Vitamin D in pregnancy: understanding immune effects in the decidua
Tamblyn, Jennifer Ann (2018) , Ph.D. thesis, University of Birmingham.
I wonder if the decidua is actually larger (and perhaps activate more VitaminD) than the placenta?
See also VitaminDWiki
- Miscarriages strongly associated with poor placental, decidua gene which locally activates Vitamin D – Dec 2016
- Recurrent miscarriage associated with half as much vitamin D getting to fetus – Sept 2016
- Both the placenta and decidua, like most tissues, are able to activate vitamin D without the need for a Kidney
- Vitamin D helps women in many ways – review April 2015
- IVF 4X more successful for white women with lots of vitamin D – many studies
- Vitamin D and Human Reproduction – 51 page chapter – April 2017
- Overview Pregnancy and vitamin D
Pregnancy category starts with
- see also
- Overview Pregnancy and vitamin D
- Number of articles in both categories of Pregnancy and:Dark Skin
30 ; Depression 21 ; Diabetes 44 ; Obesity 17 ; Hypertension 44 ; Breathing 35 ; Omega-3 44 ; Vitamin D Receptor 24 Click here for details - All items in category Infant/Child
854 items - Pregnancy needs at least 40 ng of vitamin D, achieved by at least 4,000 IU – Hollis Aug 2017
- 38+ papers with Breastfed etc, in the title
- Call to action – more Vitamin D for pregnancies, loading doses are OK – Holick Aug 2019
- 53+ preeclampsia studies
- 94+ studies with PRETERM in the title
- Fertility problem (PCOS) reduced by vitamin D, etc: many studies 15+
- 94+ Gestational Diabetes
- Caesarean birth much more likely if low Vitamin D - many studies 15+ studies
- Post-partum depression and low Vitamin D - many studies 15+ studies
- Stillbirth reduced by Vitamin D, Zinc, Omega-3 - several studies 5+ studies
- Search VitaminDWiki for "Assisted reproduction" 33 items as of Aug 2022
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142 items along with related searches - (Stunting OR “low birth weight” OR LBW) 1180 items as of June 2020
- Less labor pain if higher level of vitamin D – August 2021
- Healthy pregnancies need lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
Healthy pregnancies need lots of vitamin D has the following summary
Most were taking 2,000 to 7,000 IU daily for >50% of pregnancy
Click on hyperlinks for detailsProblemVit. D
ReducesEvidence 0. Chance of not conceiving 3.4 times Observe 1. Miscarriage 2.5 times Observe 2. Pre-eclampsia 3.6 times RCT 3. Gestational Diabetes 3 times RCT 4. Good 2nd trimester sleep quality 3.5 times Observe 5. Premature birth 2 times RCT 6. C-section - unplanned 1.6 times Observe Stillbirth - OMEGA-3 4 times RCT - Omega-3 7. Depression AFTER pregnancy 1.4 times RCT 8. Small for Gestational Age 1.6 times meta-analysis 9. Infant height, weight, head size
within normal limitsRCT 10. Childhood Wheezing 1.3 times RCT 11. Additional child is Autistic 4 times Intervention 12.Young adult Multiple Sclerosis 1.9 times Observe 13. Preeclampsia in young adult 3.5 times RCT 14. Good motor skills @ age 3 1.4 times Observe 15. Childhood Mite allergy 5 times RCT 16. Childhood Respiratory Tract visits 2.5 times RCT RCT = Randomized Controlled Trial
See also PubMed
- Vitamin D, the placenta and early pregnancy: effects on trophoblast function Feb 2018
Ganguly A1, Tamblyn JA1,2,3, Finn-Sell S4, Chan SY5, Westwood M4, Gupta J1,2, Kilby MD1,2, Gross SR6, Hewison M7,3.
Free PDF online doi: 10.1530/JOE-17-0491 - Women with recurrent spontaneous abortion have decreased 25(OH) vitamin D and VDR at the fetal-maternal interface Sep 2017, free PDF online
- Immunological function of vitamin D during human pregnancy Aug 2017 doi: 10.1111/aji.12716
Download the PDF from VitaminDWiki
Epidemiology has linked preeclampsia (PET) to vitamin D deficiency. To date, studies have focused upon serum 25-hydroxyvitamin D3 (25(0H. )D3) alone as the marker of vitamin D status.~We provide strong evidence comprehensive analysis of vitamin D metabolites in pregnancy is highly informative, particularly within the context of PET. Uniquely, analysis of maternal urinary metabolites provides a novel insight into vitamin D and the kidney, with lower 25(0H)D3 and 24,25(0H)2D3 excretion early indicators of a predisposition towards PET.
Since vitamin D is a potent regulator of immune function, and the decidua appears a key extra-renal site for vitamin D metabolism, we investigated effects of 1 ,25(0H)2D3 upon decidual uterine natural killer cells and macrophages. We show both express a functional vitamin-D system and demonstrate differential sensitivity to 1 ,25(0H)2D3 compared to their peripheral counterparts.
To understand the functional impact of vitamin D, whole transcriptomic analysis of 1,25(0H)2D3-mediated effects upon uNK and macrophages was performed. We show the actions of vitamin D extend far beyond simple immuno-regulation, targeting major cellular functions including migration, adhesion and apoptosis. In particular, our data support effects highly relevant to decidualisation.
We anticipate these findings to be highly relevant within the context of vitamin D deficiency, mal placentation and PET.
Dissertation includes portions of 5 of her publications
- Tamblyn JA, Hewison M, Wagner CL, Bulmer JN, Kilby MD. Immunological role of vitamin D at the maternal-fetal interface. J Endocrinol. 2015; 224(3):R107-21(71). http://dx.doi/org/10.1530/JOE-14-0642
- Tamblyn JA, Susarla R, Jenkinson C, Jeffery L, Ohizua O, Chun R, Chan S, Kilby M, Hewison M. Dysregulation of Maternal and Placental Vitamin D Metabolism in Preeclampsia. Placenta 50, 70-77.2016 (104). http://dx.doi/org/10.1016/j.placenta.2016.12.019
- Tamblyn J, Jenkinson C, Larner D, Hewison M, Kilby M. Serum and urine vitamin D metabolite analysis in early preeclampsia. Endocr Connect. 2017; pii: EC-17-0308 (105). http://dx.doi/org/10.1530/EC-17-0308
- Liu NQ, Larner D, Yao Q, Chun R, Zhou R, Tamblyn JA, Wagner C, Hewison M. Vitamin Ddeficiency and sex-specific dysregulation of placental inflammation. Journal of Steroid Biochemistry and Molecular Biology 2017; S0960-0760(17)30163-2(505). http://dx.doi/org/10.1016/j.jsbmb.2017.06.012
- Powell R, Lissauer D, Tamblyn J, Beggs A, Cox P, Moss P, Kilby M. Decidual T cells exhibit a highly differentiated phenotype and demonstrate potential fetal-specificity and a strong transcriptional response to interferon. Journal of Immunology 2017; 199(10):3406-3417 (234) http://dx.doi/org/10.4049/jimmunol.1700114
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