Front. Immunol. | doi: 10.3389/fimmu.2016.00697
Wendy Dankers1, Edgar M. Colin2, Jan Piet Van Hamburg1 and Erik Lubberts1*
1Rheumatology and Immunology, Erasmus MC, University Medical Center, Netherlands
2Rheumatology, ZGT, Netherlands
Over the last three decades it has become clear that the role of vitamin D goes beyond the regulation of calcium homeostasis and bone health. An important extra-skeletal effect of vitamin D is the modulation of the immune system. In the context of autoimmune diseases, this is illustrated by correlations of vitamin D status and genetic polymorphisms in the vitamin D receptor with the incidence and severity of the disease. These correlations warrant investigation into the potential use of vitamin D in the treatment of patients with autoimmune diseases.
In recent years several clinical trials have been performed to investigate the therapeutic value of vitamin D in
- multiple sclerosis,
- rheumatoid arthritis,
- Crohn’s disease,
- type I diabetes and
- systemic lupus erythematosus.
Additionally, a second angle of investigation has focused on unraveling the molecular pathways used by vitamin D in order to find new potential therapeutic targets. This review will not only provide an overview of the clinical trials that have been performed, but also discuss the current knowledge about the molecular mechanisms underlying the immunomodulatory effects of vitamin D and how these advances can be used in the treatment of autoimmune diseases.
Autoimmune category starts with
200 items in Autoimmune category - Vitamin D and MS Asthma RA Diabetes Gut Allergy Hay Fever Lupus Psoriasis
- Predicted 95% autoimmune cured by HIGH-DOSE vitamin D - 2014
- 10% of the UK have Autoimmune Diseases - Lancet May 2023 PDF is behind a paywall
- Increase in 20 years : coeliac disease 2.19 X. Sjogren's syndrome 2.09, and Graves' disease 2.07
- All 43 references are FREE on-line
- Autoimmune diseases fought by Vitamin D, especially if have more than 40 ng – Sept 2022
- The BEST Nutrient for Autoimmune Conditions (Vitamin D) - video May 2022
- The number 1 Deficiency behind All Autoimmune Diseases (Vitamin D) video - Dec 2023
- Autoimmune disease clusters run in families having low D
- How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
- 120 doctors and 20,000 MS patients using high dose Vitamin D Dec 2018
- Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018
- Vitamin D Receptor is associated in over 58 autoimmune studies
- More autoimmune disease if higher pollution or lower UVB - Feb 2023
- Many autoimmune diseases associated with low vitamin D or poor Vit D genes – July 2019
See also web: consensus that ~50 diseases are autoimmune, ~50 more are suspected:
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