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Decidua immunity and Vitamin D – dissertation July 2018

Vitamin D in pregnancy: understanding immune effects in the decidua

Tamblyn, Jennifer Ann (2018) , Ph.D. thesis, University of Birmingham.

VitaminDWiki

I wonder if the decidua is actually larger (and perhaps activate more VitaminD) than the placenta?
Image


See also VitaminDWiki


Pregnancy category starts with

704 items in Pregnancy category

 - see also


Healthy pregnancies need lots of vitamin D has the following summary

Problem
ReducesEvidence
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
RCT
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial


See also PubMed

 Download the PDF from VitaminDWiki

Epidemiology has linked preeclampsia (PET) to vitamin D deficiency. To date, studies have focused upon serum 25-hydroxyvitamin D3 (25(0H. )D3) alone as the marker of vitamin D status.~We provide strong evidence comprehensive analysis of vitamin D metabolites in pregnancy is highly informative, particularly within the context of PET. Uniquely, analysis of maternal urinary metabolites provides a novel insight into vitamin D and the kidney, with lower 25(0H)D3 and 24,25(0H)2D3 excretion early indicators of a predisposition towards PET.

Since vitamin D is a potent regulator of immune function, and the decidua appears a key extra-renal site for vitamin D metabolism, we investigated effects of 1 ,25(0H)2D3 upon decidual uterine natural killer cells and macrophages. We show both express a functional vitamin-D system and demonstrate differential sensitivity to 1 ,25(0H)2D3 compared to their peripheral counterparts.

To understand the functional impact of vitamin D, whole transcriptomic analysis of 1,25(0H)2D3-mediated effects upon uNK and macrophages was performed. We show the actions of vitamin D extend far beyond simple immuno-regulation, targeting major cellular functions including migration, adhesion and apoptosis. In particular, our data support effects highly relevant to decidualisation.

We anticipate these findings to be highly relevant within the context of vitamin D deficiency, mal placentation and PET.

Dissertation includes portions of 5 of her publications

  • Tamblyn JA, Hewison M, Wagner CL, Bulmer JN, Kilby MD. Immunological role of vitamin D at the maternal-fetal interface. J Endocrinol. 2015; 224(3):R107-21(71). http://dx.doi/org/10.1530/JOE-14-0642
  • Tamblyn JA, Susarla R, Jenkinson C, Jeffery L, Ohizua O, Chun R, Chan S, Kilby M, Hewison M. Dysregulation of Maternal and Placental Vitamin D Metabolism in Preeclampsia. Placenta 50, 70-77.2016 (104). http://dx.doi/org/10.1016/j.placenta.2016.12.019
  • Tamblyn J, Jenkinson C, Larner D, Hewison M, Kilby M. Serum and urine vitamin D metabolite analysis in early preeclampsia. Endocr Connect. 2017; pii: EC-17-0308 (105). http://dx.doi/org/10.1530/EC-17-0308
  • Liu NQ, Larner D, Yao Q, Chun R, Zhou R, Tamblyn JA, Wagner C, Hewison M. Vitamin Ddeficiency and sex-specific dysregulation of placental inflammation. Journal of Steroid Biochemistry and Molecular Biology 2017; S0960-0760(17)30163-2(505). http://dx.doi/org/10.1016/j.jsbmb.2017.06.012
  • Powell R, Lissauer D, Tamblyn J, Beggs A, Cox P, Moss P, Kilby M. Decidual T cells exhibit a highly differentiated phenotype and demonstrate potential fetal-specificity and a strong transcriptional response to interferon. Journal of Immunology 2017; 199(10):3406-3417 (234) http://dx.doi/org/10.4049/jimmunol.1700114
Created by admin. Last Modification: Saturday July 28, 2018 15:19:23 GMT-0000 by admin. (Version 9)

Attached files

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10249 Decidua.jpg admin 28 Jul, 2018 13:31 46.35 Kb 20546
10248 immune effects in the decidua.pdf PDF 2018 admin 28 Jul, 2018 13:08 4.12 Mb 384
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