COVID virus alters the activation of 100 vitamin D related genes in the lung – April 2021

Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient's lung cells

Sci Rep . 2021 Apr 21;11(1):8570. doi: 10.1038/s41598-021-87703-z.
Bijesh George 1 2, Revikumar Amjesh 1, Aswathy Mary Paul 1 2, T R Santhoshkumar 1, Madhavan Radhakrishna Pillai 3, Rakesh Kumar 4 5 6

Up and Down regulation (One of scores of charts in the PDF)

VitaminDWiki

This preprint of this study was reviewed in Medical News Net Dec 22, 2020

Health problems that have learned to de-regulate the Vitamin D metabolism require higher blood levels of Vitamin D
COVID-19 affects the CYP27A1 gene, which results in less Vitamin D to be produced in the blood
The CYP27A1 gene can be bypassed in two ways
- Topical or mucosal Vitamin D - dissolve Vitamin D powder in water or use nanoemulsion
- Semi-activated Vitamin D (Calcidiol) which was found to be very successful in one clinical trial
  - Note: Calcidiol is high cost and prescription-only for humans, but is available at low cost to animal doctors
There are 10+ ways to increase the Vitamin D Receptor activation

Genetics category listing contains the following

343 articles in the Genetics category

see also

Vitamin D Receptor has 529 items
Vitamin D Binding Protein = GC has 177 items
CYP27B1 has 63 items
CYP24A1 in title of 34+ items
CYP2R1 25+ items
Calcidiol has 48 items
Calcitriol has 61 items
Topical Vitamin D
Nanoemulsion Vitamin D may be a substantially better form
1289 genes changed with higher doses of Vitamin D - RCT Dec 2019
CYP3A4 (7 as of Dec 2022)
Getting Vitamin D into your body

Vitamin D blood test misses a lot
in Visio for 2023

Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
A Vitamin D test in cells rather than blood was feasible (2017 personal communication) Commercially available 2019
- However, test results would vary in each tissue due to multiple genes
Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family
    especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D shows benefits (even if conventional Vitamin D test shows an increase)
3) DNA and VDR tests - 120 to 200 dollars $100 to $250
4) PTH bottoms out ( shows that parathyroid cells are getting Vitamin d)
   Genes are good, have enough Magnesium, etc.
5) Back Pain
   probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc

VitaminDWiki - Vitamin D Receptor deactivated by some health problems - many studies

Download the PDF from VitaminDWiki
Table of contents

Although a defective vitamin D endocrine system has been widely suspected to be associated in SARS-CoV-2 pathobiology, the status of the vitamin D endocrine system and vitamin D-modulated genes in lung cells of patients infected with SARS-CoV-2 remains unknown. To understand the significance of the vitamin D endocrine system in SARS-CoV-2 pathobiology, computational approaches were applied to transcriptomic datasets from bronchoalveolar lavage fluid (BALF) cells of such patients or healthy individuals. Levels of vitamin D receptor, retinoid X receptor, and CYP27A1 in BALF cells of patients infected with SARS-CoV-2 were found to be reduced. Additionally, 107 differentially expressed, predominantly downregulated genes, as potentially modulated by vitamin D endocrine system, were identified in transcriptomic datasets from patient's cells. Further analysis of differentially expressed genes provided eight novel genes with a conserved motif with vitamin D-responsive elements, implying the role of both direct and indirect mechanisms of gene expression by the dysregulated vitamin D endocrine system in SARS-CoV-2-infected cells. Protein-protein interaction network of differentially expressed vitamin D-modulated genes were enriched in the immune system, NF-κB/cytokine signaling, and cell cycle regulation as top predicted pathways that might be affected in the cells of such patients. In brief, the results presented here provide computational evidence to implicate a dysregulated vitamin D endocrine system in the pathobiology of SARS-CoV-2 infection.