Maternal Early-Pregnancy Vitamin D Status Is Associated With Maternal Depressive Symptoms in the Amsterdam Born Children and Their Development Cohort
Psychosomatic Medicine August 9, 2012 PSY.0b013e3182639fdb Joke Brandenbarg, MSc, Tanja G.M. Vrijkotte, PhD, Geertje Goedhart, PhD and Manon van Eijsden, PhD mveijsden@ggd.amsterdam.nl
From the Department of Epidemiology, Documentation, and Health Promotion (J.B., M.v.E.), Public Health Service; Department of Health Sciences (M.v.E.), VU University; and Department of Public Health (T.G.M.V.), Academic Medical Center, University of Amsterdam, Amsterdam; and Institute for Risk Assessment Sciences (G.G.), University of Utrecht, Utrecht, the Netherlands.
Objective To examine low maternal vitamin D status as a potential risk factor for high levels of depressive symptoms in a pregnant population.
Methods In the Amsterdam Born Children and Their Development cohort, maternal serum vitamin D (n = 4236) was measured during early pregnancy (median, 13 weeks) and labeled “deficient” (?29.9 nM), “insufficient” (30–49.9 nM), “sufficient” (50–79.9 nM), and “normal” (?80 nM). Maternal depressive symptoms were measured by the Center for Epidemiological Studies Depression Scale at 16-week gestation. The association of vitamin D status with high levels of depressive symptoms (Center for Epidemiological Studies Depression score ?16) was assessed by multivariate logistic regression (final sample, 4101).
Results Overall, 23% of women had vitamin D deficiency, and 21% of women had vitamin D insufficiency. Women with high levels of depressive symptoms (28%) had lower vitamin D concentrations than women with low levels of depressive symptoms (p < .001).
After adjustment for constitutional factors, life-style and psychosocial covariates, and sociodemographic factors, vitamin D deficiency (odds ratio [OR], 1.48; 95% confidence interval [CI], 1.13–1.95) and insufficiency (OR, 1.44; 95% CI, 1.12–1.85) were significantly associated with high levels of depressive symptoms.
Additional analyses revealed a linear trend, with an OR of 1.05 (95% CI, 1.02–1.08) for each 10-nM decrease in vitamin D status.
Conclusions In this study, low early-pregnancy vitamin D status was associated with elevated depressive symptoms in pregnancy. Further research, using a randomized controlled design, would be required to confirm the causality of this association and the potential benefits of higher vitamin D intake for psychosocial health.
Summary by VitaminDWiki
- <12 nanograms of vitamin D: 48% more likely to be depressed
- 12-25 nanograms of vitamin D: 44% more likely to be depressed
See also VitaminDWiki
- Psychosis in dark skinned people 3.5 X higher if low level of vitamin D – May 2012
- Less than 20 ng vitamin D increases depression by 80 percent – Dec 2010
- Overview Pregnancy and Vitamin D
- All items in depression and vitamin D
268 items - Pregnant blacks 50 pcnt more likely to be depressed if 3 ng lower vitamin D – July 2012
- Much less depression if more than 43 ng of vitamin D – Oct 2012
- Antidepressants might increase infertility and pregnancy problems – Nov 2012
- Depression during pregnancy twice as likely if consume little vitamin D – July 2014
Iitems tagged in both categories Depression AND Pregnancy- Post-partum depression and low Vitamin D - many studies
- Postpartum depression 3.6 X higher risk if low vitamin D – Jan 2022
- ADHD 3.7 X higher risk if depressed pregnancy (low vitamin D) – Dec 2020
- Depression after childbirth 5 X less likely if good Omega-3 index – April 2019
- Postpartum Depression 3.3 X more likely if low vitamin D – Oct 2018
- Vitamin D prevents pregnancy depression (US Prevention Task Force say it cannot be prevented) - Feb 2019
- Depressed black pregnant women should take vitamin D – April 2018
- Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017
- Perinatal depression decreased 40 percent with just a few weeks of 2,000 IU of vitamin D – RCT Aug 2016
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Depression in youths associated with low vitamin D during pregnancy – Oct 2014
- Postpartum depression 7X more likely if less than 10 ng of vitamin D – Sept 2014
- Depression after pregnancy and vitamin D – Nov 2013
- Depression and Vitamin D during Pregnancy – Dissertation Aug 2014
- Depression during pregnancy twice as likely if consume little vitamin D – July 2014
- Antidepressants might increase infertility and pregnancy problems – Nov 2012
- Association between season of birth and suicide – perhaps vitamin D – Sept 2012
- Depression 50 percent more likely if low vitamin D in early pregnancy – Aug 2012
- Pregnant blacks 50 pcnt more likely to be depressed if 3 ng less vitamin D – July 2012
- Depressed mothers more likely to have small babies – Aug 2010
- An Exploratory Study of Postpartum Depression and Vitamin D - May 2010
See also web
- Depression ==> premature birth 96% increase in premature birth if ani-depressants in late pregnancy; April 2014
No mention of low vitamin D
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