Topical Vitamin D provides more benefits than oral sometimes - many studies

It appears that ~10% of people will benefit from Topical more than the Oral form of Vitamin D
It appears that ~20% of people having specific health problems will get more benefit from Topical than Oral

• Preeclampsia. Food Allergy, PTSD, Ear infection, Infertility, MS, Colon Cancer, TB, Asthma, COPD, Epilepsy, Atrial Fibrillation. Liver
• Also suspect for those people with poor guts: Cystic Fibrosis, Diabetes

However, Topical forms of Vitamin D are:

• 10X-100X more expensive
• Harder to use than oral for most people
• Do not easily allow high doses - for loading doses or non daily dosing (biweekly etc)
  • Vitamin D cream might be OK - 5 squirts of cream = 50,000 IU

Most body tissues can fully activate Vitamin D locally (without the Liver and Kidneys)
   Tissues such as the skin, the inside of the cheeks, the lungs, and the nose
Some people have a poor vitamin D binding gene

• Limits the amount of semi-activated Vitamin D from the liver
• The vitamin D binding gene does not appear to limit vitamin D that is activated by tissue

An increasing number of people have poor Vitamin D genes

• Starting in the 1930's people with poor immune systems have been surviving due to better hygiene, antibiotics, vaccines, etc.
• Since then, poor immune system genes have more frequently been passed on to future generations
• Before there was "Survival of the Fittest", but there is "Survival of the Survivors"

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43 reasons for Vitamin D deficiency includes the following chart

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VitaminDWiki – Topical Vitamin D category contains

Topical is one of the many ways of increasing the vitamin D in your body
Topical is 2X to 50X more expensive than oral form
Topical is great for those who not want to swallow pillls nor fortifiy their food/drink with Vitamin D
Topical is one of the many gut-friendly forms of vitamin D (good bioavailability for those with poor guts
Topical is especially good form to apply directly to skin problems:
    - i.e. Psoriasis  Warts  Burns  Acne  Eczema  Wounds  (lasts about a day)
    The skin, like most tissues of the body, can fully-activate Vitamin D locally - no liver nor kidney needed.
Provides perhaps 100X higher concentration of Vitamin D to that portion than if same dose were taken orally
There were 98 topical Vitamin D products on Amazon Sept 2024 Creams, oils, patches, nanoemulsions, etc.
   I prefer Nutrasal nanoemulsion form
Suspect that topical Vitamin D is best absorbed where the skin gets Vitamin D naturally
- - - face and hands vs the back or the inside of arms
Nanoemulsions can also be applied topically under the tongue and inhaled

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Topical Vitamin D sources include:

• Sun
• UV - sunbed or make UV lamp at home
• Topical Vitamin D oil
• Topical Vitamin D cream Amazon 10.000 IU   Amazon 15,000 IU
• Topical Vitamin D water (open up and dissolve 50,000 IU powder in 1/2 tsp of water)
  • Keep Vitamin D water under tongue for a few minutes
  • Apply Vitamin D water to skin
• Spray inside of the cheek or on the skin Amazon 100+ companies Oct 2019
• Vitamin D patches Amazon, 5,000 IU in 8 hours
• Inhaled Vitamin D - make at home

Note: Topical Vitamin D may also be BETTER than most oral forms if you:

• Have Gut problems
• Dislike swallowing pills
• Have a low/poor blood level response to vitamin D supplementation- e.g., poor CYP27A1 gene (in your liver)
• Have poor Vitamin D Binding Protein (in your blood)

Vitamin D Binding Protein category in VitaminDWiki has 180 items and starts with:

Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,

• GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
• The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
• The actual D getting to the cells is a function of measured D and all 4 genes
• There is >2X increase in 8+ health problems if have poor VDBP (GC)
• It appears that VDBP only blocks oral vitamin D,
  • but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
  • A clue: - Vitamin D from UV is 2X better for MS than oral Vitamin D

Vitamin D Binding Protein list of health problems includes:
   Preeclampsia, Food Allergy, PTSD, Poor Response to Oral Vitamin D, Ear infection, Multiple Sclerosis, Colorectal Cancer, Prostate Cancer - blacks,
   Infertility. TB, Asthma, COPD, Epilepsy, Atrial Fibrilation, and Obesity

Getting Vitamin D into your blood and cells shows all of the  sources

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Note: Vitamin D Binding protein does NOT restrict topical or sublinqual Vitamin D

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Mystery of why UVB is better than oral supplementation resolved after 7 years

• A 2012 study found that:
  Vitamin D blood levels produced by UV were 2X better for MS than those from supplements
• For years people speculated that the Sun/UVB produced something in addition to Vitamin D
• But, studies have found many health problems, such as MS. to be assocated with poor genes:
  MS studies and Vitamin D Binding Protein (7), Vitamin D Receptor (16), Genes (22)
• Mystery solved: Oral and topical sources will produce same blood level, but topical will get more activated vitamin D to the tissues if poor VDBP

Remaining mystery: Why does Vitamin D from UV last 2X longer in the body than from oral sources

• Might there be a better storage location for UV or topical Vitamin D in tissue (muscle?)
• Might non-UV, topical sources also have a 2X longer half-life in the body?

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TOP articles in Forms of Vitamin D:

4 Reasons why you have not heard that Vitamin D is good for the skin:

1) Vitamin D has been patented to help the skin - and companies do not want to pay royalties

• WO/2006/133829 USE OF 25-HYDROXY-VITAMIN D3 - cream for many skin problems
• (WO/2006/094064) Sept 2006 METHOD OF REDUCING SCARS WITH VITAMIN D
• WO/2011/019617 VITAMIN D3 AND ANALOGS THEREOF FOR TREATING ALOPECIA - delivered to the skin March 2011
• Who said vitamin D could not be patented - VitaminDWiki
  • A patent is one of the 22 Criteria to associate a health problem with low vitamin D in VitaminDWiki

2) FDA requires a LOT of data to allow a claim that a supplement can improve health
It appears to cost >$30,000 to prepare, present, and defend a single health claim for a supplement

• FDA allows the claim that Vitamin D “supports healthy pregnancies and promotes full-term births” – Oct 2019
• FDA allows 2 specific Vitamin D and 2 Omega-3 health claims - 2019

3) Only recently have Vitamin D doses been large enough to really help (200X)

	< year 2000	2019	increase
Drops	10 IU/drop	2,000 IU	200X
Capsule	200 IU	50,000 IU	250X

4) Doctors rarely suggest applying the Vitamin D directly to the skin
They often incorrectly believe that the Vitamin D must be first processed by the liver and the kidneys

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