CF patients should greatly benefit from 1 or more of the following:
1) Gut-friendly vitamin D (more adsorbable)
2) Topical or buccal Vitamin D (bypass many poor Vitamin D genes)
3) Infrequent Vitamin D dosing (weekly, bi-weekly)
4) Addition of Magnesium (has been found to help CF)
5) Addition of Omega-3 (has been found to help CF)
6) Inhaled Vitamin D (bypass many poor Vitamin D genes)
7) Addition of probiotic or prebiotic (reduce gut inflammation and improve Vit. D absorption)
8) Addition of vitamin D from the sun or UVB (which bypasses poor genes and poor gut)
Vitamin D deficiency in patients with cystic fibrosis: a systematic review and meta-analysis
J Health Popul Nutr . 2024 Jan 17;43(1):11. doi: 10.1186/s41043-024-00499-2
Nazanin Farahbakhsh 1, Somaye Fatahi 2 3, Armin Shirvani 4, Monireh Sadat Motaharifard 5, Masoumeh Mohkam
Aim: Vitamin D is a prominent modulator of immunity and respiratory function. It plays a vital role in respiratory diseases such as cystic fibrosis (CF). S. However, there is a dearth of information on patients with CF. The purpose of the meta-analysis is to highlight the importance of following the existing guidelines regarding maintenance of Vitamin D serum levels in patients with CF.
Methods: The systematic search was conducted without utilizing any time or language limitations in original database from the beginning until March 2022. The meta-analysis was performed using a random-effects model. Heterogeneity was determined by I2 statistics and Cochrane Q test.
Results: Pooled analysis using the random-effects model of the 8 case-control studies with 13 effect sizes revealed that the serum 25-OH-vitamin D in participants with cystic fibrosis was significantly lower than controls in pediatrics and adolescents (WMD: - 3.41 ng/ml, 95% CI - 5.02, - 1.80, p = < 0.001) and adults (WMD: - 2.60 ng/ml, 95% CI - 4.32, - 0.89, p = 0.003). Based on data from 12 studies (21 effect sizes) with a total of 1622 participants, the prevalence of vitamin D levels of 20-30 ng/ml in CF patients was 36% among pediatrics/adolescents and 63% among adults. In addition, 27% of pediatric/adolescent CF patients and 35% of adult CF patients had vitamin D levels of below 20 ng/ml.
Conclusions: As a result, according to the existing guidelines, our results proved the need to pay attention to the level of vitamin D in these patients.
Download the PDF from VitaminDWiki
VitaminDWiki – Cystic Fibrosis category listing contains
- Cystic Fibrosis patients have low vitamin D (need different dosing) – meta-analysis Jan 2024
- Cystic Fibrosis appears associated with poor Vitamin D genes (radioactive tracing) – May 2023
- Poor or no response to vitamin D was associated with poor genes (cystic fibrosis, 4 genes) Sept 2022
- Cystic Fibrosis is safely treated by high-dose Vitamin D – Sept 2019
- Cystic Fibrosis patients need different forms of Vitamin D – Nov 2021
- Cystic Fibrosis probably treated by Vitamin D (if use enough of the right type ) – Oct 2019
- Cystic Fibrosis helped in many ways by Vitamin K – July 2019
- Cystic Fibrosis vitamin D recommendations are not enough - Dec 2021
- Half of Cystic Fibrosis patients have low Magnesium levels – April 2022
- Powder-based Vitamin D may be gut-friendly (Cystic Fibrosis) – RCT Aug 2017
- Inhaled Vitamin D looks like a possibility for CF - VitaminDWiki
VitaminDWiki – Overview Gut and vitamin D contains gut-friendly information
Getting Vitamin D into your body has the following chart
Getting Vitamin D into your body also has the following
If poorly functioning gut
Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into the bloodstream
Fat-soluble Vitamins go thru the slow lymph system
you can make your own sublingual by dissolving Vitamin D in water or use nano form
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into the bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into the bloodstream. Prescription-only?
Bio-Tech might be useful – it is also water-soluble
Vitamin D sprayed inside cheeks (buccal spray) - several studies
and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut
| Bio | Form | Speed | Duration |
| 10 | Injection ($$$) or Calcidiol or Calcitriol | D - Slow C -Fast | Long |
| 10 | Sun/UVB | Slow | Long |
| 10 | Topical (skin patch/cream, vagina) | Slow Fast nano | Normal |
| 9 | Nanoemulsion -mucosal perhaps activates VDR | Fast | Normal |
| 9? | Inhaled (future) | Fast | Normal |
| 8 | Bio-D-Mulsion Forte | Normal | Normal |
| 6 | Water soluble (Bio-Tech) | Normal | Normal |
| 4 | Sublingual/spray (some goes into gut) | Fast | Normal |
| 3 | Coconut oil based | Slow | Normal |
| 2 | Food (salmon etc.) | Slow | Normal |
| 2 | Olive oil based (majority) | Slow | Normal |
10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months
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