiki – Headache contains
Cluster Headache, etc.
- Cluster and Migraine headache treatment protocol - Sept 2023
- Cluster Headaches treated by high-dose Vitamin D, etc. (interview and transcript) - Feb 2022
- Cluster headaches virtually eliminated in 7,000 people with high-dose vitamin D and cofactors - Feb 2022
- Comparing High-dose vitamin D therapies
- Headaches helped by Vitamin D in 7 studies – Jan 2020
24+ VitaminDWiki pages have MIGRAINE in the title
This list is automatically updated
VitaminDWiki – Headache has the following on metals and migraines
Compared blood levels of 25 people with migraines to 25 people without GreenMedInfo
| Metal | Migraine | No Migraine | Migraine Ratio |
| Cadmium | 0.36 ug | 0.09 ug | 4X MORE if increase |
| Iron | 0.97 ug | 0.48 ug | 2X MORE if increase |
| Lead | 1.48 ug | 0.78 ug | 2X MORE if increase |
| Magnesium* | 10.6 ug | 34.5 ug | 3.5X LESS if increase |
| Zinc* | 0.24 ug | 5.77 ug | 24X LESS if increase |
- Note: Both Zinc and Magnesium increase the activation of the Vitamin D Receptor, which allows more vitamin D into cells
Also
- Cluster Headaches treated by high-dose Vitamin D, etc. (interview and transcript) - Feb 2022 Zinc is mentioned
- Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial - Sept 2020 No such attachment on this page
- Zinc somewhat reduced Migraine in RCT - Sept 2020
Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial https://doi.org/10.1186/s12937-020-00618-9 FREE PDF
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