Fluoridation results in lower IQ, Magnesium, and Vitamin D - many studies

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13+ VitaminDWiki pages have FLUOR in the title

This list is automatically updated

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Is Water Fluoridation Safe? - Dr. Greger May 2024 (No! - substantially lowers IQ)

5 minute video
Fluoride had been found to be a developmental neurotoxin in rats and mice, leading to learning and memory deficits, which led to an interest in studying human populations. Starting in the 1980s, reports started appearing in Chinese medical journals that found correlations between areas naturally containing higher fluoride levels in water with lower intelligence among children. Dental fluorosis, the fluoride-induced tooth mottling, is widespread in China, with more than 90 million residents affected, often in small pockets surrounding particular small springs or mountain sources. Researchers took advantage of the fact that even adjoining neighborhoods could have wildly different fluoride exposure, setting up a type of natural experiment.

Due to limited access to Chinese journals at the time, these studies largely escaped the attention of scientists in the West until a meta-analysis of 16 such studies was published in English in 2008. “Fluoride and Children’s Intelligence: A Meta-analysis” found that children living in areas prone to fluorosis had five times higher odds of developing low IQ than those living in areas with little or no fluorosis. So, here we were, thinking dental fluorosis was just a cosmetic blemish, but it may instead be a visual indicator of intellectual deficits.
A subsequent meta-analysis in 2012 including about 10 more studies found that the average intelligence gap between high- and low-fluoride exposure areas was about seven IQ points. By far the largest study, involving thousands of children, found that even at fluoride levels below 1 ppm, higher fluoride levels were associated with a large drop in the chances of developing excellent intelligence (defined as an IQ of 130 or higher). Even very mild fluorosis was associated with less than half the odds of reaching such a high IQ.

By now, there have been more than 50 studies showing an association between higher fluoride exposure and lower IQ. In the latest systematic review and meta‑analysis, 90 percent of the studies published in the last ten years reported a link between high fluoride exposure and reduced intelligence. However, serious caveats are in order.

First, the fluoride concentrations in most of these studies were well above fluoridation levels. In the 2012 meta-analysis, for example, one study clocked concentrations as high as 11.5 ppm, far exceeding the U.S. target of 0.7 parts per million, as well as the average concentration in the United States, which is around 0.8 ppm in municipal water and 0.3 ppm in well water. Now, to be fair, the 11.5 ppm in the meta-analysis was an outlier. The average elevated level was only about two parts per million, and most found associated IQ decrements below the EPA’s upper limit, its Maximum Contaminant Level Goal of four ppm, which is supposed to represent the level “below which there is no known or expected risk to health.”

Some studies showed lower intelligence with fluoride concentrations even down at one to two ppm, with one estimate suggesting the smallest harmful concentration, potentially shaving off a single IQ point, would be down around 0.3 ppm––assuming you drink four cups of water a day, while others suggest it’s too early to be able to calculate a threshold for human neurotoxicity due to insufficient available data.

The second major caveat is confounding. Nearly all of the studies to date have been performed in rural communities in countries like China, Iran, and Mongolia. Areas within these countries with unusually high fluoride levels may be particularly poor and underdeveloped, since relatively rich communities may be more likely to invest in higher-quality drinking water that filters out fluoride, if only to reduce dental fluorosis. High-fluoride water may also be more likely to be contaminated with other neurotoxins. Fluoride exists in water as a negatively charged particle. To maintain electroneutrality, this may pull into the groundwater positively charged particles such as aluminum, arsenic, lead, or mercury. This doesn’t happen in community water fluoridation, since the negative fluoride ions are balanced out in the water treatment process.

Finally, most of the older studies were cross-sectional and ecological, meaning they looked at a snapshot-in-time of group level data, rather than individual-exposures-over-time. Just because a child with low IQ lives in a high-fluoride area doesn’t necessarily mean they or their mom actually drank the water, for example. Ideally, we’d be able to measure individual exposure levels and then follow the kids over time to see if those with higher exposure really do grow up with stunted intellects. And that’s exactly what we’ll cover in my next video, entitled “Why I Changed My Mind on Water Fluoridation.”

