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Migraine headaches associated with low vitamin D, 4,000 IU often helps – review Aug 2019

Vitamin D in migraine headache: a comprehensive review on literature

Neurological Sciences, pp 1–19
Zeinab Ghorbani Mansoureh Togha Pegah Rafiee Zeynab Sadat Ahmadi Reyhaneh Rasekh Magham Samane Haghighi Soodeh Razeghi Jahromi Maryam Mahmoudi

 Download the PDF from Sci-Hub VitaminDWiki

Introduction
As a primary headache, migraine has been established as the first leading disability cause worldwide in the subjects who aged less than 50 years. A variety of dietary supplements have been introduced for migraine complementary treatment. As an anti-inflammatory and antioxidant agent, vitamin D is one of these agents which has been of interest in recent years. Although higher prevalence of vitamin D deficiency/insufficiency has been highlighted among migraineurs compared to controls, there is not any consensus in prescribing vitamin D in clinical practice. Therefore, in the current review, in addition to observational and case-control studies, we also included clinical trials concerning the effects of vitamin D supplementation on migraine/headache.

Methods
Based on a PubMed/MEDLINE and ScienceDirect database search, this review study includes published articles up to June 2019 concerning the association between migraine/headache and vitamin D status or supplementation.

Results
The percentage of subjects with vitamin D deficiency and insufficiency among migraineurs and headache patients has been reported to vary between 45 and 100%. In a number of studies, vitamin D level was negatively correlated with frequency of headaches. The present findings show that supplementation with this vitamin in a dose of 1000–4000 IU/d could reduce the frequency of attacks in migraineurs.

Conclusion
It seems a high proportion of migraine patients might suffer from vitamin D deficiency/insufficiency. Further, the current evidence shows that in addition to routine drug therapy, vitamin D administration might reduce the frequency of attacks in migraineurs. However, these results have yet to be confirmed.

Created by admin. Last Modification: Tuesday August 6, 2019 17:57:47 GMT-0000 by admin. (Version 3)

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12427 Migraine Sci-Hub July 2019.pdf PDF 2019 admin 06 Aug, 2019 17:53 449.50 Kb 20
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