Vitamin D and the kidneys: a fascinating relationship – EDITORIAL
J. Bras. Patol. Med. Lab. vol.51 no.5 Rio de Janeiro Sept./Oct. 2015, http://dx.doi.org/10.5935/1676-2444.20150045
José Gilberto Henriques Vieira 1
1Escola Paulista de Medicina da Universidade Federal de São Paulo (EPM/Unifesp)
The complexity of the physiological system that controls serum calcium levels is remarkable. In the Figure we present a very simplified view of this system, stressing the crucial role of vitamin D and the kidneys in the overall complex. No wonder, the system without normal renal function turns out to be highly deranged. Chronic kidney disease (CKD) is, unfortunately, very frequent, and metabolic bone disease, the result of specific alterations in calcium and phosphorus metabolism, one of its main complications(1). The availability of kidney transplantation provided a real step forward in CKD patients' survival and quality of life. For the majority of transplant patients, a return to nearly normal renal function is the more likely result(2).
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Kidney Intervention trials using Vitamin D:
- Fracture 4X less likely following kidney transplant if high-dose Vitamin D (100,000 every 2 weeks) – RCT Jan 2023
- Hyperparathyroidism resulting from CKD eliminated by 8,000 IU of vitamin D daily for 12 weeks– RCT 2018
- Bone biomarkers increased equally by daily, weekly, or monthly Vitamin D (CKD in children in this case) – Nov 2022
- Vitamin D treatment of Chronic Kidney Disease: monthly better than daily – RCT May 2022
- 1,000 IU of vitamin D provides little benefit (Kidney transplant in this case) – April 2021
- Kidney patients who happened to be getting high-dose Calcitriol were 9X less likely to die of COVID-19 - April 6, 2021
- Chronic Kidney Disease (stage 3) slowed by 30 ng of Vitamin D and Calcitriol – Dec 2019
- Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
- Hemodialysis patients (CKD) helped by weekly 50,000 IU of vitamin D – Jan 2017
- Kidney disease helped by active or high dose Vitamin D - Feb 2014
- Peritoneal Dialysis nicely treated by active vitamin D – July 2013
- 7100 IU (50000 weekly) restored vitamin D levels for those with Chronic Kidney Disease – July 2012
- Chronic Kidney Disease reduced with 3600 IU vitamin D (50000 twice a month)– RCT Aug 2012
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