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Why I Changed My Mind on Water Fluoridation - Dr. Greger May 2024

Link to video
References for the video:

• Amiri A. Water fluoridation: When current research contradicts public practices. Public Health Nurs. 2020;37(4):475-477.
• Gravitz L. The fluoride wars rage on. Nature. Oct 2021.
• Grandjean P. Developmental fluoride neurotoxicity: an updated review. Environ Health. 2019;18(1):110.
• Valdez Jiménez L, López Guzmán OD, Cervantes Flores M, et al. In utero exposure to fluoride and cognitive development delay in infants. Neurotoxicology. 2017;59:65-70.
• Bashash M, Thomas D, Hu H, et al. Prenatal fluoride exposure and cognitive outcomes in children at 4 and 6-12 years of age in Mexico. Environ Health Perspect. 2017;125(9):097017.
• Green R, Lanphear B, Hornung R, et al. Association between maternal fluoride exposure during pregnancy and IQ scores in offspring in Canada. JAMA Pediatr. 2019;173(10):940-948.
• How much water should I drink during pregnancy? ACOG. Oct 2020.
• Community Water Fluoridation Exposure: A Review of Neurological and Cognitive Effects – A 2020 Update. CADTH; 2020.
• Bellinger DC. Is fluoride potentially neurotoxic? JAMA Pediatr. 2019;173(10):915-917.
• Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services. Draft NTP monograph on the systematic review of fluoride exposure and neurodevelopmental and cognitive health effects. ASDWA. Sept 2019.
• Till C, Green R. Controversy: The evolving science of fluoride: when new evidence doesn’t conform with existing beliefs. Pediatr Res. 2021;90(5):1093-1095.
• National Academies of Sciences, Engineering, and Medicine; Division on Earth and Life Studies; Board on Environmental Studies and Toxicology; Exposure and Neurodevelopmental and Cognitive Health Effects; *Committee to Review the NTP Monograph on the Systematic Review of Fluoride. Review of the Draft NTP Monograph: Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects. Washington (DC): National Academies Press (US); 2020.
• Lennon MA. IQ research discredited. Br Dent J. 2020;229(2):75.
• Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services. *Draft NTP monograph on the systematic review of fluoride exposure and neurodevelopmental and cognitive health effects*. Sept 2020.
• National Academies of Sciences, Engineering, and Medicine. Review of the Revised NTP Monograph on the Systematic Review of Fluoride Exposure and Neurodevelopmental and Cognitive Health Effects: A Letter Report. Washington, DC: National Academies Press; 2021

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As of May 2000, 42 of the 50 largest U.S. cities had water fluoridation

Perplexity AI - May 2024

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VitaminDWiki – Interactions with Vitamin D contains

Interactions with Vitamin D has 123 items

Various drugs decrease Vitamin D
Drug interactions with Vitamin D - many studies - Feb 2024
Antidepressants reduce cellular Vitamin D, increasing fractures, CVD, etc. - Oct 2022
Medications that appear to lower Vitamin D – Aug 2021
24 drugs that typically reduce Vitamin D levels – Review Aug 2021
Proton pump inhibitors decrease Vitamin D and Magnesium – Dec 2018
Statins and Vitamin D - many studies
Glyphosate decreases Vitamin D getting to cells in many ways
Antibiotics and Vitamin D are associated with many of the same diseases
More colas lower vitamin D by 3 ng– July 2014
A few Drugs increase Vitamin D
Contraceptives,   Probiotics
Vitamin D can decrease/increase impact of drugs
be careful of Chemotheraphy and Vitamin D
Vitamin D generally improves the efficacy of drugs while reducing their adverse effects – Jan 2020
Some Drugs decrease Vitiamin D co-factors or limit vitamin D getting to cells
Drugs which create deficiencies in Vitamin D, Vitamin K, Magnesium, Zinc, Iron, etc. – Sept 2017
Drugs Deplete Magnesium
Interaction of drugs with Vitamin D cofactors
Non-drugs also decrease vitamin D levels in blood and cells
Plastics, BPA, PCB and Vitamin D deficiency
Air pollution, toxins, heavy metals and smoking each result in lower Vitamin D levels – Nov 2018
Air Pollution reduces Vitamin D production - many studies
Pesticides increase risk of Cancers, Alz, ALS, Asthma, ADHD, etc. (all related to low vitamin D) – Oct 2016
Smoking   Coffee
Cooked dried beans or peas

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Far more vitamin D deficiency if high fluoride in water - Jan 2021

   Click here for details